Development of a Static Avascular and Dynamic Vascular Human Skin Equivalent Employing Collagen/Keratin Hydrogels Article Swipe
Kameel Zuniga
,
Neda Ghousifam
,
Lucy Shaffer
,
Sean Brocklehurst
,
Mark Van Dyke
,
Robert J. Christy
,
Shanmugasundaram Natesan
,
Marissa Nichole Rylander
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/ijms25094992
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/ijms25094992
One of the primary complications in generating physiologically representative skin tissue is the inability to integrate vasculature into the system, which has been shown to promote the proliferation of basal keratinocytes and consequent keratinocyte differentiation, and is necessary for mimicking representative barrier function in the skin and physiological transport properties. We created a 3D vascularized human skin equivalent (VHSE) with a dermal and epidermal layer, and compared keratinocyte differentiation (immunomarker staining), epidermal thickness (H&E staining), and barrier function (transepithelial electrical resistance (TEER) and dextran permeability) to a static, organotypic avascular HSE (AHSE). The VHSE had a significantly thicker epidermal layer and increased resistance, both an indication of increased barrier function, compared to the AHSE. The inclusion of keratin in our collagen hydrogel extracellular matrix (ECM) increased keratinocyte differentiation and barrier function, indicated by greater resistance and decreased permeability. Surprisingly, however, endothelial cells grown in a collagen/keratin extracellular environment showed increased cell growth and decreased vascular permeability, indicating a more confluent and tighter vessel compared to those grown in a pure collagen environment. The development of a novel VHSE, which incorporated physiological vasculature and a unique collagen/keratin ECM, improved barrier function, vessel development, and skin structure compared to a static AHSE model.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms25094992
- https://www.mdpi.com/1422-0067/25/9/4992/pdf?version=1714720858
- OA Status
- gold
- Cited By
- 1
- References
- 61
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4396623793
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4396623793Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/ijms25094992Digital Object Identifier
- Title
-
Development of a Static Avascular and Dynamic Vascular Human Skin Equivalent Employing Collagen/Keratin HydrogelsWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2024Year of publication
- Publication date
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2024-05-03Full publication date if available
- Authors
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Kameel Zuniga, Neda Ghousifam, Lucy Shaffer, Sean Brocklehurst, Mark Van Dyke, Robert J. Christy, Shanmugasundaram Natesan, Marissa Nichole RylanderList of authors in order
- Landing page
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https://doi.org/10.3390/ijms25094992Publisher landing page
- PDF URL
-
https://www.mdpi.com/1422-0067/25/9/4992/pdf?version=1714720858Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/1422-0067/25/9/4992/pdf?version=1714720858Direct OA link when available
- Concepts
-
Keratin, Extracellular matrix, Keratinocyte, Barrier function, Skin equivalent, Cell biology, Chemistry, Human skin, Pathology, Biology, Biochemistry, In vitro, Medicine, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
- Citations by year (recent)
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2024: 1Per-year citation counts (last 5 years)
- References (count)
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61Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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