Determinants of Innate Immunity in Visceral Leishmaniasis and Their Implication in Vaccine Development Article Swipe
Greta Volpedo
,
Thalia Pacheco‐Fernández
,
Parna Bhattacharya
,
Timur Oljuskin
,
Ranadhir Dey
,
Sreenivas Gannavaram
,
Abhay R. Satoskar
,
Hira L. Nakhasi
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2021.748325
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2021.748325
Leishmaniasis is endemic to the tropical and subtropical regions of the world and is transmitted by the bite of an infected sand fly. The multifaceted interactions between Leishmania , the host innate immune cells, and the adaptive immunity determine the severity of pathogenesis and disease development. Leishmania parasites establish a chronic infection by subversion and attenuation of the microbicidal functions of phagocytic innate immune cells such as neutrophils, macrophages and dendritic cells (DCs). Other innate cells such as inflammatory monocytes, mast cells and NK cells, also contribute to resistance and/or susceptibility to Leishmania infection. In addition to the cytokine/chemokine signals from the innate immune cells, recent studies identified the subtle shifts in the metabolic pathways of the innate cells that activate distinct immune signal cascades. The nexus between metabolic pathways, epigenetic reprogramming and the immune signaling cascades that drive the divergent innate immune responses, remains to be fully understood in Leishmania pathogenesis. Further, development of safe and efficacious vaccines against Leishmaniasis requires a broader understanding of the early interactions between the parasites and innate immune cells. In this review we focus on the current understanding of the specific role of innate immune cells, the metabolomic and epigenetic reprogramming and immune regulation that occurs during visceral leishmaniasis, and the strategies used by the parasite to evade and modulate host immunity. We highlight how such pathways could be exploited in the development of safe and efficacious Leishmania vaccines.
Related Topics
Concepts
Innate immune system
Biology
Immune system
Immunology
Acquired immune system
Leishmania
Innate lymphoid cell
Immunity
CCL18
Classical complement pathway
Complement system
Parasite hosting
Computer science
World Wide Web
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fimmu.2021.748325
- https://www.frontiersin.org/articles/10.3389/fimmu.2021.748325/pdf
- OA Status
- gold
- Cited By
- 47
- References
- 214
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3205949716
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3205949716Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fimmu.2021.748325Digital Object Identifier
- Title
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Determinants of Innate Immunity in Visceral Leishmaniasis and Their Implication in Vaccine DevelopmentWork title
- Type
-
reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-10-12Full publication date if available
- Authors
-
Greta Volpedo, Thalia Pacheco‐Fernández, Parna Bhattacharya, Timur Oljuskin, Ranadhir Dey, Sreenivas Gannavaram, Abhay R. Satoskar, Hira L. NakhasiList of authors in order
- Landing page
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https://doi.org/10.3389/fimmu.2021.748325Publisher landing page
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https://www.frontiersin.org/articles/10.3389/fimmu.2021.748325/pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.frontiersin.org/articles/10.3389/fimmu.2021.748325/pdfDirect OA link when available
- Concepts
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Innate immune system, Biology, Immune system, Immunology, Acquired immune system, Leishmania, Innate lymphoid cell, Immunity, CCL18, Classical complement pathway, Complement system, Parasite hosting, Computer science, World Wide WebTop concepts (fields/topics) attached by OpenAlex
- Cited by
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47Total citation count in OpenAlex
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2025: 4, 2024: 17, 2023: 16, 2022: 10Per-year citation counts (last 5 years)
- References (count)
-
214Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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