Dextran-Coated Cerium Oxide Nanoparticles: A Computed Tomography Contrast Agent for Imaging the Gastrointestinal Tract and Inflammatory Bowel Disease Article Swipe
Pratap C. Naha
,
Jessica C. Hsu
,
Johoon Kim
,
Shrey Shah
,
Mathilde Bouché
,
Salim Si‐Mohamed
,
Derick N. Rosario‐Berríos
,
Philippe Douek
,
Maryam Hajfathalian
,
Parisa Yasini
,
Sanjay Singh
,
Mark Rosen
,
Matthew A. Morgan
,
David P. Cormode
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1021/acsnano.0c03457
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1021/acsnano.0c03457
Computed tomography (CT) is an X-ray-based medical imaging technique commonly used for noninvasive gastrointestinal tract (GIT) imaging. Iodine- and barium-based CT contrast agents are used in the clinic for GIT imaging; however, inflammatory bowel disease (IBD) imaging is challenging since iodinated and barium-based CT agents are not specific for sites of inflammation. Cerium oxide nanoparticles (CeNP) can produce strong X-ray attenuation due to cerium's k-edge at 40.4 keV but have not yet been explored for CT imaging. In addition, we hypothesized that the use of dextran as a coating material on cerium oxide nanoparticles would encourage accumulation in IBD inflammation sites in a similar fashion to other inflammatory diseases. In this study, therefore, we sought to develop a CT contrast agent, i.e., dextran-coated cerium oxide nanoparticles (Dex-CeNP) for GIT imaging with IBD. We synthesized Dex-CeNP, characterized them using various analytical tools, and examined their in vitro biocompatibility, CT contrast generation, and protective effect against oxidative stress. In vivo CT imaging was done with both healthy mice and a dextran sodium sulfate induced colitis mouse model. Dex-CeNP's CT contrast generation and accumulation in inflammation sites were compared with iopamidol, an FDA approved CT contrast agent. Dex-CeNP was found to be protective against oxidative damage. Dex-CeNP produced strong CT contrast and accumulated in the colitis area of large intestines. In addition, >97% of oral doses were cleared from the body within 24 h. Therefore, Dex-CeNP can be used as a potential CT contrast agent for imaging GIT with IBD while protecting against oxidative damage.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1021/acsnano.0c03457
- OA Status
- green
- Cited By
- 162
- References
- 57
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3045347118
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3045347118Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1021/acsnano.0c03457Digital Object Identifier
- Title
-
Dextran-Coated Cerium Oxide Nanoparticles: A Computed Tomography Contrast Agent for Imaging the Gastrointestinal Tract and Inflammatory Bowel DiseaseWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-07-21Full publication date if available
- Authors
-
Pratap C. Naha, Jessica C. Hsu, Johoon Kim, Shrey Shah, Mathilde Bouché, Salim Si‐Mohamed, Derick N. Rosario‐Berríos, Philippe Douek, Maryam Hajfathalian, Parisa Yasini, Sanjay Singh, Mark Rosen, Matthew A. Morgan, David P. CormodeList of authors in order
- Landing page
-
https://doi.org/10.1021/acsnano.0c03457Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/7484129Direct OA link when available
- Concepts
-
Inflammatory bowel disease, Medicine, Dextran, Cerium oxide, Gastrointestinal tract, Inflammation, In vivo, Colitis, Biocompatibility, Materials science, Pathology, Chemistry, Internal medicine, Oxide, Disease, Biochemistry, Metallurgy, Biology, BiotechnologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
162Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 30, 2024: 50, 2023: 37, 2022: 29, 2021: 15Per-year citation counts (last 5 years)
- References (count)
-
57Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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