Development of KISS1 knockout pigs is characterized by hypogonadotropic hypogonadism, normal growth, and reduced skatole Article Swipe
Daniel F Ahern
,
Kyra Martins
,
Julio M. Flórez
,
Caitlin E Ross
,
Abe Huisman
,
Robert A. Cushman
,
Sydney L Shuping
,
Casey C Nestor
,
Amy T Desaulniers
,
Brett R. White
,
Tad S. Sonstegard
,
C. A. Lents
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1093/biolre/ioae140
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1093/biolre/ioae140
Kisspeptin is a major regulator of gonadotropin secretion in pigs. Previously, CRISPR/Cas9 knockout of KISS1 was used to develop a mosaic parental line of pigs to generate offspring that would not need castration due to loss of kisspeptin. The current goal was to characterize growth and reproductive development of F1 pigs from this parental line. Body weights, gonadotropin concentrations and gonadal development were measured from birth through development (boars to 220 days of age, n = 42; gilts to 160 days of age, n = 36). Testosterone, skatole, and androstenone were also measured in boars. Blood samples were collected by jugular venipuncture for quantification of serum hormones, gonadal tissues were collected for gross morphology and histology, and a fat biopsy was collected (boars) for skatole and androstenone analysis. Body weight did not differ with genotype. There were no differences between KISS1+/+ and heterozygote KISS1+/− animals for most parameters measured. Gonadotropin concentrations were reduced in KISS1−/− boars and gilts compared with KISS1+/+ and KISS1+/− animals (P < 0.05). Concentrations of testosterone in serum and both androstenone and skatole in adipose were less in KISS1−/− boars than in KISS1+/+ and KISS1+/− boars (P < 0.05). Hypogonadism was present in all KISS1−/− gilts and boars. These data indicate that knocking out KISS1 causes hypogonadotropic hypogonadism but does not negatively affect growth in pigs. Only one KISS1 allele is needed for normal gonadotropin secretion and gonadal development, and accumulation of compounds in adipose leading to boar taint.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/biolre/ioae140
- https://academic.oup.com/biolreprod/advance-article-pdf/doi/10.1093/biolre/ioae140/59634130/ioae140.pdf
- OA Status
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4403174123Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/biolre/ioae140Digital Object Identifier
- Title
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Development of KISS1 knockout pigs is characterized by hypogonadotropic hypogonadism, normal growth, and reduced skatoleWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-10-07Full publication date if available
- Authors
-
Daniel F Ahern, Kyra Martins, Julio M. Flórez, Caitlin E Ross, Abe Huisman, Robert A. Cushman, Sydney L Shuping, Casey C Nestor, Amy T Desaulniers, Brett R. White, Tad S. Sonstegard, C. A. LentsList of authors in order
- Landing page
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https://doi.org/10.1093/biolre/ioae140Publisher landing page
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https://academic.oup.com/biolreprod/advance-article-pdf/doi/10.1093/biolre/ioae140/59634130/ioae140.pdfDirect link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://academic.oup.com/biolreprod/advance-article-pdf/doi/10.1093/biolre/ioae140/59634130/ioae140.pdfDirect OA link when available
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Androstenone, Kisspeptin, Endocrinology, Biology, Skatole, Internal medicine, Ovulation, Adipose tissue, Gonadotropin, Testosterone (patch), Hormone, Medicine, Biochemistry, Indole testTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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70Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.serum | 106, 172 |
| abstract_inverted_index.would | 30 |
| abstract_inverted_index.(boars | 69 |
| abstract_inverted_index.0.05). | 167, 193 |
| abstract_inverted_index.affect | 217 |
| abstract_inverted_index.allele | 224 |
| abstract_inverted_index.biopsy | 120 |
| abstract_inverted_index.boars. | 95, 202 |
| abstract_inverted_index.causes | 210 |
| abstract_inverted_index.differ | 133 |
| abstract_inverted_index.growth | 45, 218 |
| abstract_inverted_index.mosaic | 21 |
| abstract_inverted_index.needed | 226 |
| abstract_inverted_index.normal | 228 |
| abstract_inverted_index.taint. | 243 |
| abstract_inverted_index.weight | 130 |
| abstract_inverted_index.(boars) | 123 |
| abstract_inverted_index.adipose | 179, 239 |
| abstract_inverted_index.animals | 145, 164 |
| abstract_inverted_index.between | 140 |
| abstract_inverted_index.current | 40 |
| abstract_inverted_index.develop | 19 |
| abstract_inverted_index.gonadal | 61, 108, 232 |
| abstract_inverted_index.jugular | 101 |
| abstract_inverted_index.leading | 240 |
| abstract_inverted_index.present | 196 |
| abstract_inverted_index.reduced | 153 |
| abstract_inverted_index.samples | 97 |
| abstract_inverted_index.skatole | 125, 177 |
| abstract_inverted_index.through | 67 |
| abstract_inverted_index.tissues | 109 |
| abstract_inverted_index.&lt; | 166, 192 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.KISS1+/+ | 141, 161, 187 |
| abstract_inverted_index.compared | 159 |
| abstract_inverted_index.generate | 27 |
| abstract_inverted_index.indicate | 205 |
| abstract_inverted_index.knocking | 207 |
| abstract_inverted_index.knockout | 13 |
| abstract_inverted_index.measured | 64, 93 |
| abstract_inverted_index.parental | 22, 54 |
| abstract_inverted_index.skatole, | 88 |
| abstract_inverted_index.weights, | 57 |
| abstract_inverted_index.analysis. | 128 |
| abstract_inverted_index.collected | 99, 111, 122 |
| abstract_inverted_index.compounds | 237 |
| abstract_inverted_index.genotype. | 135 |
| abstract_inverted_index.hormones, | 107 |
| abstract_inverted_index.measured. | 149 |
| abstract_inverted_index.offspring | 28 |
| abstract_inverted_index.regulator | 5 |
| abstract_inverted_index.secretion | 8, 230 |
| abstract_inverted_index.KISS1+/− | 144, 163, 189 |
| abstract_inverted_index.Kisspeptin | 1 |
| abstract_inverted_index.castration | 33 |
| abstract_inverted_index.histology, | 116 |
| abstract_inverted_index.morphology | 114 |
| abstract_inverted_index.negatively | 216 |
| abstract_inverted_index.parameters | 148 |
| abstract_inverted_index.CRISPR/Cas9 | 12 |
| abstract_inverted_index.Previously, | 11 |
| abstract_inverted_index.development | 48, 62, 68 |
| abstract_inverted_index.differences | 139 |
| abstract_inverted_index.kisspeptin. | 38 |
| abstract_inverted_index.Gonadotropin | 150 |
| abstract_inverted_index.Hypogonadism | 194 |
| abstract_inverted_index.KISS1−/− | 155, 183, 199 |
| abstract_inverted_index.accumulation | 235 |
| abstract_inverted_index.androstenone | 90, 127, 175 |
| abstract_inverted_index.characterize | 44 |
| abstract_inverted_index.development, | 233 |
| abstract_inverted_index.gonadotropin | 7, 58, 229 |
| abstract_inverted_index.heterozygote | 143 |
| abstract_inverted_index.hypogonadism | 212 |
| abstract_inverted_index.reproductive | 47 |
| abstract_inverted_index.testosterone | 170 |
| abstract_inverted_index.venipuncture | 102 |
| abstract_inverted_index.Testosterone, | 87 |
| abstract_inverted_index.Concentrations | 168 |
| abstract_inverted_index.concentrations | 59, 151 |
| abstract_inverted_index.quantification | 104 |
| abstract_inverted_index.hypogonadotropic | 211 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 91 |
| countries_distinct_count | 3 |
| institutions_distinct_count | 12 |
| citation_normalized_percentile.value | 0.73386772 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |