Development of suitable working Protocol for in vitro Tape Stripping: A Case Study with biocompatible Aceclofenac-loaded topical Nanoemulsions Article Swipe
Jela Milić
,
Sanela Savić
,
Ivana Pantelić
,
Bojan Marković
,
Snežana Savić
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.24355/dbbs.084-202001221146-0
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.24355/dbbs.084-202001221146-0
Considering the numerous organizational and legislative issues associated with in vivo studies, the present study aimed \nto develop in vitro tape stripping protocol that could serve as a prospective technique for skin penetration studies. The \nresearch was mainly focused on the suitability of transepidermal water loss (TEWL) measurements, as a barrier \nintegrity test for porcine ear skin subjected to freezing/thawing procedure, as well as on the selection of the most \nsuitable device for pressing adhesive tapes onto the porcine ear surface during skin stripping procedure. Obtained \nresults suggest that TEWL measurements were able to detect the damage of the stratum corneum (SC) caused by \nphysical impairment (using adhesive tapes) and tissue degradation/dehydration (prolonged storage at –20ºC/ambient \nconditions). Penetration profiles of aceclofenac from nanoemulsions based on sucrose esters or polysorbate 80 as \ncoemulsifiers, obtained in vitro (using a roller as pressure device), were in a good agreement with data obtained in vivo \non humans, supporting the use of developed in vitro tape-stripping protocol in skin formulation development and \noptimization.
Related Topics
Concepts
Stratum corneum
Transepidermal water loss
Biomedical engineering
Aceclofenac
Adhesive
Penetration (warfare)
Materials science
In vivo
Stripping (fiber)
Chromatography
Chemistry
Nanotechnology
Composite material
Medicine
Pathology
Layer (electronics)
Biotechnology
Biology
Operations research
Engineering
Metadata
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- article
- Language
- en
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- OA Status
- green
- Cited By
- 2
- Related Works
- 20
- OpenAlex ID
- https://openalex.org/W3004998670
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3004998670Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.24355/dbbs.084-202001221146-0Digital Object Identifier
- Title
-
Development of suitable working Protocol for in vitro Tape Stripping: A Case Study with biocompatible Aceclofenac-loaded topical NanoemulsionsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-01-01Full publication date if available
- Authors
-
Jela Milić, Sanela Savić, Ivana Pantelić, Bojan Marković, Snežana SavićList of authors in order
- Landing page
-
https://publikationsserver.tu-braunschweig.de/receive/dbbs_mods_00068178Publisher landing page
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https://publikationsserver.tu-braunschweig.de/servlets/MCRFileNodeServlet/dbbs_derivate_00046871/Ilic_Savic_et_al_Development_of_suitable_working%20Protocol.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
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https://publikationsserver.tu-braunschweig.de/servlets/MCRFileNodeServlet/dbbs_derivate_00046871/Ilic_Savic_et_al_Development_of_suitable_working%20Protocol.pdfDirect OA link when available
- Concepts
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Stratum corneum, Transepidermal water loss, Biomedical engineering, Aceclofenac, Adhesive, Penetration (warfare), Materials science, In vivo, Stripping (fiber), Chromatography, Chemistry, Nanotechnology, Composite material, Medicine, Pathology, Layer (electronics), Biotechnology, Biology, Operations research, EngineeringTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2023: 1Per-year citation counts (last 5 years)
- Related works (count)
-
20Other works algorithmically related by OpenAlex
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