Development of antifibrotic therapy for stricturing Crohn’s disease: lessons from randomized trials in other fibrotic diseases Article Swipe
Sinan Lin
,
Ren Mao
,
Chenchen Qian
,
Dominik Bettenworth
,
Jie Wang
,
Jiannan Li
,
David H. Bruining
,
Vipul Jairath
,
Brian G. Feagan
,
Minhu Chen
,
Florian Rieder
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1152/physrev.00005.2021
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1152/physrev.00005.2021
Intestinal fibrosis is considered an inevitable complication of Crohn’s disease (CD) that results in symptoms of obstruction and stricture formation. Endoscopic or surgical treatment is required to treat the majority of patients. Progress in the management of stricturing CD is hampered by the lack of effective antifibrotic therapy; however, this situation is likely to change because of recent advances in other fibrotic diseases of the lung, liver, and skin. In this review, we summarize data from randomized controlled trials (RCTs) of antifibrotic therapies in these conditions. Multiple compounds have been tested for antifibrotic effects in other organs. According to their mechanisms, they were categorized into growth factor modulators, inflammation modulators, 5-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, intracellular enzymes and kinases, renin-angiotensin system (RAS) modulators, and others. From our review of the results from the clinical trials and discussion of their implications in the gastrointestinal tract, we have identified several molecular candidates that could serve as potential therapies for intestinal fibrosis in CD.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1152/physrev.00005.2021
- OA Status
- green
- Cited By
- 62
- References
- 539
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3203780103
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3203780103Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1152/physrev.00005.2021Digital Object Identifier
- Title
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Development of antifibrotic therapy for stricturing Crohn’s disease: lessons from randomized trials in other fibrotic diseasesWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2021Year of publication
- Publication date
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2021-09-27Full publication date if available
- Authors
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Sinan Lin, Ren Mao, Chenchen Qian, Dominik Bettenworth, Jie Wang, Jiannan Li, David H. Bruining, Vipul Jairath, Brian G. Feagan, Minhu Chen, Florian RiederList of authors in order
- Landing page
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https://doi.org/10.1152/physrev.00005.2021Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
- OA URL
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https://www.ncbi.nlm.nih.gov/pmc/articles/8742742Direct OA link when available
- Concepts
-
Medicine, Crohn's disease, Fibrosis, Randomized controlled trial, Disease, Internal medicine, Clinical trial, Inflammation, GastroenterologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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62Total citation count in OpenAlex
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2025: 14, 2024: 24, 2023: 19, 2022: 5Per-year citation counts (last 5 years)
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539Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.fibrosis | 1, 158 |
| abstract_inverted_index.fibrotic | 61 |
| abstract_inverted_index.hampered | 40 |
| abstract_inverted_index.however, | 48 |
| abstract_inverted_index.kinases, | 118 |
| abstract_inverted_index.majority | 29 |
| abstract_inverted_index.required | 25 |
| abstract_inverted_index.surgical | 22 |
| abstract_inverted_index.symptoms | 14 |
| abstract_inverted_index.therapy; | 47 |
| abstract_inverted_index.(HMG-CoA) | 112 |
| abstract_inverted_index.According | 97 |
| abstract_inverted_index.Crohn’s | 8 |
| abstract_inverted_index.compounds | 87 |
| abstract_inverted_index.effective | 45 |
| abstract_inverted_index.molecular | 148 |
| abstract_inverted_index.patients. | 31 |
| abstract_inverted_index.potential | 154 |
| abstract_inverted_index.reductase | 113 |
| abstract_inverted_index.situation | 50 |
| abstract_inverted_index.stricture | 18 |
| abstract_inverted_index.summarize | 73 |
| abstract_inverted_index.therapies | 82, 155 |
| abstract_inverted_index.treatment | 23 |
| abstract_inverted_index.Endoscopic | 20 |
| abstract_inverted_index.Intestinal | 0 |
| abstract_inverted_index.candidates | 149 |
| abstract_inverted_index.considered | 3 |
| abstract_inverted_index.controlled | 77 |
| abstract_inverted_index.discussion | 136 |
| abstract_inverted_index.formation. | 19 |
| abstract_inverted_index.identified | 146 |
| abstract_inverted_index.inevitable | 5 |
| abstract_inverted_index.intestinal | 157 |
| abstract_inverted_index.management | 35 |
| abstract_inverted_index.randomized | 76 |
| abstract_inverted_index.categorized | 103 |
| abstract_inverted_index.conditions. | 85 |
| abstract_inverted_index.inhibitors, | 114 |
| abstract_inverted_index.mechanisms, | 100 |
| abstract_inverted_index.modulators, | 107, 109, 122 |
| abstract_inverted_index.obstruction | 16 |
| abstract_inverted_index.stricturing | 37 |
| abstract_inverted_index.antifibrotic | 46, 81, 92 |
| abstract_inverted_index.complication | 6 |
| abstract_inverted_index.implications | 139 |
| abstract_inverted_index.inflammation | 108 |
| abstract_inverted_index.intracellular | 115 |
| abstract_inverted_index.gastrointestinal | 142 |
| abstract_inverted_index.renin-angiotensin | 119 |
| abstract_inverted_index.5-hydroxy-3-methylglutaryl-coenzyme | 110 |
| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 97 |
| corresponding_author_ids | https://openalex.org/A5012305407 |
| countries_distinct_count | 4 |
| institutions_distinct_count | 11 |
| corresponding_institution_ids | https://openalex.org/I1316902750, https://openalex.org/I36373038 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8299999833106995 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.9795792 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |