Detection of lentiviral suicide gene therapy in C6 rat glioma using hyperpolarised [1‐13C]pyruvate Article Swipe
Riikka Nivajärvi
,
Venla Olsson
,
Viivi Hyppönen
,
Sean Bowen
,
Hanna Leinonen
,
Hanna P. Lesch
,
Jan Henrik Ardenkjær‐Larsen
,
Olli Gröhn
,
Seppo Ylä‐Herttuala
,
Mikko I. Kettunen
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1002/nbm.4250
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1002/nbm.4250
Hyperpolarised [1‐ 13 C]pyruvate MRI has shown promise in monitoring therapeutic efficacy in a number of cancers including glioma. In this study, we assessed the pyruvate response to the lentiviral suicide gene therapy of herpes simplex virus‐1 thymidine kinase with the prodrug ganciclovir (HSV‐TK/GCV) in C6 rat glioma and compared it with traditional MR therapy markers. Female Wistar rats were inoculated with 10 6 C6 glioma cells. Treated animals received intratumoural lentiviral HSV‐TK gene transfers on days 7 and 8 followed by 2‐week GCV therapy starting on day 10. Animals were repeatedly imaged during therapy using volumetric MRI, diffusion and relaxation mapping, as well as metabolic [1‐ 13 C]pyruvate MRS imaging. Survival (measured as time before animals reached a humane endpoint and were euthanised) was assessed up to day 30 posttherapy. HSV‐TK/GCV gene therapy lengthened the median survival time from 12 to 25 days. This was accompanied by an apparent tumour growth arrest, but no changes in diffusion or relaxation parameters in treated animals. The metabolic response was more evident in the case‐by‐case analysis than in the group‐level analysis. Treated animals also showed a 37 ± 15% decrease ( P < 0.05, n = 5) in lactate‐to‐pyruvate ratio between therapy weeks, whereas a 44 ± 18% increase ( P < 0.05, n = 6) was observed in control animals. Hyperpolarised [1‐ 13 C]pyruvate MRI can offer complementary metabolic information to traditional MR methods to give a more comprehensive picture of the slowly developing gene therapy response. This may benefit the detection of the successful therapy response in patients.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/nbm.4250
- OA Status
- green
- Cited By
- 6
- References
- 41
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3000394952
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3000394952Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/nbm.4250Digital Object Identifier
- Title
-
Detection of lentiviral suicide gene therapy in C6 rat glioma using hyperpolarised [1‐13C]pyruvateWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-01-07Full publication date if available
- Authors
-
Riikka Nivajärvi, Venla Olsson, Viivi Hyppönen, Sean Bowen, Hanna Leinonen, Hanna P. Lesch, Jan Henrik Ardenkjær‐Larsen, Olli Gröhn, Seppo Ylä‐Herttuala, Mikko I. KettunenList of authors in order
- Landing page
-
https://doi.org/10.1002/nbm.4250Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
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https://orbit.dtu.dk/en/publications/2fc8d8d4-046e-4841-a458-1482f7f3e95aDirect OA link when available
- Concepts
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Glioma, Genetic enhancement, Suicide gene, Phosphocreatine, Ganciclovir, Medicine, Internal medicine, Endocrinology, Cancer research, Chemistry, Biology, Gene, Virology, Virus, Energy metabolism, Biochemistry, Human cytomegalovirusTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
6Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2023: 2, 2021: 2Per-year citation counts (last 5 years)
- References (count)
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41Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.MRI, | 97 |
| abstract_inverted_index.This | 144, 246 |
| abstract_inverted_index.also | 181 |
| abstract_inverted_index.days | 76 |
| abstract_inverted_index.from | 139 |
| abstract_inverted_index.gene | 31, 73, 132, 243 |
| abstract_inverted_index.give | 234 |
| abstract_inverted_index.more | 168, 236 |
| abstract_inverted_index.rats | 58 |
| abstract_inverted_index.than | 174 |
| abstract_inverted_index.this | 20 |
| abstract_inverted_index.time | 114, 138 |
| abstract_inverted_index.well | 103 |
| abstract_inverted_index.were | 59, 90, 122 |
| abstract_inverted_index.with | 39, 51, 61 |
| abstract_inverted_index.0.05, | 191, 210 |
| abstract_inverted_index.[1‐ | 1, 106, 220 |
| abstract_inverted_index.days. | 143 |
| abstract_inverted_index.offer | 225 |
| abstract_inverted_index.ratio | 197 |
| abstract_inverted_index.shown | 6 |
| abstract_inverted_index.using | 95 |
| abstract_inverted_index.Female | 56 |
| abstract_inverted_index.Wistar | 57 |
| abstract_inverted_index.before | 115 |
| abstract_inverted_index.cells. | 66 |
| abstract_inverted_index.during | 93 |
| abstract_inverted_index.glioma | 47, 65 |
| abstract_inverted_index.growth | 151 |
| abstract_inverted_index.herpes | 34 |
| abstract_inverted_index.humane | 119 |
| abstract_inverted_index.imaged | 92 |
| abstract_inverted_index.kinase | 38 |
| abstract_inverted_index.median | 136 |
| abstract_inverted_index.number | 14 |
| abstract_inverted_index.showed | 182 |
| abstract_inverted_index.slowly | 241 |
| abstract_inverted_index.study, | 21 |
| abstract_inverted_index.tumour | 150 |
| abstract_inverted_index.weeks, | 200 |
| abstract_inverted_index.Animals | 89 |
| abstract_inverted_index.Treated | 67, 179 |
| abstract_inverted_index.animals | 68, 116, 180 |
| abstract_inverted_index.arrest, | 152 |
| abstract_inverted_index.benefit | 248 |
| abstract_inverted_index.between | 198 |
| abstract_inverted_index.cancers | 16 |
| abstract_inverted_index.changes | 155 |
| abstract_inverted_index.control | 217 |
| abstract_inverted_index.evident | 169 |
| abstract_inverted_index.glioma. | 18 |
| abstract_inverted_index.methods | 232 |
| abstract_inverted_index.picture | 238 |
| abstract_inverted_index.prodrug | 41 |
| abstract_inverted_index.promise | 7 |
| abstract_inverted_index.reached | 117 |
| abstract_inverted_index.simplex | 35 |
| abstract_inverted_index.suicide | 30 |
| abstract_inverted_index.therapy | 32, 54, 84, 94, 133, 199, 244, 254 |
| abstract_inverted_index.treated | 162 |
| abstract_inverted_index.whereas | 201 |
| abstract_inverted_index.2‐week | 82 |
| abstract_inverted_index.HSV‐TK | 72 |
| abstract_inverted_index.Survival | 111 |
| abstract_inverted_index.analysis | 173 |
| abstract_inverted_index.animals. | 163, 218 |
| abstract_inverted_index.apparent | 149 |
| abstract_inverted_index.assessed | 23, 125 |
| abstract_inverted_index.compared | 49 |
| abstract_inverted_index.decrease | 187 |
| abstract_inverted_index.efficacy | 11 |
| abstract_inverted_index.endpoint | 120 |
| abstract_inverted_index.followed | 80 |
| abstract_inverted_index.imaging. | 110 |
| abstract_inverted_index.increase | 206 |
| abstract_inverted_index.mapping, | 101 |
| abstract_inverted_index.markers. | 55 |
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| abstract_inverted_index.pyruvate | 25 |
| abstract_inverted_index.received | 69 |
| abstract_inverted_index.response | 26, 166, 255 |
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| abstract_inverted_index.survival | 137 |
| abstract_inverted_index.(measured | 112 |
| abstract_inverted_index.analysis. | 178 |
| abstract_inverted_index.detection | 250 |
| abstract_inverted_index.diffusion | 98, 157 |
| abstract_inverted_index.including | 17 |
| abstract_inverted_index.metabolic | 105, 165, 227 |
| abstract_inverted_index.patients. | 257 |
| abstract_inverted_index.response. | 245 |
| abstract_inverted_index.thymidine | 37 |
| abstract_inverted_index.transfers | 74 |
| abstract_inverted_index.virus‐1 | 36 |
| abstract_inverted_index.C]pyruvate | 3, 108, 222 |
| abstract_inverted_index.developing | 242 |
| abstract_inverted_index.inoculated | 60 |
| abstract_inverted_index.lengthened | 134 |
| abstract_inverted_index.lentiviral | 29, 71 |
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| abstract_inverted_index.parameters | 160 |
| abstract_inverted_index.relaxation | 100, 159 |
| abstract_inverted_index.repeatedly | 91 |
| abstract_inverted_index.successful | 253 |
| abstract_inverted_index.volumetric | 96 |
| abstract_inverted_index.accompanied | 146 |
| abstract_inverted_index.euthanised) | 123 |
| abstract_inverted_index.ganciclovir | 42 |
| abstract_inverted_index.information | 228 |
| abstract_inverted_index.therapeutic | 10 |
| abstract_inverted_index.traditional | 52, 230 |
| abstract_inverted_index.HSV‐TK/GCV | 131 |
| abstract_inverted_index.posttherapy. | 130 |
| abstract_inverted_index.complementary | 226 |
| abstract_inverted_index.comprehensive | 237 |
| abstract_inverted_index.group‐level | 177 |
| abstract_inverted_index.intratumoural | 70 |
| abstract_inverted_index.(HSV‐TK/GCV) | 43 |
| abstract_inverted_index.Hyperpolarised | 0, 219 |
| abstract_inverted_index.case‐by‐case | 172 |
| abstract_inverted_index.lactate‐to‐pyruvate | 196 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 93 |
| corresponding_author_ids | https://openalex.org/A5067646436 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 10 |
| corresponding_institution_ids | https://openalex.org/I175532246 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8600000143051147 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.57356653 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |