Detection and analysis of circulating large intergenic non‐coding RNA regulator of reprogramming in plasma for breast cancer Article Swipe
Kaijiong Zhang
,
Zhenglian Luo
,
Yi Zhang
,
Yuzhi Wang
,
Meng Cui
,
Lian Liu
,
Li Zhang
,
Jinbo Liu
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1111/1759-7714.12537
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1111/1759-7714.12537
Background Previous studies have indicated that large intergenic non‐coding RNA regulator of reprogramming (lincRNA‐ROR) plays an important role in regulating tumor carcinogenesis and metastasis; however, whether circulating lincRNA‐ROR could function as a potential biomarker for breast cancer (BC) diagnosis and monitoring is unknown. This study was conducted to investigate circulating lincRNA‐ROR in plasma as a potential biomarker for BC diagnosis and monitoring. Methods We performed reverse transcription‐quantitative‐PCR to examine lincRNA‐ROR expression levels in cell lines, 24 pairs of BC tissue samples, and 94 plasma samples from BC patients. Potential correlations between plasma lincRNA‐ROR levels and clinicopathological characteristics were analyzed. A receiver operating characteristic curve was calculated to evaluate the diagnostic values for BC. Pearson correlation analysis of lincRNA‐ROR in plasma samples and the corresponding tissues of the same patients was performed to explore tumor monitoring values. Results LincRNA‐ROR expression was significantly increased in BC cell lines, tissues, and plasma (all P < 0.01). Plasma lincRNA‐ROR levels were associated with estrogen receptors ( P = 0.042) and lymph node metastasis ( P = 0.046). The area under the receiver operating characteristic curve of plasma lincRNA‐ROR was 0.844 (sensitivity 80.0%, specificity 56.7%), which was higher than carcinoembryonic and carbohydrate antigen 15‐3 values. Moreover, plasma lincRNA‐ROR levels were decreased in postoperative compared to preoperative samples ( P < 0.0001). Plasma lincRNA‐ROR levels moderately correlated with the corresponding tissue level in the same patients (r 2 = 0.638, P < 0.0001). Conclusion Plasma lincRNA‐ROR may be a potential biomarker for BC diagnosis and a dynamic monitor.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/1759-7714.12537
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1759-7714.12537
- OA Status
- gold
- Cited By
- 15
- References
- 47
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2765268899
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Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2765268899Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1111/1759-7714.12537Digital Object Identifier
- Title
-
Detection and analysis of circulating large intergenic non‐coding RNA regulator of reprogramming in plasma for breast cancerWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-11-01Full publication date if available
- Authors
-
Kaijiong Zhang, Zhenglian Luo, Yi Zhang, Yuzhi Wang, Meng Cui, Lian Liu, Li Zhang, Jinbo LiuList of authors in order
- Landing page
-
https://doi.org/10.1111/1759-7714.12537Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1759-7714.12537Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1759-7714.12537Direct OA link when available
- Concepts
-
Medicine, Breast cancer, Metastasis, Biomarker, Carcinogenesis, Receiver operating characteristic, Carcinoembryonic antigen, Cancer research, Long non-coding RNA, Internal medicine, RNA, Oncology, Cancer, Molecular biology, Biology, Gene, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
15Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2023: 1, 2022: 1, 2021: 2, 2020: 7Per-year citation counts (last 5 years)
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47Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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