Deuterium-Reinforced Polyunsaturated Fatty Acids Prevent Diet-Induced Nonalcoholic Steatohepatitis by Reducing Oxidative Stress Article Swipe
Haoran Li
,
Ouyang Zhang
,
Chenmin Hui
,
Yaxin Huang
,
Hengrong Shao
,
Menghui Song
,
Lingjia Gao
,
Shengnan Jin
,
Chunming Ding
,
Liang Xu
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/medicina58060790
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/medicina58060790
Background and Objectives: Oxidative stress is implicated in the progression of nonalcoholic steatohepatitis (NASH) through the triggering of inflammation. Deuterium-reinforced polyunsaturated fatty acids (D-PUFAs) are more resistant to the reactive oxygen species (ROS)−initiated chain reaction of lipid peroxidation than regular hydrogenated (H−) PUFAs. Here, we aimed to investigate the impacts of D-PUFAs on oxidative stress and its protective effect on NASH. Materials and Methods: C57BL/6 mice were randomly divided into three groups and were fed a normal chow diet, a methionine–choline-deficient (MCD) diet, and an MCD with 0.6% D-PUFAs for 5 weeks. The phenotypes of NASH in mice were determined. The levels of oxidative stress were examined both in vivo and in vitro. Results: The treatment with D-PUFAs attenuated the ROS production and enhanced the cell viability in tert-butyl hydroperoxide (TBHP)−loaded hepatocytes. Concurrently, D-PUFAs decreased the TBHP-induced oxidative stress in Raw 264.7 macrophages. Accordingly, D-PUFAs increased the cell viability and attenuated the lipopolysaccharide-stimulated proinflammatory cytokine expression of macrophages. In vivo, the administration of D-PUFAs reduced the phenotypes of NASH in MCD-fed mice. Specifically, D-PUFAs decreased the liver transaminase activity and attenuated the steatosis, inflammation, and fibrosis in the livers of NASH mice. Conclusion: D-PUFAs may be potential therapeutic agents to prevent NASH by broadly reducing oxidative stress.
Related Topics
Concepts
Oxidative stress
Polyunsaturated fatty acid
Nonalcoholic steatohepatitis
Chemistry
Oxidative phosphorylation
Steatohepatitis
Biochemistry
Nonalcoholic fatty liver disease
Food science
Medicine
Fatty acid
Internal medicine
Fatty liver
Disease
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/medicina58060790
- https://www.mdpi.com/1648-9144/58/6/790/pdf?version=1655022362
- OA Status
- gold
- Cited By
- 3
- References
- 48
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4282594734
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4282594734Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/medicina58060790Digital Object Identifier
- Title
-
Deuterium-Reinforced Polyunsaturated Fatty Acids Prevent Diet-Induced Nonalcoholic Steatohepatitis by Reducing Oxidative StressWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-06-12Full publication date if available
- Authors
-
Haoran Li, Ouyang Zhang, Chenmin Hui, Yaxin Huang, Hengrong Shao, Menghui Song, Lingjia Gao, Shengnan Jin, Chunming Ding, Liang XuList of authors in order
- Landing page
-
https://doi.org/10.3390/medicina58060790Publisher landing page
- PDF URL
-
https://www.mdpi.com/1648-9144/58/6/790/pdf?version=1655022362Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1648-9144/58/6/790/pdf?version=1655022362Direct OA link when available
- Concepts
-
Oxidative stress, Polyunsaturated fatty acid, Nonalcoholic steatohepatitis, Chemistry, Oxidative phosphorylation, Steatohepatitis, Biochemistry, Nonalcoholic fatty liver disease, Food science, Medicine, Fatty acid, Internal medicine, Fatty liver, DiseaseTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 1Per-year citation counts (last 5 years)
- References (count)
-
48Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.acids | 22 |
| abstract_inverted_index.aimed | 45 |
| abstract_inverted_index.chain | 33 |
| abstract_inverted_index.diet, | 78, 82 |
| abstract_inverted_index.fatty | 21 |
| abstract_inverted_index.lipid | 36 |
| abstract_inverted_index.liver | 176 |
| abstract_inverted_index.mice. | 171, 191 |
| abstract_inverted_index.three | 70 |
| abstract_inverted_index.vivo, | 159 |
| abstract_inverted_index.(H−) | 41 |
| abstract_inverted_index.(NASH) | 13 |
| abstract_inverted_index.PUFAs. | 42 |
| abstract_inverted_index.agents | 198 |
| abstract_inverted_index.effect | 58 |
| abstract_inverted_index.groups | 71 |
| abstract_inverted_index.levels | 101 |
| abstract_inverted_index.livers | 188 |
| abstract_inverted_index.normal | 76 |
| abstract_inverted_index.oxygen | 30 |
| abstract_inverted_index.stress | 4, 54, 104, 138 |
| abstract_inverted_index.vitro. | 112 |
| abstract_inverted_index.weeks. | 91 |
| abstract_inverted_index.C57BL/6 | 64 |
| abstract_inverted_index.D-PUFAs | 51, 88, 117, 133, 144, 163, 173, 193 |
| abstract_inverted_index.MCD-fed | 170 |
| abstract_inverted_index.broadly | 203 |
| abstract_inverted_index.divided | 68 |
| abstract_inverted_index.impacts | 49 |
| abstract_inverted_index.prevent | 200 |
| abstract_inverted_index.reduced | 164 |
| abstract_inverted_index.regular | 39 |
| abstract_inverted_index.species | 31 |
| abstract_inverted_index.stress. | 206 |
| abstract_inverted_index.through | 14 |
| abstract_inverted_index.Methods: | 63 |
| abstract_inverted_index.Results: | 113 |
| abstract_inverted_index.activity | 178 |
| abstract_inverted_index.cytokine | 154 |
| abstract_inverted_index.enhanced | 123 |
| abstract_inverted_index.examined | 106 |
| abstract_inverted_index.fibrosis | 185 |
| abstract_inverted_index.randomly | 67 |
| abstract_inverted_index.reaction | 34 |
| abstract_inverted_index.reactive | 29 |
| abstract_inverted_index.reducing | 204 |
| abstract_inverted_index.(D-PUFAs) | 23 |
| abstract_inverted_index.Materials | 61 |
| abstract_inverted_index.Oxidative | 3 |
| abstract_inverted_index.decreased | 134, 174 |
| abstract_inverted_index.increased | 145 |
| abstract_inverted_index.oxidative | 53, 103, 137, 205 |
| abstract_inverted_index.potential | 196 |
| abstract_inverted_index.resistant | 26 |
| abstract_inverted_index.treatment | 115 |
| abstract_inverted_index.viability | 126, 148 |
| abstract_inverted_index.Background | 0 |
| abstract_inverted_index.attenuated | 118, 150, 180 |
| abstract_inverted_index.expression | 155 |
| abstract_inverted_index.implicated | 6 |
| abstract_inverted_index.phenotypes | 93, 166 |
| abstract_inverted_index.production | 121 |
| abstract_inverted_index.protective | 57 |
| abstract_inverted_index.steatosis, | 182 |
| abstract_inverted_index.tert-butyl | 128 |
| abstract_inverted_index.triggering | 16 |
| abstract_inverted_index.Conclusion: | 192 |
| abstract_inverted_index.Objectives: | 2 |
| abstract_inverted_index.determined. | 99 |
| abstract_inverted_index.investigate | 47 |
| abstract_inverted_index.progression | 9 |
| abstract_inverted_index.therapeutic | 197 |
| abstract_inverted_index.Accordingly, | 143 |
| abstract_inverted_index.TBHP-induced | 136 |
| abstract_inverted_index.hepatocytes. | 131 |
| abstract_inverted_index.hydrogenated | 40 |
| abstract_inverted_index.macrophages. | 142, 157 |
| abstract_inverted_index.nonalcoholic | 11 |
| abstract_inverted_index.peroxidation | 37 |
| abstract_inverted_index.transaminase | 177 |
| abstract_inverted_index.Concurrently, | 132 |
| abstract_inverted_index.Specifically, | 172 |
| abstract_inverted_index.hydroperoxide | 129 |
| abstract_inverted_index.inflammation, | 183 |
| abstract_inverted_index.inflammation. | 18 |
| abstract_inverted_index.administration | 161 |
| abstract_inverted_index.(TBHP)−loaded | 130 |
| abstract_inverted_index.polyunsaturated | 20 |
| abstract_inverted_index.proinflammatory | 153 |
| abstract_inverted_index.steatohepatitis | 12 |
| abstract_inverted_index.(ROS)−initiated | 32 |
| abstract_inverted_index.Deuterium-reinforced | 19 |
| abstract_inverted_index.lipopolysaccharide-stimulated | 152 |
| abstract_inverted_index.methionine–choline-deficient | 80 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 90 |
| corresponding_author_ids | https://openalex.org/A5022450169, https://openalex.org/A5067449384, https://openalex.org/A5072737130 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 10 |
| corresponding_institution_ids | https://openalex.org/I27781120 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/6 |
| sustainable_development_goals[0].score | 0.4099999964237213 |
| sustainable_development_goals[0].display_name | Clean water and sanitation |
| citation_normalized_percentile.value | 0.64320919 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |