Development and characterization of a fully humanized ACE2 mouse model Article Swipe
Chunyu Ge
,
Amr R. Salem
,
Amany Elsharkawy
,
Janhavi P. Natekar
,
Anchala Guglani
,
Jaser Doja
,
Osarume Ogala
,
Gavin Wang
,
Susan H. Griffin
,
Orazio J. Slivano
,
Robin Shoemaker
,
Benard O. Ogola
,
Christopher F. Basler
,
Ajay Kumar
,
William B. Bryant
,
Mukesh Kumar
,
Joseph M. Miano
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1186/s12915-025-02293-w
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1186/s12915-025-02293-w
The hACE2 model offers a more accurate approach to studying mechanisms underlying tissue-restricted expression of ACE2, elucidating noncoding sequence variants and an upstream LncRNA, and defining pathways relevant to human disease and associated co-morbidities.
Related Topics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1186/s12915-025-02293-w
- https://bmcbiol.biomedcentral.com/counter/pdf/10.1186/s12915-025-02293-w
- OA Status
- gold
- Cited By
- 3
- References
- 67
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4411874541
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4411874541Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1186/s12915-025-02293-wDigital Object Identifier
- Title
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Development and characterization of a fully humanized ACE2 mouse modelWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
-
2025-07-01Full publication date if available
- Authors
-
Chunyu Ge, Amr R. Salem, Amany Elsharkawy, Janhavi P. Natekar, Anchala Guglani, Jaser Doja, Osarume Ogala, Gavin Wang, Susan H. Griffin, Orazio J. Slivano, Robin Shoemaker, Benard O. Ogola, Christopher F. Basler, Ajay Kumar, William B. Bryant, Mukesh Kumar, Joseph M. MianoList of authors in order
- Landing page
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https://doi.org/10.1186/s12915-025-02293-wPublisher landing page
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https://bmcbiol.biomedcentral.com/counter/pdf/10.1186/s12915-025-02293-wDirect link to full text PDF
- Open access
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YesWhether a free full text is available
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-
goldOpen access status per OpenAlex
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https://bmcbiol.biomedcentral.com/counter/pdf/10.1186/s12915-025-02293-wDirect OA link when available
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Biology, Humanized mouse, Computational biology, Cell biology, Genetics, In vivoTop concepts (fields/topics) attached by OpenAlex
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3Total citation count in OpenAlex
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2025: 3Per-year citation counts (last 5 years)
- References (count)
-
67Number of works referenced by this work
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-
10Other works algorithmically related by OpenAlex
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