Dexmedetomidine attenuates acute stress-impaired learning and memory in mice by maintaining the homeostasis of intestinal flora Article Swipe
Hao Feng
,
Xing Hu
,
Yizi Lin
,
Jingni Xiao
,
Chao Dai
,
Zhao‐Lan Hu
,
Hao Feng
,
Jiao Qin
,
Li Chen
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1186/s40001-024-01832-5
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1186/s40001-024-01832-5
Dexmedetomidine (Dex) has been used in surgery to improve patients' postoperative cognitive function. However, the role of Dex in stress-induced anxiety-like behaviors and cognitive impairment is still unclear. In this study, we tested the role of Dex in anxiety-like behavior and cognitive impairment induced by acute restrictive stress and analyzed the alterations of the intestinal flora to explore the possible mechanism. Behavioral and cognitive tests, including open field test, elevated plus-maze test, novel object recognition test, and Barnes maze test, were performed. Intestinal gut Microbe 16S rRNA sequencing was analyzed. We found that intraperitoneal injection of Dex significantly improved acute restrictive stress-induced anxiety-like behavior, recognition, and memory impairment. After habituation in the environment, mice (male, 8 weeks, 18–23 g) were randomly divided into a control group (control, N = 10), dexmedetomidine group (Dex, N = 10), AS with normal saline group (AS + NS, N = 10) and AS with dexmedetomidine group (AS + Dex, N = 10). By the analysis of intestinal flora, we found that acute stress caused intestinal flora disorder in mice. Dex intervention changed the composition of the intestinal flora of acute stress mice, stabilized the ecology of the intestinal flora, and significantly increased the levels of Blautia (A genus of anaerobic bacteria) and Coprobacillus . These findings suggest that Dex attenuates acute stress-impaired learning and memory in mice by maintaining the homeostasis of intestinal flora.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- http://doi.org/10.1186/s40001-024-01832-5
- OA Status
- gold
- Cited By
- 2
- References
- 54
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4396661370
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4396661370Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1186/s40001-024-01832-5Digital Object Identifier
- Title
-
Dexmedetomidine attenuates acute stress-impaired learning and memory in mice by maintaining the homeostasis of intestinal floraWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-05-06Full publication date if available
- Authors
-
Hao Feng, Xing Hu, Yizi Lin, Jingni Xiao, Chao Dai, Zhao‐Lan Hu, Hao Feng, Jiao Qin, Li ChenList of authors in order
- Landing page
-
https://doi.org/10.1186/s40001-024-01832-5Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1186/s40001-024-01832-5Direct OA link when available
- Concepts
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Dexmedetomidine, Flora (microbiology), Habituation, Gut flora, Open field, Elevated plus maze, Anxiety, Medicine, Anesthesia, Internal medicine, Endocrinology, Immunology, Biology, Sedation, Psychiatry, Bacteria, Genetics, AudiologyTop concepts (fields/topics) attached by OpenAlex
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2Total citation count in OpenAlex
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2025: 1, 2024: 1Per-year citation counts (last 5 years)
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54Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W2988090219, https://openalex.org/W2009067373, https://openalex.org/W3202807564, https://openalex.org/W2772218995, https://openalex.org/W3131217274, https://openalex.org/W3012746975, https://openalex.org/W3111897458, https://openalex.org/W3093492766, https://openalex.org/W2572551054, https://openalex.org/W3018120946, https://openalex.org/W2255595836, https://openalex.org/W2887171036, https://openalex.org/W3192313116, https://openalex.org/W3084742155, https://openalex.org/W2950985821, https://openalex.org/W4321605018, https://openalex.org/W4224255996, https://openalex.org/W2221877984, https://openalex.org/W2914805088, https://openalex.org/W2770951077, https://openalex.org/W3092168286, https://openalex.org/W3047955255, https://openalex.org/W2981605350, https://openalex.org/W2935655759, https://openalex.org/W3020998558, https://openalex.org/W2979352217, https://openalex.org/W3028934650, https://openalex.org/W2948640754, https://openalex.org/W3028107647, https://openalex.org/W3168645654, https://openalex.org/W2902677316, https://openalex.org/W3128233015, https://openalex.org/W2568352511, https://openalex.org/W2980944208, https://openalex.org/W2948003108, https://openalex.org/W2947170763, https://openalex.org/W2756132907, https://openalex.org/W2467184611, https://openalex.org/W3033182537, https://openalex.org/W1932197482, https://openalex.org/W3127288224, https://openalex.org/W2039600269, https://openalex.org/W2152529866, https://openalex.org/W2047945207, https://openalex.org/W2113275099, https://openalex.org/W2141125135, https://openalex.org/W2754456799, https://openalex.org/W2766387403, https://openalex.org/W2029943794, https://openalex.org/W2037701117, https://openalex.org/W2067305053, https://openalex.org/W1987782068, https://openalex.org/W2988061102, https://openalex.org/W2957548845 |
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