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Development and validation of bioanalytical method for amlodipine in human plasma with optimised extraction method using Design of Experiment (DOE)
January 2015 • Abul Bashar Mohammed Helaluddin, Mohamed Alaama, Huda Jamilah Mohamad, N. S. Amirudin
Amlodipine is antihypertensive drug belonging to calcium antagonist group. This study aims to apply experimental design for the optimization of extraction method of amlodipine from human plasma for higher and constant recovery. A chromatographic method involving HPLC (High Performance Liquid Chromatography) with DAD (Diode Array Detector) was developed and validated for the determination of Amlodipine in human plasma with cetirizine as internal standard. Sample preparation for the extraction of Amlodipine and Ceti…
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Chromatography
Extraction (Chemistry)
High-Performance Liquid Chromatography
Chemistry
Factorial Experiment
Design Of Experiments
Solvent
Response Surface Methodology
Computer Science
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Mathematics
Machine Learning
Statistics
Blood Pressure
Medicine
Radiology
Organic Chemistry
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