Determination of serum visfatin levels in patients with Behçet’s disease: A case–control study Article Swipe
Saeedeh Shenavandeh
,
Maryam Barkhordar
,
Eskandar Kamali Sarvestani
,
Elham Aflaki
,
Zahra Habib Agahi
,
Mohammad Ali Nazarinia
·
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1016/j.ejr.2014.12.004
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1016/j.ejr.2014.12.004
Behçet's disease (BD) is an inflammatory, systemic and chronic disorder with unknown etiology affecting multiple systems. Visfatin is a new adipokine with insulin-mimetic properties and pro-inflammatory function. The serum visfatin levels were evaluated in BD patients to investigate its role in the pathogenesis and clinical manifestations of the disease. Forty BD patients were recruited from the Behçet's disease clinic at Shiraz University of Medical Sciences in southern Iran and 40 healthy control subjects of matching age, sex and body mass index (BMI) were also included. Serum visfatin level was measured using ELISA. The 40 BD patients included 16 males and 24 females. Seventeen had active clinical manifestations; 16 with oral ulcer, 5 with genital ulcer, 6 with arthritis and 2 with uveitis. The mean age of the BD patients was 34.95 ± 9.6 years and mean BMI was 23.98 ± 4.44. There were no significant differences between cases (5.05 ± 3.05 ng/ml) and controls (4.72 ± 2.84 ng/ml) in the visfatin level (p = 0.61). The difference in the visfatin level between patients with active and inactive manifestations did not reach statistical significance (6.13 ± 3.20 and 4.25 ± 2.73, respectively; p = 0.07). There was no significant difference according to the gender of the patients or the presence of clinical manifestations. In view of the results in this study, visfatin levels were not significantly different between cases and controls. There was a tendency to a higher level of serum visfatin in active BD patients compared to the inactive cases; however, the difference was unremarkable.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.ejr.2014.12.004
- OA Status
- hybrid
- Cited By
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All OpenAlex metadata
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https://openalex.org/W2095238980Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.ejr.2014.12.004Digital Object Identifier
- Title
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Determination of serum visfatin levels in patients with Behçet’s disease: A case–control studyWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2015Year of publication
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2015-01-28Full publication date if available
- Authors
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Saeedeh Shenavandeh, Maryam Barkhordar, Eskandar Kamali Sarvestani, Elham Aflaki, Zahra Habib Agahi, Mohammad Ali NazariniaList of authors in order
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https://doi.org/10.1016/j.ejr.2014.12.004Publisher landing page
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://doi.org/10.1016/j.ejr.2014.12.004Direct OA link when available
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Medicine, Behcet's disease, Internal medicine, Gastroenterology, Body mass index, Adipokine, Pathogenesis, Etiology, Disease, Obesity, Insulin resistanceTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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| referenced_works | https://openalex.org/W4232882352, https://openalex.org/W4245289916, https://openalex.org/W1999430191, https://openalex.org/W2171307046, https://openalex.org/W2086373018, https://openalex.org/W6666143004, https://openalex.org/W4235673640, https://openalex.org/W1981473060, https://openalex.org/W2004788968, https://openalex.org/W1975912094, https://openalex.org/W2007538786, https://openalex.org/W2135110328, https://openalex.org/W2090944659, https://openalex.org/W1990495347, https://openalex.org/W2081638903, https://openalex.org/W1932093217, https://openalex.org/W2089872313, https://openalex.org/W1996578984, https://openalex.org/W2004553653, https://openalex.org/W2161392632, https://openalex.org/W4239955861, https://openalex.org/W2122482916, https://openalex.org/W2020618531, https://openalex.org/W2004498697, https://openalex.org/W1470770354, https://openalex.org/W2093215839, https://openalex.org/W2142448194, https://openalex.org/W1987569093, https://openalex.org/W2124808478, https://openalex.org/W2041092685, https://openalex.org/W4300492363, https://openalex.org/W1998347088, https://openalex.org/W2063228908, https://openalex.org/W2021997580, https://openalex.org/W2473433727, https://openalex.org/W2162971189, https://openalex.org/W2027321418, https://openalex.org/W2152319071 |
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