Development and validation of a diagnostic prediction model reminiscent of systemic inflammation and organ interaction in heart failure preserved ejection fraction (HFpEF) patients Article Swipe
Rong Zhou
,
Yiyuan Xia
,
Zheng Li
,
Li‐Da Wu
,
Yi Shi
,
Zhiyu Ling
,
Junxia Zhang
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-2183043/v1
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-2183043/v1
Purpose Systemic inflammation and reciprocal organ interactions are associated with the pathophysiology of heart failure with preserved ejection fraction (HFpEF). Herein, we proposed a simple diagnostic model with markers from complete routine blood test as well as liver and renal dysfunction for HFpEF. Patients and methods: This is a hospital-based single-center, cross-sectional observation study. 1808 eligible patients with documented cardiovascular diseases were enrolled. HFpEF was diagnosed independently by two expert cardiologists according to the clinical manifestation, echocardiography and the N-Terminal pro B-type natriuretic peptide. A diagnostic model for HFpEF was developed by logistic regression and assessed by ROC and Brier score. Then, the model was validated by the 10-fold cross-validation and presented as nomogram and a web-based online risk calculator as well. Results Patients with HFpEF account for 47.23% in development data. Univariate, multivariate and LASSO regression analysis revealed that age, Hb, NLR, AST/ALT ratio, Cr, UA, atrial fibrillation, and pulmonary arterial hypertension were associated with HFpEF. The predictive model exhibited reasonably accurate discrimination (ROC, 0.753, 95% CI, 0.732 to 0.772) and calibration (Brier score was 0.200). Subsequent internal validation showed good discrimination and calibration (AUC = 0.750, Brier score was 0.202). Conclusion Our new diagnostic model incorporating markers of inflammation, liver-heart and kidney-heart interactions has the predictive ability for HFpEF, and may be helpful for timely diagnosis of patients with HFpEF.
Related Topics
Concepts
Medicine
Internal medicine
Heart failure with preserved ejection fraction
Cardiology
Heart failure
Atrial fibrillation
Brier score
Logistic regression
Ejection fraction
Artificial intelligence
Computer science
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-2183043/v1
- https://www.researchsquare.com/article/rs-2183043/latest.pdf
- OA Status
- green
- Cited By
- 1
- References
- 54
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4307185046
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4307185046Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.21203/rs.3.rs-2183043/v1Digital Object Identifier
- Title
-
Development and validation of a diagnostic prediction model reminiscent of systemic inflammation and organ interaction in heart failure preserved ejection fraction (HFpEF) patientsWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-10-24Full publication date if available
- Authors
-
Rong Zhou, Yiyuan Xia, Zheng Li, Li‐Da Wu, Yi Shi, Zhiyu Ling, Junxia ZhangList of authors in order
- Landing page
-
https://doi.org/10.21203/rs.3.rs-2183043/v1Publisher landing page
- PDF URL
-
https://www.researchsquare.com/article/rs-2183043/latest.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
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https://www.researchsquare.com/article/rs-2183043/latest.pdfDirect OA link when available
- Concepts
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Medicine, Internal medicine, Heart failure with preserved ejection fraction, Cardiology, Heart failure, Atrial fibrillation, Brier score, Logistic regression, Ejection fraction, Artificial intelligence, Computer scienceTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1Per-year citation counts (last 5 years)
- References (count)
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54Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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