Development of binary dispersions and nanocomposites of irbesartan with enhanced antihypertensive activity Article Swipe
Vivek Puri
,
Manju Nagpal
,
Ameya Sharma
,
Thakur Gurjeet Singh
,
Manjinder Singh
,
Geeta Aggarwal
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.34172/bi.2020.34
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.34172/bi.2020.34
Introduction: Irbesartan (IBS), an angiotensin II receptor (AT1 subtype) antagonist which blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selective binding to AT1 angiotensin II receptor. It belongs to BCS class II drug (low aqueous solubility and high permeability). Improvement of dissolution characteristics of the drug by formulating is being investigated in the current study. Methods: Solid dispersions (SD) formulations were prepared by the melting fusion technique and nanocomposites (NC) were prepared by a single emulsion technique. Eight batches of SD and three batches of NC were formulated in three ratios of drug to polymer (1:1, 1:2, and 1:3). The batches were evaluated for equilibrium solubility studies, Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), field emission SEM (FESEM), transmission electron microscopy (TEM), and in vitro dissolution studies. Results: Solubility studies revealed maximum solubility at a 1:2 ratio of solid dispersions and a 1:1 ratio of nanocomposites. No drug-polymer interaction was observed in FTIR results. DSC, SEM, and XRD analysis revealed changes in drug crystallinity i.e. conversion to the amorphous state of drugs. Nanosize of particles in the NC1 batch was confirmed in TEM studies. Solid dispersions and nanocomposites showed significant enhancement of dissolution in comparison to that of the pure drug (100% drug release in approximately 1 hour). Conclusion: Nanocomposites proved superior carriers to solid dispersions in terms of the dissolution enhancement. Further, in vivo studies indicated that the induction of systolic and diastolic blood pressure in the optimized formulation (NC1) was significantly decreased in comparison to the disease control group ( P <0.01) at all time intervals along with pure drug ( P <0.05).
Related Topics
Concepts
Solubility
Differential scanning calorimetry
Dissolution
Fourier transform infrared spectroscopy
Materials science
Irbesartan
Crystallinity
Chemical engineering
Nuclear chemistry
Chemistry
Organic chemistry
Medicine
Alternative medicine
Thermodynamics
Engineering
Composite material
Pathology
Physics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.34172/bi.2020.34
- OA Status
- diamond
- Cited By
- 6
- References
- 35
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3086610332
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3086610332Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.34172/bi.2020.34Digital Object Identifier
- Title
-
Development of binary dispersions and nanocomposites of irbesartan with enhanced antihypertensive activityWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2019Year of publication
- Publication date
-
2019-11-25Full publication date if available
- Authors
-
Vivek Puri, Manju Nagpal, Ameya Sharma, Thakur Gurjeet Singh, Manjinder Singh, Geeta AggarwalList of authors in order
- Landing page
-
https://doi.org/10.34172/bi.2020.34Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.34172/bi.2020.34Direct OA link when available
- Concepts
-
Solubility, Differential scanning calorimetry, Dissolution, Fourier transform infrared spectroscopy, Materials science, Irbesartan, Crystallinity, Chemical engineering, Nuclear chemistry, Chemistry, Organic chemistry, Medicine, Alternative medicine, Thermodynamics, Engineering, Composite material, Pathology, PhysicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
6Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2023: 2, 2022: 1, 2021: 1Per-year citation counts (last 5 years)
- References (count)
-
35Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3086610332 |
|---|---|
| doi | https://doi.org/10.34172/bi.2020.34 |
| ids.doi | https://doi.org/10.34172/bi.2020.34 |
| ids.mag | 3086610332 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/32983943 |
| ids.openalex | https://openalex.org/W3086610332 |
| fwci | 0.22183063 |
| type | article |
| title | Development of binary dispersions and nanocomposites of irbesartan with enhanced antihypertensive activity |
| biblio.issue | 4 |
| biblio.volume | 10 |
| biblio.last_page | 278 |
| biblio.first_page | 269 |
| topics[0].id | https://openalex.org/T10256 |
| topics[0].field.id | https://openalex.org/fields/30 |
| topics[0].field.display_name | Pharmacology, Toxicology and Pharmaceutics |
| topics[0].score | 0.9998999834060669 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/3003 |
| topics[0].subfield.display_name | Pharmaceutical Science |
| topics[0].display_name | Drug Solubulity and Delivery Systems |
| topics[1].id | https://openalex.org/T11460 |
| topics[1].field.id | https://openalex.org/fields/16 |
| topics[1].field.display_name | Chemistry |
| topics[1].score | 0.9987000226974487 |
| topics[1].domain.id | https://openalex.org/domains/3 |
| topics[1].domain.display_name | Physical Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1602 |
| topics[1].subfield.display_name | Analytical Chemistry |
| topics[1].display_name | Analytical Methods in Pharmaceuticals |
| topics[2].id | https://openalex.org/T11881 |
| topics[2].field.id | https://openalex.org/fields/25 |
| topics[2].field.display_name | Materials Science |
| topics[2].score | 0.9980000257492065 |
| topics[2].domain.id | https://openalex.org/domains/3 |
| topics[2].domain.display_name | Physical Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2505 |
| topics[2].subfield.display_name | Materials Chemistry |
| topics[2].display_name | Crystallization and Solubility Studies |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C155574463 |
| concepts[0].level | 2 |
| concepts[0].score | 0.7720367908477783 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q170731 |
| concepts[0].display_name | Solubility |
| concepts[1].id | https://openalex.org/C39519442 |
| concepts[1].level | 2 |
| concepts[1].score | 0.7011272311210632 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q904893 |
| concepts[1].display_name | Differential scanning calorimetry |
| concepts[2].id | https://openalex.org/C88380143 |
| concepts[2].level | 2 |
| concepts[2].score | 0.6759743690490723 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q416674 |
| concepts[2].display_name | Dissolution |
| concepts[3].id | https://openalex.org/C160892712 |
| concepts[3].level | 2 |
| concepts[3].score | 0.5974462032318115 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q901559 |
| concepts[3].display_name | Fourier transform infrared spectroscopy |
| concepts[4].id | https://openalex.org/C192562407 |
| concepts[4].level | 0 |
| concepts[4].score | 0.5789912939071655 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q228736 |
| concepts[4].display_name | Materials science |
| concepts[5].id | https://openalex.org/C2780259554 |
| concepts[5].level | 3 |
| concepts[5].score | 0.5232597589492798 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q947266 |
| concepts[5].display_name | Irbesartan |
| concepts[6].id | https://openalex.org/C46275449 |
| concepts[6].level | 2 |
| concepts[6].score | 0.4937048852443695 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q2458815 |
| concepts[6].display_name | Crystallinity |
| concepts[7].id | https://openalex.org/C42360764 |
| concepts[7].level | 1 |
| concepts[7].score | 0.443376362323761 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q83588 |
| concepts[7].display_name | Chemical engineering |
| concepts[8].id | https://openalex.org/C13965031 |
| concepts[8].level | 1 |
| concepts[8].score | 0.3812168836593628 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q243545 |
| concepts[8].display_name | Nuclear chemistry |
| concepts[9].id | https://openalex.org/C185592680 |
| concepts[9].level | 0 |
| concepts[9].score | 0.3619078993797302 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[9].display_name | Chemistry |
| concepts[10].id | https://openalex.org/C178790620 |
| concepts[10].level | 1 |
| concepts[10].score | 0.18488574028015137 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q11351 |
| concepts[10].display_name | Organic chemistry |
| concepts[11].id | https://openalex.org/C71924100 |
| concepts[11].level | 0 |
| concepts[11].score | 0.11393791437149048 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[11].display_name | Medicine |
| concepts[12].id | https://openalex.org/C204787440 |
| concepts[12].level | 2 |
| concepts[12].score | 0.0 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q188504 |
| concepts[12].display_name | Alternative medicine |
| concepts[13].id | https://openalex.org/C97355855 |
| concepts[13].level | 1 |
| concepts[13].score | 0.0 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q11473 |
| concepts[13].display_name | Thermodynamics |
| concepts[14].id | https://openalex.org/C127413603 |
| concepts[14].level | 0 |
| concepts[14].score | 0.0 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q11023 |
| concepts[14].display_name | Engineering |
| concepts[15].id | https://openalex.org/C159985019 |
| concepts[15].level | 1 |
| concepts[15].score | 0.0 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q181790 |
| concepts[15].display_name | Composite material |
| concepts[16].id | https://openalex.org/C142724271 |
| concepts[16].level | 1 |
| concepts[16].score | 0.0 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q7208 |
| concepts[16].display_name | Pathology |
| concepts[17].id | https://openalex.org/C121332964 |
| concepts[17].level | 0 |
| concepts[17].score | 0.0 |
| concepts[17].wikidata | https://www.wikidata.org/wiki/Q413 |
| concepts[17].display_name | Physics |
| keywords[0].id | https://openalex.org/keywords/solubility |
| keywords[0].score | 0.7720367908477783 |
| keywords[0].display_name | Solubility |
| keywords[1].id | https://openalex.org/keywords/differential-scanning-calorimetry |
| keywords[1].score | 0.7011272311210632 |
| keywords[1].display_name | Differential scanning calorimetry |
| keywords[2].id | https://openalex.org/keywords/dissolution |
| keywords[2].score | 0.6759743690490723 |
| keywords[2].display_name | Dissolution |
| keywords[3].id | https://openalex.org/keywords/fourier-transform-infrared-spectroscopy |
| keywords[3].score | 0.5974462032318115 |
| keywords[3].display_name | Fourier transform infrared spectroscopy |
| keywords[4].id | https://openalex.org/keywords/materials-science |
| keywords[4].score | 0.5789912939071655 |
| keywords[4].display_name | Materials science |
| keywords[5].id | https://openalex.org/keywords/irbesartan |
| keywords[5].score | 0.5232597589492798 |
| keywords[5].display_name | Irbesartan |
| keywords[6].id | https://openalex.org/keywords/crystallinity |
| keywords[6].score | 0.4937048852443695 |
| keywords[6].display_name | Crystallinity |
| keywords[7].id | https://openalex.org/keywords/chemical-engineering |
| keywords[7].score | 0.443376362323761 |
| keywords[7].display_name | Chemical engineering |
| keywords[8].id | https://openalex.org/keywords/nuclear-chemistry |
| keywords[8].score | 0.3812168836593628 |
| keywords[8].display_name | Nuclear chemistry |
| keywords[9].id | https://openalex.org/keywords/chemistry |
| keywords[9].score | 0.3619078993797302 |
| keywords[9].display_name | Chemistry |
| keywords[10].id | https://openalex.org/keywords/organic-chemistry |
| keywords[10].score | 0.18488574028015137 |
| keywords[10].display_name | Organic chemistry |
| keywords[11].id | https://openalex.org/keywords/medicine |
| keywords[11].score | 0.11393791437149048 |
| keywords[11].display_name | Medicine |
| language | en |
| locations[0].id | doi:10.34172/bi.2020.34 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4210202379 |
| locations[0].source.issn | 2228-5652, 2228-5660 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2228-5652 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Bioimpacts |
| locations[0].source.host_organization | https://openalex.org/P4310319102 |
| locations[0].source.host_organization_name | Tabriz University of Medical Sciences |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310319102 |
| locations[0].source.host_organization_lineage_names | Tabriz University of Medical Sciences |
| locations[0].license | cc-by-nc |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by-nc |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | BioImpacts |
| locations[0].landing_page_url | https://doi.org/10.34172/bi.2020.34 |
| locations[1].id | pmid:32983943 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | BioImpacts : BI |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/32983943 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:7502911 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | publishedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | True |
| locations[2].is_published | True |
| locations[2].raw_source_name | Bioimpacts |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/7502911 |
| locations[3].id | pmh:oai:doaj.org/article:9215e38748784a388251dbd90787c5f9 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S4306401280 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[3].source.host_organization | |
| locations[3].source.host_organization_name | |
| locations[3].license | cc-by-sa |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | article |
| locations[3].license_id | https://openalex.org/licenses/cc-by-sa |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | BioImpacts, Vol 10, Iss 4, Pp 269-278 (2020) |
| locations[3].landing_page_url | https://doaj.org/article/9215e38748784a388251dbd90787c5f9 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5004565046 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-4497-9412 |
| authorships[0].author.display_name | Vivek Puri |
| authorships[0].countries | IN |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I74319210 |
| authorships[0].affiliations[0].raw_affiliation_string | Chitkara College of Pharmacy, Chitkara University, Punjab, India |
| authorships[0].institutions[0].id | https://openalex.org/I74319210 |
| authorships[0].institutions[0].ror | https://ror.org/057d6z539 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I74319210 |
| authorships[0].institutions[0].country_code | IN |
| authorships[0].institutions[0].display_name | Chitkara University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Vivek Puri |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Chitkara College of Pharmacy, Chitkara University, Punjab, India |
| authorships[1].author.id | https://openalex.org/A5019365815 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-3503-6743 |
| authorships[1].author.display_name | Manju Nagpal |
| authorships[1].countries | IN |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I74319210 |
| authorships[1].affiliations[0].raw_affiliation_string | Chitkara College of Pharmacy, Chitkara University, Punjab, India |
| authorships[1].institutions[0].id | https://openalex.org/I74319210 |
| authorships[1].institutions[0].ror | https://ror.org/057d6z539 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I74319210 |
| authorships[1].institutions[0].country_code | IN |
| authorships[1].institutions[0].display_name | Chitkara University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Manju Nagpal |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Chitkara College of Pharmacy, Chitkara University, Punjab, India |
| authorships[2].author.id | https://openalex.org/A5060120800 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-3810-4238 |
| authorships[2].author.display_name | Ameya Sharma |
| authorships[2].countries | IN |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I74319210 |
| authorships[2].affiliations[0].raw_affiliation_string | Chitkara College of Pharmacy, Chitkara University, Punjab, India |
| authorships[2].institutions[0].id | https://openalex.org/I74319210 |
| authorships[2].institutions[0].ror | https://ror.org/057d6z539 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I74319210 |
| authorships[2].institutions[0].country_code | IN |
| authorships[2].institutions[0].display_name | Chitkara University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Ameya Sharma |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Chitkara College of Pharmacy, Chitkara University, Punjab, India |
| authorships[3].author.id | https://openalex.org/A5016919399 |
| authorships[3].author.orcid | https://orcid.org/0000-0003-2979-1590 |
| authorships[3].author.display_name | Thakur Gurjeet Singh |
| authorships[3].countries | IN |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I74319210 |
| authorships[3].affiliations[0].raw_affiliation_string | Chitkara College of Pharmacy, Chitkara University, Punjab, India |
| authorships[3].institutions[0].id | https://openalex.org/I74319210 |
| authorships[3].institutions[0].ror | https://ror.org/057d6z539 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I74319210 |
| authorships[3].institutions[0].country_code | IN |
| authorships[3].institutions[0].display_name | Chitkara University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Gurjeet Singh Thakur |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Chitkara College of Pharmacy, Chitkara University, Punjab, India |
| authorships[4].author.id | https://openalex.org/A5102887621 |
| authorships[4].author.orcid | https://orcid.org/0000-0001-5477-9222 |
| authorships[4].author.display_name | Manjinder Singh |
| authorships[4].countries | IN |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I74319210 |
| authorships[4].affiliations[0].raw_affiliation_string | Chitkara College of Pharmacy, Chitkara University, Punjab, India |
| authorships[4].institutions[0].id | https://openalex.org/I74319210 |
| authorships[4].institutions[0].ror | https://ror.org/057d6z539 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I74319210 |
| authorships[4].institutions[0].country_code | IN |
| authorships[4].institutions[0].display_name | Chitkara University |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Manjinder Singh |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Chitkara College of Pharmacy, Chitkara University, Punjab, India |
| authorships[5].author.id | https://openalex.org/A5082597842 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-0568-4267 |
| authorships[5].author.display_name | Geeta Aggarwal |
| authorships[5].countries | IN |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I39238937 |
| authorships[5].affiliations[0].raw_affiliation_string | Delhi Pharmaceutical Sciences and Research University, New Delhi-110017, India |
| authorships[5].institutions[0].id | https://openalex.org/I39238937 |
| authorships[5].institutions[0].ror | https://ror.org/022akpv96 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I39238937 |
| authorships[5].institutions[0].country_code | IN |
| authorships[5].institutions[0].display_name | Delhi Pharmaceutical Science and Research University |
| authorships[5].author_position | last |
| authorships[5].raw_author_name | Geeta Aggarwal |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Delhi Pharmaceutical Sciences and Research University, New Delhi-110017, India |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.34172/bi.2020.34 |
| open_access.oa_status | diamond |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Development of binary dispersions and nanocomposites of irbesartan with enhanced antihypertensive activity |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10256 |
| primary_topic.field.id | https://openalex.org/fields/30 |
| primary_topic.field.display_name | Pharmacology, Toxicology and Pharmaceutics |
| primary_topic.score | 0.9998999834060669 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/3003 |
| primary_topic.subfield.display_name | Pharmaceutical Science |
| primary_topic.display_name | Drug Solubulity and Delivery Systems |
| related_works | https://openalex.org/W2416592866, https://openalex.org/W2369831138, https://openalex.org/W2349328099, https://openalex.org/W2158848760, https://openalex.org/W2363556367, https://openalex.org/W2035691576, https://openalex.org/W2368822462, https://openalex.org/W2367777554, https://openalex.org/W2378180018, https://openalex.org/W2353722136 |
| cited_by_count | 6 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 2 |
| counts_by_year[1].year | 2023 |
| counts_by_year[1].cited_by_count | 2 |
| counts_by_year[2].year | 2022 |
| counts_by_year[2].cited_by_count | 1 |
| counts_by_year[3].year | 2021 |
| counts_by_year[3].cited_by_count | 1 |
| locations_count | 4 |
| best_oa_location.id | doi:10.34172/bi.2020.34 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4210202379 |
| best_oa_location.source.issn | 2228-5652, 2228-5660 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2228-5652 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Bioimpacts |
| best_oa_location.source.host_organization | https://openalex.org/P4310319102 |
| best_oa_location.source.host_organization_name | Tabriz University of Medical Sciences |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310319102 |
| best_oa_location.source.host_organization_lineage_names | Tabriz University of Medical Sciences |
| best_oa_location.license | cc-by-nc |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by-nc |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | BioImpacts |
| best_oa_location.landing_page_url | https://doi.org/10.34172/bi.2020.34 |
| primary_location.id | doi:10.34172/bi.2020.34 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4210202379 |
| primary_location.source.issn | 2228-5652, 2228-5660 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2228-5652 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Bioimpacts |
| primary_location.source.host_organization | https://openalex.org/P4310319102 |
| primary_location.source.host_organization_name | Tabriz University of Medical Sciences |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310319102 |
| primary_location.source.host_organization_lineage_names | Tabriz University of Medical Sciences |
| primary_location.license | cc-by-nc |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by-nc |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | BioImpacts |
| primary_location.landing_page_url | https://doi.org/10.34172/bi.2020.34 |
| publication_date | 2019-11-25 |
| publication_year | 2019 |
| referenced_works | https://openalex.org/W2165354811, https://openalex.org/W2005893499, https://openalex.org/W2160996409, https://openalex.org/W1970084786, https://openalex.org/W2034277254, https://openalex.org/W2126209235, https://openalex.org/W2014782282, https://openalex.org/W2022429137, https://openalex.org/W2291656378, https://openalex.org/W2085769595, https://openalex.org/W2369933822, https://openalex.org/W2182710151, https://openalex.org/W2187351689, https://openalex.org/W2058579877, https://openalex.org/W2125916785, https://openalex.org/W2163196876, https://openalex.org/W2921185265, https://openalex.org/W2004600013, https://openalex.org/W2119847082, https://openalex.org/W2803247155, https://openalex.org/W2897133532, https://openalex.org/W2894230534, https://openalex.org/W2892094182, https://openalex.org/W2111965899, https://openalex.org/W2168339235, https://openalex.org/W6720171678, https://openalex.org/W2064967117, https://openalex.org/W2001714357, https://openalex.org/W4247631405, https://openalex.org/W2174293826, https://openalex.org/W2132081026, https://openalex.org/W1987960532, https://openalex.org/W4285719527, https://openalex.org/W2118436621, https://openalex.org/W3147290171 |
| referenced_works_count | 35 |
| abstract_inverted_index.( | 261, 272 |
| abstract_inverted_index.1 | 216 |
| abstract_inverted_index.P | 262, 273 |
| abstract_inverted_index.a | 75, 144, 151 |
| abstract_inverted_index.II | 5, 19, 26, 33 |
| abstract_inverted_index.It | 28 |
| abstract_inverted_index.NC | 87 |
| abstract_inverted_index.No | 156 |
| abstract_inverted_index.SD | 82 |
| abstract_inverted_index.an | 3 |
| abstract_inverted_index.at | 143, 264 |
| abstract_inverted_index.by | 20, 48, 64, 74 |
| abstract_inverted_index.in | 53, 90, 133, 161, 171, 185, 191, 203, 214, 226, 233, 246, 254 |
| abstract_inverted_index.is | 50 |
| abstract_inverted_index.of | 17, 42, 45, 81, 86, 93, 147, 154, 180, 183, 201, 207, 228, 240 |
| abstract_inverted_index.to | 23, 30, 95, 176, 205, 223, 256 |
| abstract_inverted_index.1:1 | 152 |
| abstract_inverted_index.1:2 | 145 |
| abstract_inverted_index.AT1 | 24 |
| abstract_inverted_index.BCS | 31 |
| abstract_inverted_index.NC1 | 187 |
| abstract_inverted_index.SEM | 126 |
| abstract_inverted_index.TEM | 192 |
| abstract_inverted_index.The | 101 |
| abstract_inverted_index.XRD | 167 |
| abstract_inverted_index.all | 265 |
| abstract_inverted_index.and | 14, 38, 69, 83, 99, 132, 150, 166, 196, 242 |
| abstract_inverted_index.for | 105 |
| abstract_inverted_index.the | 12, 46, 54, 65, 177, 186, 208, 229, 238, 247, 257 |
| abstract_inverted_index.was | 159, 189, 251 |
| abstract_inverted_index.(AT1 | 7 |
| abstract_inverted_index.(NC) | 71 |
| abstract_inverted_index.(SD) | 60 |
| abstract_inverted_index.(low | 35 |
| abstract_inverted_index.1:2, | 98 |
| abstract_inverted_index.DSC, | 164 |
| abstract_inverted_index.FTIR | 162 |
| abstract_inverted_index.SEM, | 165 |
| abstract_inverted_index.drug | 34, 47, 94, 172, 210, 212, 271 |
| abstract_inverted_index.high | 39 |
| abstract_inverted_index.i.e. | 174 |
| abstract_inverted_index.pure | 209, 270 |
| abstract_inverted_index.that | 206, 237 |
| abstract_inverted_index.time | 266 |
| abstract_inverted_index.vivo | 234 |
| abstract_inverted_index.were | 62, 72, 88, 103 |
| abstract_inverted_index.with | 269 |
| abstract_inverted_index.(100% | 211 |
| abstract_inverted_index.(1:1, | 97 |
| abstract_inverted_index.(NC1) | 250 |
| abstract_inverted_index.1:3). | 100 |
| abstract_inverted_index.Eight | 79 |
| abstract_inverted_index.Solid | 58, 194 |
| abstract_inverted_index.X-ray | 117 |
| abstract_inverted_index.along | 268 |
| abstract_inverted_index.batch | 188 |
| abstract_inverted_index.being | 51 |
| abstract_inverted_index.blood | 244 |
| abstract_inverted_index.class | 32 |
| abstract_inverted_index.field | 124 |
| abstract_inverted_index.group | 260 |
| abstract_inverted_index.ratio | 146, 153 |
| abstract_inverted_index.solid | 148, 224 |
| abstract_inverted_index.state | 179 |
| abstract_inverted_index.terms | 227 |
| abstract_inverted_index.three | 84, 91 |
| abstract_inverted_index.vitro | 134 |
| abstract_inverted_index.which | 10 |
| abstract_inverted_index.(DSC), | 116 |
| abstract_inverted_index.(IBS), | 2 |
| abstract_inverted_index.(SEM), | 123 |
| abstract_inverted_index.(TEM), | 131 |
| abstract_inverted_index.(XRD), | 119 |
| abstract_inverted_index.blocks | 11 |
| abstract_inverted_index.drugs. | 181 |
| abstract_inverted_index.fusion | 67 |
| abstract_inverted_index.hour). | 217 |
| abstract_inverted_index.proved | 220 |
| abstract_inverted_index.ratios | 92 |
| abstract_inverted_index.showed | 198 |
| abstract_inverted_index.single | 76 |
| abstract_inverted_index.study. | 56 |
| abstract_inverted_index.(FTIR), | 112 |
| abstract_inverted_index.aqueous | 36 |
| abstract_inverted_index.batches | 80, 85, 102 |
| abstract_inverted_index.belongs | 29 |
| abstract_inverted_index.binding | 22 |
| abstract_inverted_index.changes | 170 |
| abstract_inverted_index.control | 259 |
| abstract_inverted_index.current | 55 |
| abstract_inverted_index.disease | 258 |
| abstract_inverted_index.effects | 16 |
| abstract_inverted_index.maximum | 141 |
| abstract_inverted_index.melting | 66 |
| abstract_inverted_index.polymer | 96 |
| abstract_inverted_index.release | 213 |
| abstract_inverted_index.studies | 139, 235 |
| abstract_inverted_index.(FESEM), | 127 |
| abstract_inverted_index.Further, | 232 |
| abstract_inverted_index.Methods: | 57 |
| abstract_inverted_index.Nanosize | 182 |
| abstract_inverted_index.Results: | 137 |
| abstract_inverted_index.analysis | 168 |
| abstract_inverted_index.carriers | 222 |
| abstract_inverted_index.electron | 121, 129 |
| abstract_inverted_index.emission | 125 |
| abstract_inverted_index.emulsion | 77 |
| abstract_inverted_index.infrared | 110 |
| abstract_inverted_index.observed | 160 |
| abstract_inverted_index.prepared | 63, 73 |
| abstract_inverted_index.pressure | 245 |
| abstract_inverted_index.receptor | 6 |
| abstract_inverted_index.results. | 163 |
| abstract_inverted_index.revealed | 140, 169 |
| abstract_inverted_index.scanning | 114, 120 |
| abstract_inverted_index.studies, | 108 |
| abstract_inverted_index.studies. | 136, 193 |
| abstract_inverted_index.subtype) | 8 |
| abstract_inverted_index.superior | 221 |
| abstract_inverted_index.systolic | 241 |
| abstract_inverted_index.<0.01) | 263 |
| abstract_inverted_index.amorphous | 178 |
| abstract_inverted_index.confirmed | 190 |
| abstract_inverted_index.decreased | 253 |
| abstract_inverted_index.diastolic | 243 |
| abstract_inverted_index.evaluated | 104 |
| abstract_inverted_index.indicated | 236 |
| abstract_inverted_index.induction | 239 |
| abstract_inverted_index.intervals | 267 |
| abstract_inverted_index.optimized | 248 |
| abstract_inverted_index.particles | 184 |
| abstract_inverted_index.receptor. | 27 |
| abstract_inverted_index.selective | 21 |
| abstract_inverted_index.technique | 68 |
| abstract_inverted_index.<0.05). | 274 |
| abstract_inverted_index.Irbesartan | 1 |
| abstract_inverted_index.Solubility | 138 |
| abstract_inverted_index.antagonist | 9 |
| abstract_inverted_index.comparison | 204, 255 |
| abstract_inverted_index.conversion | 175 |
| abstract_inverted_index.formulated | 89 |
| abstract_inverted_index.microscopy | 122, 130 |
| abstract_inverted_index.solubility | 37, 107, 142 |
| abstract_inverted_index.technique. | 78 |
| abstract_inverted_index.Conclusion: | 218 |
| abstract_inverted_index.Improvement | 41 |
| abstract_inverted_index.angiotensin | 4, 18, 25 |
| abstract_inverted_index.calorimetry | 115 |
| abstract_inverted_index.diffraction | 118 |
| abstract_inverted_index.dispersions | 59, 149, 195, 225 |
| abstract_inverted_index.dissolution | 43, 135, 202, 230 |
| abstract_inverted_index.enhancement | 200 |
| abstract_inverted_index.equilibrium | 106 |
| abstract_inverted_index.formulating | 49 |
| abstract_inverted_index.formulation | 249 |
| abstract_inverted_index.interaction | 158 |
| abstract_inverted_index.significant | 199 |
| abstract_inverted_index.differential | 113 |
| abstract_inverted_index.drug-polymer | 157 |
| abstract_inverted_index.enhancement. | 231 |
| abstract_inverted_index.formulations | 61 |
| abstract_inverted_index.investigated | 52 |
| abstract_inverted_index.spectroscopy | 111 |
| abstract_inverted_index.transmission | 128 |
| abstract_inverted_index.Introduction: | 0 |
| abstract_inverted_index.approximately | 215 |
| abstract_inverted_index.crystallinity | 173 |
| abstract_inverted_index.significantly | 252 |
| abstract_inverted_index.Nanocomposites | 219 |
| abstract_inverted_index.nanocomposites | 70, 197 |
| abstract_inverted_index.permeability). | 40 |
| abstract_inverted_index.characteristics | 44 |
| abstract_inverted_index.nanocomposites. | 155 |
| abstract_inverted_index.vasoconstrictor | 13 |
| abstract_inverted_index.Fourier-transform | 109 |
| abstract_inverted_index.aldosterone-secreting | 15 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 89 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 6 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/6 |
| sustainable_development_goals[0].score | 0.44999998807907104 |
| sustainable_development_goals[0].display_name | Clean water and sanitation |
| citation_normalized_percentile.value | 0.46553011 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |