Development of platelet replacement therapy using human induced pluripotent stem cells Article Swipe
Sou Nakamura
,
Naoshi Sugimoto
,
Koji Eto
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1111/dgd.12711
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1111/dgd.12711
In the body, platelets mainly work as a hemostatic agent, and the lack of platelets can cause serious bleeding. Induced pluripotent stem (iPS) cells potentially allow for a stable supply of platelets that are independent of donors and eliminate the risk of infection. However, a major challenge in iPS cell‐based systems is producing the number of platelets required for a single transfusion (more than 200 billion in Japan). Thus, development in large‐scale culturing technology is required. In previous studies, we generated a self‐renewable, immortalized megakaryocyte cell line by transfecting iPS cell‐derived hematopoietic progenitor cells with c‐MYC, BMI1, and BCL‐XL genes. Optimization of the culture conditions, including the discovery of a novel fluid‐physical factor, turbulence, in the production of platelets in vivo, and the development of bioreactors that apply turbulence have enabled us to generate platelets of clinical quality and quantity. We have further generated platelets deleted of HLA class I expression by using genetic modification technology for patients suffering from alloimmune transfusion refractoriness, since these patients are underserved by current blood donation systems. In this review, we highlight current research and our recent work on iPS cell‐derived platelet induction.
Related Topics
Concepts
Induced pluripotent stem cell
Platelet
Haematopoiesis
Biology
Stem cell
Progenitor cell
Platelet transfusion
Genetic enhancement
Immunology
Cell biology
Gene
Genetics
Embryonic stem cell
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1111/dgd.12711
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/dgd.12711
- OA Status
- hybrid
- Cited By
- 7
- References
- 83
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3124612683
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3124612683Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1111/dgd.12711Digital Object Identifier
- Title
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Development of platelet replacement therapy using human induced pluripotent stem cellsWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-01-29Full publication date if available
- Authors
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Sou Nakamura, Naoshi Sugimoto, Koji EtoList of authors in order
- Landing page
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https://doi.org/10.1111/dgd.12711Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/dgd.12711Direct link to full text PDF
- Open access
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/dgd.12711Direct OA link when available
- Concepts
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Induced pluripotent stem cell, Platelet, Haematopoiesis, Biology, Stem cell, Progenitor cell, Platelet transfusion, Genetic enhancement, Immunology, Cell biology, Gene, Genetics, Embryonic stem cellTop concepts (fields/topics) attached by OpenAlex
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7Total citation count in OpenAlex
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2025: 1, 2024: 1, 2023: 2, 2022: 1, 2021: 2Per-year citation counts (last 5 years)
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83Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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