Development and properties of duplex MgF2/PCL coatings on biodegradable magnesium alloy for biomedical applications Article Swipe
Preeti Makkar
,
Hoe Jin Kang
,
Andrew Padalhin
,
Ihho Park
,
Byoung-Gi Moon
,
Byong‐Taek Lee
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0193927
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0193927
The present work addresses the performance of polycaprolactone (PCL) coating on fluoride treated (MgF2) biodegradable ZK60 magnesium alloy (Mg) for biomedical application. MgF2 conversion layer was first produced by immersing Mg alloy substrate in hydrofluoric acid solution. The outer PCL coating was then prepared using dip coating technique. Morphology, elements profile, phase structure, roughness, mechanical properties, invitro corrosion, and biocompatibility of duplex MgF2/PCL coating were then characterized and compared to those of fluoride coated and uncoated Mg samples. The invivo degradation behavior and biocompatibility of duplex MgF2/PCL coating with respect to ZK60 Mg alloy were also studied using rabbit model for 2 weeks. SEM and TEM analysis showed that the duplex coating was uniform and comprised of porous PCL film (~3.3 μm) as upper layer with compact MgF2 (~2.2 μm) as inner layer. No significant change in microhardness was found on duplex coating compared with uncoated ZK60 Mg alloy. The duplex coating showed improved invitro corrosion resistance than single layered MgF2 or uncoated alloy samples. The duplex coating also resulted in better cell viability, cell adhesion, and cell proliferation compared to fluoride coated or uncoated alloy. Preliminary invivo studies indicated that duplex MgF2/PCL coating reduced the degradation rate of ZK60 Mg alloy and exhibited good biocompatibility. These results suggested that duplex MgF2/PCL coating on magnesium alloy might have great potential for orthopedic applications.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1371/journal.pone.0193927
- https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0193927&type=printable
- OA Status
- gold
- Cited By
- 35
- References
- 43
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2795578353
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2795578353Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1371/journal.pone.0193927Digital Object Identifier
- Title
-
Development and properties of duplex MgF2/PCL coatings on biodegradable magnesium alloy for biomedical applicationsWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2018Year of publication
- Publication date
-
2018-04-02Full publication date if available
- Authors
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Preeti Makkar, Hoe Jin Kang, Andrew Padalhin, Ihho Park, Byoung-Gi Moon, Byong‐Taek LeeList of authors in order
- Landing page
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https://doi.org/10.1371/journal.pone.0193927Publisher landing page
- PDF URL
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0193927&type=printableDirect link to full text PDF
- Open access
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YesWhether a free full text is available
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-
goldOpen access status per OpenAlex
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0193927&type=printableDirect OA link when available
- Concepts
-
Biocompatibility, Coating, Materials science, Magnesium alloy, Corrosion, Alloy, Magnesium, Composite material, Chemical engineering, Metallurgy, EngineeringTop concepts (fields/topics) attached by OpenAlex
- Cited by
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35Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2024: 6, 2023: 3, 2022: 7, 2021: 7Per-year citation counts (last 5 years)
- References (count)
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43Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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