Developmental loss of MeCP2 from VIP interneurons impairs cortical function and behavior Article Swipe
James M. Mossner
,
Renata Batista‐Brito
,
Rima Pant
,
Jessica A. Cardin
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.7554/elife.55639
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.7554/elife.55639
Rett Syndrome is a devastating neurodevelopmental disorder resulting from mutations in the gene MECP2. Mutations of Mecp2 that are restricted to GABAergic cell types largely replicate the behavioral phenotypes associated with mouse models of Rett Syndrome, suggesting a pathophysiological role for inhibitory interneurons. Recent work has suggested that vasoactive intestinal peptide-expressing (VIP) interneurons may play a critical role in the proper development and function of cortical circuits, making them a potential key point of vulnerability in neurodevelopmental disorders. However, little is known about the role of VIP interneurons in Rett Syndrome. Here we find that loss of MeCP2 specifically from VIP interneurons replicates key neural and behavioral phenotypes observed following global Mecp2 loss of function.
Related Topics
Concepts
Rett syndrome
MECP2
Neuroscience
Vasoactive intestinal peptide
Neurodevelopmental disorder
GABAergic
Biology
Autism
Phenotype
Loss function
Interneuron
Inhibitory postsynaptic potential
Psychology
Gene
Neuropeptide
Genetics
Developmental psychology
Receptor
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.7554/elife.55639
- OA Status
- gold
- Cited By
- 56
- References
- 53
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3020594651
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W3020594651Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.7554/elife.55639Digital Object Identifier
- Title
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Developmental loss of MeCP2 from VIP interneurons impairs cortical function and behaviorWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-04-28Full publication date if available
- Authors
-
James M. Mossner, Renata Batista‐Brito, Rima Pant, Jessica A. CardinList of authors in order
- Landing page
-
https://doi.org/10.7554/elife.55639Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.7554/elife.55639Direct OA link when available
- Concepts
-
Rett syndrome, MECP2, Neuroscience, Vasoactive intestinal peptide, Neurodevelopmental disorder, GABAergic, Biology, Autism, Phenotype, Loss function, Interneuron, Inhibitory postsynaptic potential, Psychology, Gene, Neuropeptide, Genetics, Developmental psychology, ReceptorTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
56Total citation count in OpenAlex
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2025: 11, 2024: 5, 2023: 15, 2022: 10, 2021: 10Per-year citation counts (last 5 years)
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53Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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