Dexamethasone Alters Tracheal Aspirate T-Cell Cytokine Production in Ventilated Preterm Infants Article Swipe
Siamak Yazdi
,
Ekta Patel
,
Colby D. Richardson
,
Karen Hardy
,
John E. Baatz
,
Jennifer K. Mulligan
,
Rita M. Ryan
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/children8100879
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/children8100879
Postnatal corticosteroids improve respiratory status and facilitate respiratory support weaning in preterm infants with bronchopulmonary dysplasia (BPD). Older literature describes characteristic cytokine profiles in tracheal aspirates (TA) of BPD patients which are altered with corticosteroids. Corticosteroids also influence peripheral blood T-cell presence. However, little is known regarding TA T-cell phenotype and cytokine production before or after exogenous corticosteroids. We hypothesized that postnatal dexamethasone alters the TA T-cell cytokine profiles of preterm infants. TA samples were collected from 14 infants born from 23 0/7 to 28 6/7 weeks who were mechanically ventilated for at least 14 days. Samples were collected up to 72 h before a ten-day dexamethasone course and again 1 to 3 calendar days after dexamethasone initiation. The primary outcome was change in T cell populations present in TA and their intracellular cytokine profile after dexamethasone treatment, ascertained via flow cytometry. Following dexamethasone treatment, there were significant decreases in respiratory severity score (RSS), percent CD4+IL-6+ cells, CD8+IL-6+ cells, CXCR3+IL-6+ cells, and CXCR3+IL-2+ cells and total intracellular IFN-γ in TA. RSS significantly correlated with TA percent CD4+IL-6+ cells. To our knowledge, this is the first study demonstrating that dexamethasone reduced T-cell IL-6 and this reduction was associated with improved RSS in pre-term infants with evolving BPD.
Related Topics
Concepts
Dexamethasone
Medicine
Bronchopulmonary dysplasia
Cytokine
Weaning
Internal medicine
Immunology
Endocrinology
Andrology
Biology
Gestational age
Pregnancy
Genetics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/children8100879
- https://www.mdpi.com/2227-9067/8/10/879/pdf?version=1633162255
- OA Status
- gold
- Cited By
- 3
- References
- 34
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3207044153
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3207044153Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/children8100879Digital Object Identifier
- Title
-
Dexamethasone Alters Tracheal Aspirate T-Cell Cytokine Production in Ventilated Preterm InfantsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-10-02Full publication date if available
- Authors
-
Siamak Yazdi, Ekta Patel, Colby D. Richardson, Karen Hardy, John E. Baatz, Jennifer K. Mulligan, Rita M. RyanList of authors in order
- Landing page
-
https://doi.org/10.3390/children8100879Publisher landing page
- PDF URL
-
https://www.mdpi.com/2227-9067/8/10/879/pdf?version=1633162255Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2227-9067/8/10/879/pdf?version=1633162255Direct OA link when available
- Concepts
-
Dexamethasone, Medicine, Bronchopulmonary dysplasia, Cytokine, Weaning, Internal medicine, Immunology, Endocrinology, Andrology, Biology, Gestational age, Pregnancy, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2023: 2, 2022: 1Per-year citation counts (last 5 years)
- References (count)
-
34Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3207044153 |
|---|---|
| doi | https://doi.org/10.3390/children8100879 |
| ids.doi | https://doi.org/10.3390/children8100879 |
| ids.mag | 3207044153 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/34682144 |
| ids.openalex | https://openalex.org/W3207044153 |
| fwci | 0.53061972 |
| type | article |
| title | Dexamethasone Alters Tracheal Aspirate T-Cell Cytokine Production in Ventilated Preterm Infants |
| awards[0].id | https://openalex.org/G5338552414 |
| awards[0].funder_id | https://openalex.org/F4320332161 |
| awards[0].display_name | |
| awards[0].funder_award_id | R01AI34698 |
| awards[0].funder_display_name | National Institutes of Health |
| biblio.issue | 10 |
| biblio.volume | 8 |
| biblio.last_page | 879 |
| biblio.first_page | 879 |
| topics[0].id | https://openalex.org/T10549 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2740 |
| topics[0].subfield.display_name | Pulmonary and Respiratory Medicine |
| topics[0].display_name | Neonatal Respiratory Health Research |
| topics[1].id | https://openalex.org/T10322 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9984999895095825 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2740 |
| topics[1].subfield.display_name | Pulmonary and Respiratory Medicine |
| topics[1].display_name | Respiratory Support and Mechanisms |
| topics[2].id | https://openalex.org/T11586 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9957000017166138 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2746 |
| topics[2].subfield.display_name | Surgery |
| topics[2].display_name | Congenital Diaphragmatic Hernia Studies |
| funders[0].id | https://openalex.org/F4320332161 |
| funders[0].ror | https://ror.org/01cwqze88 |
| funders[0].display_name | National Institutes of Health |
| is_xpac | False |
| apc_list.value | 1800 |
| apc_list.currency | CHF |
| apc_list.value_usd | 1949 |
| apc_paid.value | 1800 |
| apc_paid.currency | CHF |
| apc_paid.value_usd | 1949 |
| concepts[0].id | https://openalex.org/C2780401358 |
| concepts[0].level | 2 |
| concepts[0].score | 0.8172765970230103 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q422252 |
| concepts[0].display_name | Dexamethasone |
| concepts[1].id | https://openalex.org/C71924100 |
| concepts[1].level | 0 |
| concepts[1].score | 0.6807416081428528 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[1].display_name | Medicine |
| concepts[2].id | https://openalex.org/C2778721537 |
| concepts[2].level | 4 |
| concepts[2].score | 0.6679089665412903 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q922640 |
| concepts[2].display_name | Bronchopulmonary dysplasia |
| concepts[3].id | https://openalex.org/C2778690821 |
| concepts[3].level | 2 |
| concepts[3].score | 0.6562715768814087 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q212354 |
| concepts[3].display_name | Cytokine |
| concepts[4].id | https://openalex.org/C2780655333 |
| concepts[4].level | 2 |
| concepts[4].score | 0.4948274493217468 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q333203 |
| concepts[4].display_name | Weaning |
| concepts[5].id | https://openalex.org/C126322002 |
| concepts[5].level | 1 |
| concepts[5].score | 0.4044520854949951 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[5].display_name | Internal medicine |
| concepts[6].id | https://openalex.org/C203014093 |
| concepts[6].level | 1 |
| concepts[6].score | 0.3802133798599243 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[6].display_name | Immunology |
| concepts[7].id | https://openalex.org/C134018914 |
| concepts[7].level | 1 |
| concepts[7].score | 0.34278613328933716 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q162606 |
| concepts[7].display_name | Endocrinology |
| concepts[8].id | https://openalex.org/C16685009 |
| concepts[8].level | 1 |
| concepts[8].score | 0.32702574133872986 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q335057 |
| concepts[8].display_name | Andrology |
| concepts[9].id | https://openalex.org/C86803240 |
| concepts[9].level | 0 |
| concepts[9].score | 0.16008463501930237 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[9].display_name | Biology |
| concepts[10].id | https://openalex.org/C2778376644 |
| concepts[10].level | 3 |
| concepts[10].score | 0.13436293601989746 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q2253111 |
| concepts[10].display_name | Gestational age |
| concepts[11].id | https://openalex.org/C2779234561 |
| concepts[11].level | 2 |
| concepts[11].score | 0.0 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q11995 |
| concepts[11].display_name | Pregnancy |
| concepts[12].id | https://openalex.org/C54355233 |
| concepts[12].level | 1 |
| concepts[12].score | 0.0 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[12].display_name | Genetics |
| keywords[0].id | https://openalex.org/keywords/dexamethasone |
| keywords[0].score | 0.8172765970230103 |
| keywords[0].display_name | Dexamethasone |
| keywords[1].id | https://openalex.org/keywords/medicine |
| keywords[1].score | 0.6807416081428528 |
| keywords[1].display_name | Medicine |
| keywords[2].id | https://openalex.org/keywords/bronchopulmonary-dysplasia |
| keywords[2].score | 0.6679089665412903 |
| keywords[2].display_name | Bronchopulmonary dysplasia |
| keywords[3].id | https://openalex.org/keywords/cytokine |
| keywords[3].score | 0.6562715768814087 |
| keywords[3].display_name | Cytokine |
| keywords[4].id | https://openalex.org/keywords/weaning |
| keywords[4].score | 0.4948274493217468 |
| keywords[4].display_name | Weaning |
| keywords[5].id | https://openalex.org/keywords/internal-medicine |
| keywords[5].score | 0.4044520854949951 |
| keywords[5].display_name | Internal medicine |
| keywords[6].id | https://openalex.org/keywords/immunology |
| keywords[6].score | 0.3802133798599243 |
| keywords[6].display_name | Immunology |
| keywords[7].id | https://openalex.org/keywords/endocrinology |
| keywords[7].score | 0.34278613328933716 |
| keywords[7].display_name | Endocrinology |
| keywords[8].id | https://openalex.org/keywords/andrology |
| keywords[8].score | 0.32702574133872986 |
| keywords[8].display_name | Andrology |
| keywords[9].id | https://openalex.org/keywords/biology |
| keywords[9].score | 0.16008463501930237 |
| keywords[9].display_name | Biology |
| keywords[10].id | https://openalex.org/keywords/gestational-age |
| keywords[10].score | 0.13436293601989746 |
| keywords[10].display_name | Gestational age |
| language | en |
| locations[0].id | doi:10.3390/children8100879 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S2736895435 |
| locations[0].source.issn | 2227-9067 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2227-9067 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Children |
| locations[0].source.host_organization | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.mdpi.com/2227-9067/8/10/879/pdf?version=1633162255 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Children |
| locations[0].landing_page_url | https://doi.org/10.3390/children8100879 |
| locations[1].id | pmid:34682144 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Children (Basel, Switzerland) |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/34682144 |
| locations[2].id | pmh:oai:doaj.org/article:1365f4af3a1a43368a0e9501bf8019d4 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306401280 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[2].source.host_organization | |
| locations[2].source.host_organization_name | |
| locations[2].license | cc-by-sa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | article |
| locations[2].license_id | https://openalex.org/licenses/cc-by-sa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Children, Vol 8, Iss 10, p 879 (2021) |
| locations[2].landing_page_url | https://doaj.org/article/1365f4af3a1a43368a0e9501bf8019d4 |
| locations[3].id | pmh:oai:mdpi.com:/2227-9067/8/10/879/ |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S4306400947 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | True |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | MDPI (MDPI AG) |
| locations[3].source.host_organization | https://openalex.org/I4210097602 |
| locations[3].source.host_organization_name | Multidisciplinary Digital Publishing Institute (Switzerland) |
| locations[3].source.host_organization_lineage | https://openalex.org/I4210097602 |
| locations[3].license | cc-by |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/cc-by |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Children; Volume 8; Issue 10; Pages: 879 |
| locations[3].landing_page_url | https://dx.doi.org/10.3390/children8100879 |
| locations[4].id | pmh:oai:pubmedcentral.nih.gov:8535110 |
| locations[4].is_oa | True |
| locations[4].source.id | https://openalex.org/S2764455111 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | PubMed Central |
| locations[4].source.host_organization | https://openalex.org/I1299303238 |
| locations[4].source.host_organization_name | National Institutes of Health |
| locations[4].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[4].license | other-oa |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | Text |
| locations[4].license_id | https://openalex.org/licenses/other-oa |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | Children (Basel) |
| locations[4].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/8535110 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5008202435 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Siamak Yazdi |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I153297377 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Pediatrics-Neonatology, Medical University of South Carolina, Charleston, SC 29425, USA |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I32389192 |
| authorships[0].affiliations[1].raw_affiliation_string | Department of Pediatrics-Neonatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA |
| authorships[0].institutions[0].id | https://openalex.org/I153297377 |
| authorships[0].institutions[0].ror | https://ror.org/012jban78 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I153297377 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | Medical University of South Carolina |
| authorships[0].institutions[1].id | https://openalex.org/I32389192 |
| authorships[0].institutions[1].ror | https://ror.org/008s83205 |
| authorships[0].institutions[1].type | education |
| authorships[0].institutions[1].lineage | https://openalex.org/I32389192 |
| authorships[0].institutions[1].country_code | US |
| authorships[0].institutions[1].display_name | University of Alabama at Birmingham |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Siamak M. Yazdi |
| authorships[0].is_corresponding | True |
| authorships[0].raw_affiliation_strings | Department of Pediatrics-Neonatology, Medical University of South Carolina, Charleston, SC 29425, USA, Department of Pediatrics-Neonatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA |
| authorships[1].author.id | https://openalex.org/A5058156956 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-3301-5167 |
| authorships[1].author.display_name | Ekta Patel |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I75421653 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Pediatrics-Neonatology, University of Missouri-Kansas City School of Medicine, Kansas City, MO 64108, USA |
| authorships[1].affiliations[1].institution_ids | https://openalex.org/I153297377 |
| authorships[1].affiliations[1].raw_affiliation_string | Department of Pediatrics-Neonatology, Medical University of South Carolina, Charleston, SC 29425, USA |
| authorships[1].institutions[0].id | https://openalex.org/I153297377 |
| authorships[1].institutions[0].ror | https://ror.org/012jban78 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I153297377 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | Medical University of South Carolina |
| authorships[1].institutions[1].id | https://openalex.org/I75421653 |
| authorships[1].institutions[1].ror | https://ror.org/01w0d5g70 |
| authorships[1].institutions[1].type | education |
| authorships[1].institutions[1].lineage | https://openalex.org/I75421653 |
| authorships[1].institutions[1].country_code | US |
| authorships[1].institutions[1].display_name | University of Missouri–Kansas City |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Ekta U. Patel |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Pediatrics-Neonatology, Medical University of South Carolina, Charleston, SC 29425, USA, Department of Pediatrics-Neonatology, University of Missouri-Kansas City School of Medicine, Kansas City, MO 64108, USA |
| authorships[2].author.id | https://openalex.org/A5075122283 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Colby D. Richardson |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I28792581 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Pediatrics-Neonatology, University of Rochester Medical Center, Rochester, NY 14642, USA |
| authorships[2].institutions[0].id | https://openalex.org/I28792581 |
| authorships[2].institutions[0].ror | https://ror.org/00trqv719 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I28792581, https://openalex.org/I5388228 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | University of Rochester Medical Center |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Colby D. Richardson |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Pediatrics-Neonatology, University of Rochester Medical Center, Rochester, NY 14642, USA |
| authorships[3].author.id | https://openalex.org/A5045717611 |
| authorships[3].author.orcid | https://orcid.org/0000-0003-1127-2397 |
| authorships[3].author.display_name | Karen Hardy |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I153297377 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Pediatrics-Neonatology, Medical University of South Carolina, Charleston, SC 29425, USA |
| authorships[3].institutions[0].id | https://openalex.org/I153297377 |
| authorships[3].institutions[0].ror | https://ror.org/012jban78 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I153297377 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | Medical University of South Carolina |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | K. Thomas Hardy |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Pediatrics-Neonatology, Medical University of South Carolina, Charleston, SC 29425, USA |
| authorships[4].author.id | https://openalex.org/A5002344510 |
| authorships[4].author.orcid | https://orcid.org/0000-0001-5870-1000 |
| authorships[4].author.display_name | John E. Baatz |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I153297377 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Pediatrics-Neonatology, Medical University of South Carolina, Charleston, SC 29425, USA |
| authorships[4].institutions[0].id | https://openalex.org/I153297377 |
| authorships[4].institutions[0].ror | https://ror.org/012jban78 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I153297377 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | Medical University of South Carolina |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | John E. Baatz |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Pediatrics-Neonatology, Medical University of South Carolina, Charleston, SC 29425, USA |
| authorships[5].author.id | https://openalex.org/A5057186355 |
| authorships[5].author.orcid | https://orcid.org/0000-0001-6880-6092 |
| authorships[5].author.display_name | Jennifer K. Mulligan |
| authorships[5].countries | US |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I33213144 |
| authorships[5].affiliations[0].raw_affiliation_string | Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida Gainesville, Gainesville, FL 32611, USA |
| authorships[5].affiliations[1].institution_ids | https://openalex.org/I153297377 |
| authorships[5].affiliations[1].raw_affiliation_string | Department of Otolaryngology, Medical University of South Carolina, Charleston, SC 29425, USA |
| authorships[5].institutions[0].id | https://openalex.org/I153297377 |
| authorships[5].institutions[0].ror | https://ror.org/012jban78 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I153297377 |
| authorships[5].institutions[0].country_code | US |
| authorships[5].institutions[0].display_name | Medical University of South Carolina |
| authorships[5].institutions[1].id | https://openalex.org/I33213144 |
| authorships[5].institutions[1].ror | https://ror.org/02y3ad647 |
| authorships[5].institutions[1].type | education |
| authorships[5].institutions[1].lineage | https://openalex.org/I33213144 |
| authorships[5].institutions[1].country_code | US |
| authorships[5].institutions[1].display_name | University of Florida |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Jennifer K. Mulligan |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Otolaryngology, Medical University of South Carolina, Charleston, SC 29425, USA, Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida Gainesville, Gainesville, FL 32611, USA |
| authorships[6].author.id | https://openalex.org/A5009698775 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-4588-3412 |
| authorships[6].author.display_name | Rita M. Ryan |
| authorships[6].countries | US |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I4210151235, https://openalex.org/I58956616 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Pediatrics-Neonatology, Case Western Reserve University, UH Rainbow Babies and Children's Hospital, Cleveland, OH 44106, USA |
| authorships[6].affiliations[1].institution_ids | https://openalex.org/I153297377 |
| authorships[6].affiliations[1].raw_affiliation_string | Department of Pediatrics-Neonatology, Medical University of South Carolina, Charleston, SC 29425, USA |
| authorships[6].institutions[0].id | https://openalex.org/I58956616 |
| authorships[6].institutions[0].ror | https://ror.org/051fd9666 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I58956616 |
| authorships[6].institutions[0].country_code | US |
| authorships[6].institutions[0].display_name | Case Western Reserve University |
| authorships[6].institutions[1].id | https://openalex.org/I153297377 |
| authorships[6].institutions[1].ror | https://ror.org/012jban78 |
| authorships[6].institutions[1].type | education |
| authorships[6].institutions[1].lineage | https://openalex.org/I153297377 |
| authorships[6].institutions[1].country_code | US |
| authorships[6].institutions[1].display_name | Medical University of South Carolina |
| authorships[6].institutions[2].id | https://openalex.org/I4210151235 |
| authorships[6].institutions[2].ror | https://ror.org/04x495f64 |
| authorships[6].institutions[2].type | healthcare |
| authorships[6].institutions[2].lineage | https://openalex.org/I2799343972, https://openalex.org/I4210151235 |
| authorships[6].institutions[2].country_code | US |
| authorships[6].institutions[2].display_name | Rainbow Babies & Children's Hospital |
| authorships[6].author_position | last |
| authorships[6].raw_author_name | Rita M. Ryan |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Pediatrics-Neonatology, Case Western Reserve University, UH Rainbow Babies and Children's Hospital, Cleveland, OH 44106, USA, Department of Pediatrics-Neonatology, Medical University of South Carolina, Charleston, SC 29425, USA |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.mdpi.com/2227-9067/8/10/879/pdf?version=1633162255 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Dexamethasone Alters Tracheal Aspirate T-Cell Cytokine Production in Ventilated Preterm Infants |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10549 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2740 |
| primary_topic.subfield.display_name | Pulmonary and Respiratory Medicine |
| primary_topic.display_name | Neonatal Respiratory Health Research |
| related_works | https://openalex.org/W3211297606, https://openalex.org/W2603361761, https://openalex.org/W2908563763, https://openalex.org/W2047100640, https://openalex.org/W3151930227, https://openalex.org/W2006581190, https://openalex.org/W28407766, https://openalex.org/W2117159970, https://openalex.org/W2205013161, https://openalex.org/W4401576787 |
| cited_by_count | 3 |
| counts_by_year[0].year | 2023 |
| counts_by_year[0].cited_by_count | 2 |
| counts_by_year[1].year | 2022 |
| counts_by_year[1].cited_by_count | 1 |
| locations_count | 5 |
| best_oa_location.id | doi:10.3390/children8100879 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2736895435 |
| best_oa_location.source.issn | 2227-9067 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2227-9067 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Children |
| best_oa_location.source.host_organization | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.mdpi.com/2227-9067/8/10/879/pdf?version=1633162255 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Children |
| best_oa_location.landing_page_url | https://doi.org/10.3390/children8100879 |
| primary_location.id | doi:10.3390/children8100879 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S2736895435 |
| primary_location.source.issn | 2227-9067 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2227-9067 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Children |
| primary_location.source.host_organization | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.mdpi.com/2227-9067/8/10/879/pdf?version=1633162255 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Children |
| primary_location.landing_page_url | https://doi.org/10.3390/children8100879 |
| publication_date | 2021-10-02 |
| publication_year | 2021 |
| referenced_works | https://openalex.org/W3161339621, https://openalex.org/W1980584372, https://openalex.org/W2065471994, https://openalex.org/W2018349449, https://openalex.org/W2904254259, https://openalex.org/W6765876561, https://openalex.org/W1508835721, https://openalex.org/W2006500041, https://openalex.org/W2067922972, https://openalex.org/W2071253158, https://openalex.org/W4248753980, https://openalex.org/W2062979901, https://openalex.org/W2195426869, https://openalex.org/W2313968093, https://openalex.org/W2418055142, https://openalex.org/W2009253992, https://openalex.org/W2788546956, https://openalex.org/W2148507750, https://openalex.org/W1980119094, https://openalex.org/W4248251600, https://openalex.org/W2128954340, https://openalex.org/W2767823698, https://openalex.org/W2118974561, https://openalex.org/W2765331223, https://openalex.org/W2067487754, https://openalex.org/W1574408743, https://openalex.org/W2938555173, https://openalex.org/W2062192476, https://openalex.org/W2560881438, https://openalex.org/W2298994227, https://openalex.org/W2778568740, https://openalex.org/W2054425276, https://openalex.org/W1993952905, https://openalex.org/W2965361454 |
| referenced_works_count | 34 |
| abstract_inverted_index.1 | 110 |
| abstract_inverted_index.3 | 112 |
| abstract_inverted_index.T | 124 |
| abstract_inverted_index.a | 104 |
| abstract_inverted_index.h | 102 |
| abstract_inverted_index.14 | 77, 94 |
| abstract_inverted_index.23 | 81 |
| abstract_inverted_index.28 | 84 |
| abstract_inverted_index.72 | 101 |
| abstract_inverted_index.TA | 47, 65, 72, 129, 174 |
| abstract_inverted_index.To | 178 |
| abstract_inverted_index.We | 58 |
| abstract_inverted_index.at | 92 |
| abstract_inverted_index.in | 10, 23, 123, 128, 149, 168, 200 |
| abstract_inverted_index.is | 44, 182 |
| abstract_inverted_index.of | 27, 69 |
| abstract_inverted_index.or | 54 |
| abstract_inverted_index.to | 83, 100, 111 |
| abstract_inverted_index.up | 99 |
| abstract_inverted_index.0/7 | 82 |
| abstract_inverted_index.6/7 | 85 |
| abstract_inverted_index.BPD | 28 |
| abstract_inverted_index.RSS | 170, 199 |
| abstract_inverted_index.TA. | 169 |
| abstract_inverted_index.The | 118 |
| abstract_inverted_index.and | 5, 50, 108, 130, 161, 164, 192 |
| abstract_inverted_index.are | 31 |
| abstract_inverted_index.for | 91 |
| abstract_inverted_index.our | 179 |
| abstract_inverted_index.the | 64, 183 |
| abstract_inverted_index.via | 139 |
| abstract_inverted_index.was | 121, 195 |
| abstract_inverted_index.who | 87 |
| abstract_inverted_index.(TA) | 26 |
| abstract_inverted_index.BPD. | 205 |
| abstract_inverted_index.IL-6 | 191 |
| abstract_inverted_index.also | 36 |
| abstract_inverted_index.born | 79 |
| abstract_inverted_index.cell | 125 |
| abstract_inverted_index.days | 114 |
| abstract_inverted_index.flow | 140 |
| abstract_inverted_index.from | 76, 80 |
| abstract_inverted_index.that | 60, 187 |
| abstract_inverted_index.this | 181, 193 |
| abstract_inverted_index.were | 74, 88, 97, 146 |
| abstract_inverted_index.with | 13, 33, 173, 197, 203 |
| abstract_inverted_index.Older | 17 |
| abstract_inverted_index.after | 55, 115, 135 |
| abstract_inverted_index.again | 109 |
| abstract_inverted_index.blood | 39 |
| abstract_inverted_index.cells | 163 |
| abstract_inverted_index.days. | 95 |
| abstract_inverted_index.first | 184 |
| abstract_inverted_index.known | 45 |
| abstract_inverted_index.least | 93 |
| abstract_inverted_index.score | 152 |
| abstract_inverted_index.study | 185 |
| abstract_inverted_index.their | 131 |
| abstract_inverted_index.there | 145 |
| abstract_inverted_index.total | 165 |
| abstract_inverted_index.weeks | 86 |
| abstract_inverted_index.which | 30 |
| abstract_inverted_index.(BPD). | 16 |
| abstract_inverted_index.(RSS), | 153 |
| abstract_inverted_index.IFN-γ | 167 |
| abstract_inverted_index.T-cell | 40, 48, 66, 190 |
| abstract_inverted_index.alters | 63 |
| abstract_inverted_index.before | 53, 103 |
| abstract_inverted_index.cells, | 156, 158, 160 |
| abstract_inverted_index.cells. | 177 |
| abstract_inverted_index.change | 122 |
| abstract_inverted_index.course | 107 |
| abstract_inverted_index.little | 43 |
| abstract_inverted_index.status | 4 |
| abstract_inverted_index.Samples | 96 |
| abstract_inverted_index.altered | 32 |
| abstract_inverted_index.improve | 2 |
| abstract_inverted_index.infants | 12, 78, 202 |
| abstract_inverted_index.outcome | 120 |
| abstract_inverted_index.percent | 154, 175 |
| abstract_inverted_index.present | 127 |
| abstract_inverted_index.preterm | 11, 70 |
| abstract_inverted_index.primary | 119 |
| abstract_inverted_index.profile | 134 |
| abstract_inverted_index.reduced | 189 |
| abstract_inverted_index.samples | 73 |
| abstract_inverted_index.support | 8 |
| abstract_inverted_index.ten-day | 105 |
| abstract_inverted_index.weaning | 9 |
| abstract_inverted_index.However, | 42 |
| abstract_inverted_index.calendar | 113 |
| abstract_inverted_index.cytokine | 21, 51, 67, 133 |
| abstract_inverted_index.evolving | 204 |
| abstract_inverted_index.improved | 198 |
| abstract_inverted_index.infants. | 71 |
| abstract_inverted_index.patients | 29 |
| abstract_inverted_index.pre-term | 201 |
| abstract_inverted_index.profiles | 22, 68 |
| abstract_inverted_index.severity | 151 |
| abstract_inverted_index.tracheal | 24 |
| abstract_inverted_index.CD4+IL-6+ | 155, 176 |
| abstract_inverted_index.CD8+IL-6+ | 157 |
| abstract_inverted_index.Following | 142 |
| abstract_inverted_index.Postnatal | 0 |
| abstract_inverted_index.aspirates | 25 |
| abstract_inverted_index.collected | 75, 98 |
| abstract_inverted_index.decreases | 148 |
| abstract_inverted_index.describes | 19 |
| abstract_inverted_index.dysplasia | 15 |
| abstract_inverted_index.exogenous | 56 |
| abstract_inverted_index.influence | 37 |
| abstract_inverted_index.phenotype | 49 |
| abstract_inverted_index.postnatal | 61 |
| abstract_inverted_index.presence. | 41 |
| abstract_inverted_index.reduction | 194 |
| abstract_inverted_index.regarding | 46 |
| abstract_inverted_index.associated | 196 |
| abstract_inverted_index.correlated | 172 |
| abstract_inverted_index.cytometry. | 141 |
| abstract_inverted_index.facilitate | 6 |
| abstract_inverted_index.knowledge, | 180 |
| abstract_inverted_index.literature | 18 |
| abstract_inverted_index.peripheral | 38 |
| abstract_inverted_index.production | 52 |
| abstract_inverted_index.treatment, | 137, 144 |
| abstract_inverted_index.ventilated | 90 |
| abstract_inverted_index.CXCR3+IL-2+ | 162 |
| abstract_inverted_index.CXCR3+IL-6+ | 159 |
| abstract_inverted_index.ascertained | 138 |
| abstract_inverted_index.initiation. | 117 |
| abstract_inverted_index.populations | 126 |
| abstract_inverted_index.respiratory | 3, 7, 150 |
| abstract_inverted_index.significant | 147 |
| abstract_inverted_index.hypothesized | 59 |
| abstract_inverted_index.mechanically | 89 |
| abstract_inverted_index.demonstrating | 186 |
| abstract_inverted_index.dexamethasone | 62, 106, 116, 136, 143, 188 |
| abstract_inverted_index.intracellular | 132, 166 |
| abstract_inverted_index.significantly | 171 |
| abstract_inverted_index.characteristic | 20 |
| abstract_inverted_index.Corticosteroids | 35 |
| abstract_inverted_index.corticosteroids | 1 |
| abstract_inverted_index.bronchopulmonary | 14 |
| abstract_inverted_index.corticosteroids. | 34, 57 |
| cited_by_percentile_year.max | 96 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5008202435 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 7 |
| corresponding_institution_ids | https://openalex.org/I153297377, https://openalex.org/I32389192 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.6299999952316284 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.66382528 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |