Design, synthesis and biological evaluation of 7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as selective Btk inhibitors with improved pharmacokinetic properties for the treatment of rheumatoid arthritis Article Swipe
Linhong He
,
Heying Pei
,
Chufeng Zhang
,
Mingfeng Shao
,
Dan Li
,
Mingli Tang
,
Taijing Wang
,
Xiaoxin Chen
,
Mingli Xiang
,
Lijuan Chen
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1016/j.ejmech.2017.12.079
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1016/j.ejmech.2017.12.079
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.ejmech.2017.12.079
- OA Status
- green
- Cited By
- 20
- References
- 34
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2778678639
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2778678639Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1016/j.ejmech.2017.12.079Digital Object Identifier
- Title
-
Design, synthesis and biological evaluation of 7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as selective Btk inhibitors with improved pharmacokinetic properties for the treatment of rheumatoid arthritisWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-12-28Full publication date if available
- Authors
-
Linhong He, Heying Pei, Chufeng Zhang, Mingfeng Shao, Dan Li, Mingli Tang, Taijing Wang, Xiaoxin Chen, Mingli Xiang, Lijuan ChenList of authors in order
- Landing page
-
https://doi.org/10.1016/j.ejmech.2017.12.079Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
- OA URL
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https://doi.org/10.7270/q2p272trDirect OA link when available
- Concepts
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Bruton's tyrosine kinase, Chemistry, Ibrutinib, Pharmacology, Tyrosine kinase, IC50, Rheumatoid arthritis, Kinase, hERG, Pharmacokinetics, Arthritis, Stereochemistry, In vitro, Biochemistry, Receptor, Medicine, Immunology, Internal medicine, Leukemia, Chronic lymphocytic leukemia, Potassium channelTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
20Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 2, 2023: 3, 2022: 3, 2021: 5Per-year citation counts (last 5 years)
- References (count)
-
34Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index | |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 90 |
| corresponding_author_ids | https://openalex.org/A5100437849 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 10 |
| corresponding_institution_ids | https://openalex.org/I24185976 |
| citation_normalized_percentile.value | 0.75841994 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |