Development and validation of the Normalized Organoid Growth Rate (NOGR) metric in brightfield imaging-based assays Article Swipe
Christophe Deben
,
Edgar Cardenas De La Hoz
,
Felicia Rodrigues Fortes
,
Maxim Le Compte
,
Sofie Seghers
,
Steve Vanlanduit
,
H. Vercammen
,
Bert Van Den Bogert
,
Nelson Dusetti
,
Abraham Lin
,
Geert Roeyen
,
Marc Peeters
,
Hans Prenen
,
Filip Lardon
,
Evelien Smits
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1038/s42003-024-07329-5
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1038/s42003-024-07329-5
This study focuses on refining growth-rate-based drug response metrics for patient-derived tumor organoid screening using brightfield live-cell imaging. Traditional metrics like Normalized Growth Rate Inhibition (GR) and Normalized Drug Response (NDR) have been used to assess organoid responses to anticancer treatments but face limitations in accurately quantifying cytostatic and cytotoxic effects across varying growth rates. Here, we introduce the Normalized Organoid Growth Rate (NOGR) metric, specifically developed for brightfield imaging-based assays. A label-free image analysis model was applied to segment organoids precisely, track their growth rates over time, and classify viable and dead organoids. Testing eleven phenotypically distinct pancreatic cancer organoid models with five chemotherapeutics demonstrates that the NOGR metric more effectively captures cytostatic and cytotoxic drug effects compared to existing methods. This approach enhances the biological relevance of drug sensitivity assessments on organoids and offers a valuable tool for advancing personalized cancer treatment strategies.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s42003-024-07329-5
- OA Status
- gold
- Cited By
- 5
- References
- 26
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4404949634
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4404949634Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1038/s42003-024-07329-5Digital Object Identifier
- Title
-
Development and validation of the Normalized Organoid Growth Rate (NOGR) metric in brightfield imaging-based assaysWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-12-03Full publication date if available
- Authors
-
Christophe Deben, Edgar Cardenas De La Hoz, Felicia Rodrigues Fortes, Maxim Le Compte, Sofie Seghers, Steve Vanlanduit, H. Vercammen, Bert Van Den Bogert, Nelson Dusetti, Abraham Lin, Geert Roeyen, Marc Peeters, Hans Prenen, Filip Lardon, Evelien SmitsList of authors in order
- Landing page
-
https://doi.org/10.1038/s42003-024-07329-5Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1038/s42003-024-07329-5Direct OA link when available
- Concepts
-
Organoid, Metric (unit), Drug response, Biology, Drug discovery, Biomedical engineering, Drug, Computational biology, Bioinformatics, Medicine, Pharmacology, Cell biology, Operations management, EconomicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
5Total citation count in OpenAlex
- Citations by year (recent)
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2025: 5Per-year citation counts (last 5 years)
- References (count)
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26Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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