Development of high-efficiency superparamagnetic drug delivery system with MPI imaging capability Article Swipe
Shi Bai
,
Xiaodan Zhang
,
Yuqi Zou
,
Yu-xi Lin
,
Zhiyao Liu
,
Kewen Li
,
Huang Ping
,
Takashi Yoshida
,
Yili Liu
,
Mingshan Li
,
Wei Zhang
,
Xiaoju Wang
,
Min Zhang
,
Cheng Du
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fbioe.2024.1382085
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fbioe.2024.1382085
In this study, a high-efficiency superparamagnetic drug delivery system was developed for preclinical treatment of bladder cancer in small animals. Two types of nanoparticles with magnetic particle imaging (MPI) capability, i.e., single- and multi-core superparamagnetic iron oxide nanoparticles (SPIONs), were selected and coupled with bladder anti-tumor drugs by a covalent coupling scheme. Owing to the minimal particle size, magnetic field strengths of 270 mT with a gradient of 3.2 T/m and 260 mT with a gradient of 3.7 T/m were found to be necessary to reach an average velocity of 2 mm/s for single- and multi-core SPIONs, respectively. To achieve this, a method of constructing an in vitro magnetic field for drug delivery was developed based on hollow multi-coils arranged coaxially in close rows, and magnetic field simulation was used to study the laws of the influence of the coil structure and parameters on the magnetic field. Using this method, a magnetic drug delivery system of single-core SPIONs was developed for rabbit bladder therapy. The delivery system consisted of three coaxially and equidistantly arranged coils with an inner diameter of Φ50 mm, radial height of 85 mm, and width of 15 mm that were positioned in close proximity to each other. CCK8 experimental results showed that the three types of drug-coupled SPION killed tumor cells effectively. By adjusting the axial and radial positions of the rabbit bladder within the inner hole of the delivery coil structure, the magnetic drugs injected could undergo two-dimensional delivery motions and were delivered and aggregated to the specified target location within 12 s, with an aggregation range of about 5 mm × 5 mm. In addition, the SPION distribution before and after delivery was imaged using a home-made open-bore MPI system that could realistically reflect the physical state. This study contributes to the development of local, rapid, and precise drug delivery and the visualization of this process during cancer therapy, and further research on MPI/delivery synchronization technology is planned for the future.
Related Topics
Concepts
Drug delivery
Materials science
Magnetic particle imaging
Electromagnetic coil
Magnetic nanoparticles
Magnetic field
Superparamagnetism
Targeted drug delivery
Nuclear magnetic resonance
Nanotechnology
Biomedical engineering
Nanoparticle
Physics
Medicine
Quantum mechanics
Magnetization
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fbioe.2024.1382085
- https://www.frontiersin.org/articles/10.3389/fbioe.2024.1382085/pdf?isPublishedV2=False
- OA Status
- gold
- Cited By
- 5
- References
- 73
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4393012581
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4393012581Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fbioe.2024.1382085Digital Object Identifier
- Title
-
Development of high-efficiency superparamagnetic drug delivery system with MPI imaging capabilityWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-03-20Full publication date if available
- Authors
-
Shi Bai, Xiaodan Zhang, Yuqi Zou, Yu-xi Lin, Zhiyao Liu, Kewen Li, Huang Ping, Takashi Yoshida, Yili Liu, Mingshan Li, Wei Zhang, Xiaoju Wang, Min Zhang, Cheng DuList of authors in order
- Landing page
-
https://doi.org/10.3389/fbioe.2024.1382085Publisher landing page
- PDF URL
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https://www.frontiersin.org/articles/10.3389/fbioe.2024.1382085/pdf?isPublishedV2=FalseDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.frontiersin.org/articles/10.3389/fbioe.2024.1382085/pdf?isPublishedV2=FalseDirect OA link when available
- Concepts
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Drug delivery, Materials science, Magnetic particle imaging, Electromagnetic coil, Magnetic nanoparticles, Magnetic field, Superparamagnetism, Targeted drug delivery, Nuclear magnetic resonance, Nanotechnology, Biomedical engineering, Nanoparticle, Physics, Medicine, Quantum mechanics, MagnetizationTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
5Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 4, 2024: 1Per-year citation counts (last 5 years)
- References (count)
-
73Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.Φ50 | 180 |
| abstract_inverted_index.(MPI) | 28 |
| abstract_inverted_index.Owing | 52 |
| abstract_inverted_index.SPION | 211, 272 |
| abstract_inverted_index.Using | 147 |
| abstract_inverted_index.about | 263 |
| abstract_inverted_index.after | 276 |
| abstract_inverted_index.axial | 219 |
| abstract_inverted_index.based | 115 |
| abstract_inverted_index.cells | 214 |
| abstract_inverted_index.close | 122, 196 |
| abstract_inverted_index.coils | 174 |
| abstract_inverted_index.could | 240, 287 |
| abstract_inverted_index.drugs | 46, 238 |
| abstract_inverted_index.field | 59, 109, 126 |
| abstract_inverted_index.found | 80 |
| abstract_inverted_index.i.e., | 30 |
| abstract_inverted_index.inner | 177, 229 |
| abstract_inverted_index.oxide | 36 |
| abstract_inverted_index.range | 261 |
| abstract_inverted_index.reach | 85 |
| abstract_inverted_index.rows, | 123 |
| abstract_inverted_index.size, | 57 |
| abstract_inverted_index.small | 18 |
| abstract_inverted_index.study | 131, 294 |
| abstract_inverted_index.this, | 100 |
| abstract_inverted_index.three | 169, 207 |
| abstract_inverted_index.tumor | 213 |
| abstract_inverted_index.types | 21, 208 |
| abstract_inverted_index.using | 280 |
| abstract_inverted_index.vitro | 107 |
| abstract_inverted_index.width | 188 |
| abstract_inverted_index.SPIONs | 157 |
| abstract_inverted_index.before | 274 |
| abstract_inverted_index.cancer | 16, 313 |
| abstract_inverted_index.during | 312 |
| abstract_inverted_index.field. | 146 |
| abstract_inverted_index.height | 183 |
| abstract_inverted_index.hollow | 117 |
| abstract_inverted_index.imaged | 279 |
| abstract_inverted_index.killed | 212 |
| abstract_inverted_index.local, | 300 |
| abstract_inverted_index.method | 102 |
| abstract_inverted_index.other. | 200 |
| abstract_inverted_index.rabbit | 161, 225 |
| abstract_inverted_index.radial | 182, 221 |
| abstract_inverted_index.rapid, | 301 |
| abstract_inverted_index.showed | 204 |
| abstract_inverted_index.state. | 292 |
| abstract_inverted_index.study, | 2 |
| abstract_inverted_index.system | 8, 154, 166, 285 |
| abstract_inverted_index.target | 253 |
| abstract_inverted_index.within | 227, 255 |
| abstract_inverted_index.SPIONs, | 96 |
| abstract_inverted_index.achieve | 99 |
| abstract_inverted_index.average | 87 |
| abstract_inverted_index.bladder | 15, 44, 162, 226 |
| abstract_inverted_index.coupled | 42 |
| abstract_inverted_index.further | 316 |
| abstract_inverted_index.future. | 326 |
| abstract_inverted_index.imaging | 27 |
| abstract_inverted_index.method, | 149 |
| abstract_inverted_index.minimal | 55 |
| abstract_inverted_index.motions | 244 |
| abstract_inverted_index.planned | 323 |
| abstract_inverted_index.precise | 303 |
| abstract_inverted_index.process | 311 |
| abstract_inverted_index.reflect | 289 |
| abstract_inverted_index.results | 203 |
| abstract_inverted_index.scheme. | 51 |
| abstract_inverted_index.single- | 31, 93 |
| abstract_inverted_index.undergo | 241 |
| abstract_inverted_index.animals. | 19 |
| abstract_inverted_index.arranged | 119, 173 |
| abstract_inverted_index.coupling | 50 |
| abstract_inverted_index.covalent | 49 |
| abstract_inverted_index.delivery | 7, 112, 153, 165, 233, 243, 277, 305 |
| abstract_inverted_index.diameter | 178 |
| abstract_inverted_index.gradient | 66, 75 |
| abstract_inverted_index.injected | 239 |
| abstract_inverted_index.location | 254 |
| abstract_inverted_index.magnetic | 25, 58, 108, 125, 145, 151, 237 |
| abstract_inverted_index.particle | 26, 56 |
| abstract_inverted_index.physical | 291 |
| abstract_inverted_index.research | 317 |
| abstract_inverted_index.selected | 40 |
| abstract_inverted_index.therapy, | 314 |
| abstract_inverted_index.therapy. | 163 |
| abstract_inverted_index.velocity | 88 |
| abstract_inverted_index.(SPIONs), | 38 |
| abstract_inverted_index.addition, | 270 |
| abstract_inverted_index.adjusting | 217 |
| abstract_inverted_index.coaxially | 120, 170 |
| abstract_inverted_index.consisted | 167 |
| abstract_inverted_index.delivered | 247 |
| abstract_inverted_index.developed | 10, 114, 159 |
| abstract_inverted_index.home-made | 282 |
| abstract_inverted_index.influence | 136 |
| abstract_inverted_index.necessary | 83 |
| abstract_inverted_index.open-bore | 283 |
| abstract_inverted_index.positions | 222 |
| abstract_inverted_index.proximity | 197 |
| abstract_inverted_index.specified | 252 |
| abstract_inverted_index.strengths | 60 |
| abstract_inverted_index.structure | 140 |
| abstract_inverted_index.treatment | 13 |
| abstract_inverted_index.aggregated | 249 |
| abstract_inverted_index.anti-tumor | 45 |
| abstract_inverted_index.multi-core | 33, 95 |
| abstract_inverted_index.parameters | 142 |
| abstract_inverted_index.positioned | 194 |
| abstract_inverted_index.simulation | 127 |
| abstract_inverted_index.structure, | 235 |
| abstract_inverted_index.technology | 321 |
| abstract_inverted_index.aggregation | 260 |
| abstract_inverted_index.capability, | 29 |
| abstract_inverted_index.contributes | 295 |
| abstract_inverted_index.development | 298 |
| abstract_inverted_index.multi-coils | 118 |
| abstract_inverted_index.preclinical | 12 |
| abstract_inverted_index.single-core | 156 |
| abstract_inverted_index.MPI/delivery | 319 |
| abstract_inverted_index.constructing | 104 |
| abstract_inverted_index.distribution | 273 |
| abstract_inverted_index.drug-coupled | 210 |
| abstract_inverted_index.effectively. | 215 |
| abstract_inverted_index.experimental | 202 |
| abstract_inverted_index.equidistantly | 172 |
| abstract_inverted_index.nanoparticles | 23, 37 |
| abstract_inverted_index.realistically | 288 |
| abstract_inverted_index.respectively. | 97 |
| abstract_inverted_index.visualization | 308 |
| abstract_inverted_index.high-efficiency | 4 |
| abstract_inverted_index.synchronization | 320 |
| abstract_inverted_index.two-dimensional | 242 |
| abstract_inverted_index.superparamagnetic | 5, 34 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 90 |
| corresponding_author_ids | https://openalex.org/A5100402925, https://openalex.org/A5112010316 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 14 |
| corresponding_institution_ids | https://openalex.org/I4210129955, https://openalex.org/I91656880 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8299999833106995 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.76595348 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |