Development of neutralizing antibodies against SARS-CoV-2, using a high-throughput single-B-cell cloning method Article Swipe
Yang Dou
,
Ke Xu
,
Yong‐Qiang Deng
,
Zijing Jia
,
Jun Lan
,
Xiaoyu Xu
,
Guorui Zhang
,
Tian-Shu Cao
,
Pan Liu
,
Xiangxi Wang
,
Xinquan Wang
,
Lingjie Xu
,
Pan Du
,
Cheng‐Feng Qin
,
Hong Liu
,
Yafeng Li
,
Guizhen Wu
,
Kang Wang
,
Lu Bai
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1093/abt/tbad002
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1093/abt/tbad002
Background Rapid and efficient strategies are needed to discover neutralizing antibodies (nAbs) from B cells derived from virus-infected patients. Methods Here, we report a high-throughput single-B-cell cloning method for high-throughput isolation of nAbs targeting diverse epitopes on the SARS-CoV-2-RBD (receptor binding domain) from convalescent COVID-19 patients. This method is simple, fast and highly efficient in generating SARS-CoV-2-neutralizing antibodies from COVID-19 patients’ B cells. Results Using this method, we have developed multiple nAbs against distinct SARS-CoV-2-RBD epitopes. CryoEM and crystallography revealed precisely how they bind RBD. In live virus assay, these nAbs are effective in blocking viral entry to the host cells. Conclusion This simple and efficient method may be useful in developing human therapeutic antibodies for other diseases and next pandemic.
Related Topics
Concepts
Epitope
Virology
Antibody
Cloning (programming)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Virus
Biology
Pandemic
Computational biology
Coronavirus disease 2019 (COVID-19)
Medicine
Immunology
Computer science
Infectious disease (medical specialty)
Programming language
Pathology
Disease
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/abt/tbad002
- https://academic.oup.com/abt/advance-article-pdf/doi/10.1093/abt/tbad002/49501404/tbad002.pdf
- OA Status
- gold
- Cited By
- 3
- References
- 46
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4321215975
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4321215975Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/abt/tbad002Digital Object Identifier
- Title
-
Development of neutralizing antibodies against SARS-CoV-2, using a high-throughput single-B-cell cloning methodWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-02-17Full publication date if available
- Authors
-
Yang Dou, Ke Xu, Yong‐Qiang Deng, Zijing Jia, Jun Lan, Xiaoyu Xu, Guorui Zhang, Tian-Shu Cao, Pan Liu, Xiangxi Wang, Xinquan Wang, Lingjie Xu, Pan Du, Cheng‐Feng Qin, Hong Liu, Yafeng Li, Guizhen Wu, Kang Wang, Lu BaiList of authors in order
- Landing page
-
https://doi.org/10.1093/abt/tbad002Publisher landing page
- PDF URL
-
https://academic.oup.com/abt/advance-article-pdf/doi/10.1093/abt/tbad002/49501404/tbad002.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://academic.oup.com/abt/advance-article-pdf/doi/10.1093/abt/tbad002/49501404/tbad002.pdfDirect OA link when available
- Concepts
-
Epitope, Virology, Antibody, Cloning (programming), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Virus, Biology, Pandemic, Computational biology, Coronavirus disease 2019 (COVID-19), Medicine, Immunology, Computer science, Infectious disease (medical specialty), Programming language, Pathology, DiseaseTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 2, 2023: 1Per-year citation counts (last 5 years)
- References (count)
-
46Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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