Deutsch‐Österreichische S2k‐Leitlinie: Anale Dysplasien und Analkarzinom‐Screening bei Menschen mit HIV Article Swipe
David Chromy
,
Felix Aigner
,
Jürgen C. Becker
,
Markus Bickel
,
Andrea Brunner
,
Johannes Claßen
,
Monika Hampl
,
Doris Helbig
,
Marcus Hentrich
,
Franc Hetzer
,
Christian Pieter Hoffmann
,
Johannes Jongen
,
Elmar A. Joura
,
Reinhard Kirnbauer
,
Alexander Kreuter
,
Gerold Felician Lang
,
Memo Mokhles
,
Frank Oellig
,
Mark Oette
,
Anja Potthoff
,
Andreas D. Rink
,
Andreas Salat
,
Axel J. Schmidt
,
Robert Siegel
,
Georg Stary
,
Ricardo Niklas Werner
,
Gerhard Weyandt
,
Ulrike Wieland
,
Stefan Eßer
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1111/ddg.15719_g
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1111/ddg.15719_g
Zusammenfassung Menschen mit HIV sind im Vergleich zur Allgemeinbevölkerung bis zu 100‐mal häufiger von Analkarzinomen betroffen. Werden Vorläufer, das bedeutet hochgradige anale Dysplasien, diagnostiziert und therapiert, kann das Risiko für das Auftreten eines Analkarzinoms statistisch signifikant reduziert werden. Faktoren für eine höhere Wahrscheinlichkeit für Analkarzinome und deren Vorläufer sind beispielsweise zunehmendes Alter, ein niedriger CD4 + T‐Lymphozyten Nadir, aktives Zigarettenrauchen, rezeptiver Analverkehr oder persistierender Nachweis von Hoch‐Risiko (HR)‐Typen des humanen Papillomavirus (HPV). Eine Screening‐Empfehlung besteht vorwiegend für alle Männer, die Sex mit Männern haben und Transgender‐Frauen mit HIV ab dem 35. Lebensjahr sowie für alle Menschen mit HIV ab dem 45. Lebensjahr. Nach Inspektion und digital rektaler Untersuchung wird eine anale Zytologie angefertigt. Ein HR‐HPV‐Nachweis kann ergänzend erfolgen. Bei klinischen Auffälligkeiten sowie ab „ASC‐US“ ist die Zuweisung zur hochauflösenden Anoskopie indiziert. Stellen sich hierbei Läsionen dar, ist eine histopathologische Diagnosesicherung anzustreben. Bei analen intraepithelialen Neoplasien (AIN) Grad III und AIN II mit p16‐Positivität entspricht der Befund einer hochgradigen Dysplasie und erfordert eine Therapie. Die stärksten Therapieempfehlungen bestehen für die Elektrokaustik, die Anwendung von 85%iger Trichloressigsäure sowie die operative Abtragung. Abschließend wird in dieser Leitlinie darauf eingegangen, wie das Analkarzinom‐Screening auf Menschen ohne HIV übertragen werden kann.
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- Type
- article
- Language
- de
- Landing Page
- https://doi.org/10.1111/ddg.15719_g
- OA Status
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- References
- 94
- Related Works
- 10
- OpenAlex ID
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https://openalex.org/W4413213649Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1111/ddg.15719_gDigital Object Identifier
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Deutsch‐Österreichische S2k‐Leitlinie: Anale Dysplasien und Analkarzinom‐Screening bei Menschen mit HIVWork title
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articleOpenAlex work type
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dePrimary language
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2025Year of publication
- Publication date
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2025-08-01Full publication date if available
- Authors
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David Chromy, Felix Aigner, Jürgen C. Becker, Markus Bickel, Andrea Brunner, Johannes Claßen, Monika Hampl, Doris Helbig, Marcus Hentrich, Franc Hetzer, Christian Pieter Hoffmann, Johannes Jongen, Elmar A. Joura, Reinhard Kirnbauer, Alexander Kreuter, Gerold Felician Lang, Memo Mokhles, Frank Oellig, Mark Oette, Anja Potthoff, Andreas D. Rink, Andreas Salat, Axel J. Schmidt, Robert Siegel, Georg Stary, Ricardo Niklas Werner, Gerhard Weyandt, Ulrike Wieland, Stefan EßerList of authors in order
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://www.ncbi.nlm.nih.gov/pmc/articles/12338394Direct OA link when available
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Gynecology, MedicineTop concepts (fields/topics) attached by OpenAlex
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10Other works algorithmically related by OpenAlex
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