Development of polycarbonate urethane‐based materials with controlled diclofenac release for cartilage replacement Article Swipe
Andréia Sofia Oliveira
,
Inês C. Ferreira
,
A.C. Branco
,
João C. Silva
,
Carolina Marto-Costa
,
Pedro Nolasco
,
Ana C. Marques
,
Diana Silva
,
R. Colaço
,
C.G. Figueiredo-Pina
,
Ana Paula Serro
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1002/jbm.b.35042
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1002/jbm.b.35042
Hydrogels are very promising human cartilage replacement materials since they are able to mimic its structure and properties. Besides, they can be used as platforms for drug delivery to reduce inflammatory postsurgical reactions. Polycarbonate urethane (PCU) has been used in orthopedic applications due to its long‐term biocompatibility and bio‐durability. In this work, PCU‐based hydrogels with the ability to release an anti‐inflammatory (diclofenac) were developed, for the first time, for such purpose. The materials were reinforced with different amounts of cellulose acetate (CA, 10%, 15%, and 25% w/w) or carbon nanotubes (CNT, 1% and 2% w/w) in order to improve their mechanical properties. Samples were characterized in terms of compressive and tensile mechanical behavior. It was found that 15% CA and 2% CNT reinforcement led to the best mechanical properties. Thus, these materials were further characterized in terms of morphology, wettability, and friction coefficient (CoF). Contrarily to CNTs, the addition of CA significantly increased the material's porosity. Both materials became more hydrophilic, and the CoF slightly increased for PCU + 15%CA. The materials were loaded by soaking with diclofenac, and drug release experiments were conducted. PCU, PCU + 15%CA and PCU + 2%CNT presented similar release profiles, being able to ensure a controlled release of DFN for at least 4 days. Finally , in vitro cytotoxicity tests using human chondrocytes were also performed and confirmed a high biocompatibility for the three studied materials.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/jbm.b.35042
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbm.b.35042
- OA Status
- bronze
- Cited By
- 6
- References
- 87
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4214729215
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4214729215Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/jbm.b.35042Digital Object Identifier
- Title
-
Development of polycarbonate urethane‐based materials with controlled diclofenac release for cartilage replacementWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-02-28Full publication date if available
- Authors
-
Andréia Sofia Oliveira, Inês C. Ferreira, A.C. Branco, João C. Silva, Carolina Marto-Costa, Pedro Nolasco, Ana C. Marques, Diana Silva, R. Colaço, C.G. Figueiredo-Pina, Ana Paula SerroList of authors in order
- Landing page
-
https://doi.org/10.1002/jbm.b.35042Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbm.b.35042Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbm.b.35042Direct OA link when available
- Concepts
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Materials science, Biocompatibility, Composite material, Compressive strength, Self-healing hydrogels, Ultimate tensile strength, Drug delivery, Swelling, Biomedical engineering, Polymer, Porosity, Chemical engineering, Nanotechnology, Polymer chemistry, Engineering, Metallurgy, MedicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
6Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 4, 2024: 1, 2022: 1Per-year citation counts (last 5 years)
- References (count)
-
87Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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