DEveloping BBB-ASL as non-Invasive Early biomarker of Alzheimer's Disease (DEBBIE-AD): Study design Article Swipe
Beatriz Padrela
,
Amnah Mahroo
,
Mervin Tee
,
Markus H. Sneve
,
Paulien Moyaert
,
Oliver Geier
,
Joost P.A. Kuijer
,
Soetkin Beun
,
Wibeke Nordhøy
,
Yufei David Zhu
,
Mareike Alicja Buck
,
Daniel Hoinkiss
,
Simon Konstandin
,
Jörn Huber
,
Julia Wiersinga
,
Roos M. Rikken
,
Diederick de Leeuw
,
Håkon Grydeland
,
Lynette J. Tippett
,
Erin E. Cawston
,
Esin Öztürk-Işık
,
Jennifer Linn
,
Moritz Brandt
,
Betty M. Tijms
,
Elsmarieke van de Giessen
,
Majon Muller
,
Anders M. Fjell
,
Kristine B. Walhovd
,
Lene Pålhaugen
,
Per Selnes
,
Patricia Clement
,
Eric Achten
,
Udunna Anazodo
,
Frederik Barkhof
,
Saima Hilal
,
Tormod Fladby
,
Klaus Eickel
,
Catherine Morgan
,
David Thomas
,
Jan Petr
,
Matthias Günther
,
Henk Mutsaerts
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.cccb.2024.100308
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.cccb.2024.100308
Introduction: Arterial spin labeling (ASL) MRI, a non-invasive technique for imaging perfusion, now allows studying BBB permeability. The DEveloping BBB-ASL as a non-Invasive Early biomarker of Alzheimer's Disease (DEBBIE-AD) multi-cohort study integrates this modified BBB-ASL technique in several healthy and diseased populations (Table 1) to study methodological and clinical research questions (Table 2) on the ability of BBB-ASL as an early AD biomarker. Methods: DEBBIE-AD will enroll various cohorts with subjective cognitive decline, mild cognitive impairment, and AD dementia, as well as age-matched healthy controls, at seven sites (Table 1). Our newly developed BBB-ASL sequence — implemented with the vendor-independent MRI framework gammaSTAR — will be added to multiple MRI protocols. The BBB-ASL sequence combines time-encoded multi-post labeling delay pseudo-continuous ASL with a multi-echo 3D GRASE readout, allowing estimating CBF, ATT, and the BBB time of exchange (Tex). Data analyses will be conducted using ExploreASL. Beyond MRI standard sequences, including T1w, T2w, FLAIR, DWI, the DEBBIE clinical outcomes include amyloid-PET and blood and CSF fluid biomarkers (Table 1). Expected Results: Preliminary testing of the BBB-ASL has been conducted on 3T systems (different Siemens Heathineers scanners) in different cohorts at multiple sites. Data processing with ExploreASL includes FSL-FABBER4 for quantification, allowing harmonized image processing. An example of the mean and standard deviation Tex maps of two DEBBIE cohorts is shown in Figure 1 to illustrate the similarities of the Tex patterns from two cohorts of similar-aged healthy adults from different sites. Discussion: The DEBBIE-AD study aims to provide evidence on the ability of BBB-ASL to measure BBB permeability and demonstrate its utility in AD-related pathologies. The presented sequence may provide novel and unique insights into the staging of BBB permeability changes in groups at greater risk of developing AD, which may, in turn, provide new targets for treatment.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.cccb.2024.100308
- OA Status
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- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4402131675
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4402131675Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.cccb.2024.100308Digital Object Identifier
- Title
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DEveloping BBB-ASL as non-Invasive Early biomarker of Alzheimer's Disease (DEBBIE-AD): Study designWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-01-01Full publication date if available
- Authors
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Beatriz Padrela, Amnah Mahroo, Mervin Tee, Markus H. Sneve, Paulien Moyaert, Oliver Geier, Joost P.A. Kuijer, Soetkin Beun, Wibeke Nordhøy, Yufei David Zhu, Mareike Alicja Buck, Daniel Hoinkiss, Simon Konstandin, Jörn Huber, Julia Wiersinga, Roos M. Rikken, Diederick de Leeuw, Håkon Grydeland, Lynette J. Tippett, Erin E. Cawston, Esin Öztürk-Işık, Jennifer Linn, Moritz Brandt, Betty M. Tijms, Elsmarieke van de Giessen, Majon Muller, Anders M. Fjell, Kristine B. Walhovd, Lene Pålhaugen, Per Selnes, Patricia Clement, Eric Achten, Udunna Anazodo, Frederik Barkhof, Saima Hilal, Tormod Fladby, Klaus Eickel, Catherine Morgan, David Thomas, Jan Petr, Matthias Günther, Henk MutsaertsList of authors in order
- Landing page
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https://doi.org/10.1016/j.cccb.2024.100308Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1016/j.cccb.2024.100308Direct OA link when available
- Concepts
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Biomarker, Medicine, Disease, Alzheimer's disease, Neuroscience, Internal medicine, Psychology, Biology, BiochemistryTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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