Diagnostic accuracy of 1p/19q codeletion tests in oligodendroglioma: A comprehensive meta‐analysis based on a Cochrane systematic review Article Swipe
Sebastian Brandner
,
Alexandra McAleenan
,
Hayley E. Jones
,
Ashleigh Kernohan
,
Tomos Robinson
,
Lena Schmidt
,
Sarah Dawson
,
Claire Kelly
,
Emmelyn Spencer Leal
,
Claire Faulkner
,
Abigail Palmer
,
Christopher Wragg
,
Sarah Jefferies
,
Luke Vale
,
Julian P. T. Higgins
,
Kathreena M. Kurian
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1111/nan.12790
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1111/nan.12790
Codeletion of chromosomal arms 1p and 19q, in conjunction with a mutation in the isocitrate dehydrogenase 1 or 2 gene, is the molecular diagnostic criterion for oligodendroglioma, IDH mutant and 1p/19q codeleted. 1p/19q codeletion is a diagnostic marker and allows prognostication and prediction of the best drug response within IDH‐mutant tumours. We performed a Cochrane review and simple economic analysis to establish the most sensitive, specific and cost‐effective techniques for determining 1p/19q codeletion status. Fluorescent in situ hybridisation (FISH) and polymerase chain reaction (PCR)‐based loss of heterozygosity (LOH) test methods were considered as reference standard. Most techniques (FISH, chromogenic in situ hybridisation [CISH], PCR, real‐time PCR, multiplex ligation‐dependent probe amplification [MLPA], single nucleotide polymorphism [SNP] array, comparative genomic hybridisation [CGH], array CGH, next‐generation sequencing [NGS], mass spectrometry and NanoString) showed good sensitivity (few false negatives) for detection of 1p/19q codeletions in glioma, irrespective of whether FISH or PCR‐based LOH was used as the reference standard. Both NGS and SNP array had a high specificity (fewer false positives) for 1p/19q codeletion when considered against FISH as the reference standard. Our findings suggest that G banding is not a suitable test for 1p/19q analysis. Within these limits, considering cost per diagnosis and using FISH as a reference, MLPA was marginally more cost‐effective than other tests, although these economic analyses were limited by the range of available parameters, time horizon and data from multiple healthcare organisations.
Related Topics
Concepts
Oligodendroglioma
Multiplex ligation-dependent probe amplification
Multiplex
IDH1
Biology
Medicine
Oncology
Molecular biology
Bioinformatics
Genetics
Glioma
Mutation
Gene
Astrocytoma
Exon
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1111/nan.12790
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/nan.12790
- OA Status
- hybrid
- Cited By
- 22
- References
- 85
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4200182341
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4200182341Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1111/nan.12790Digital Object Identifier
- Title
-
Diagnostic accuracy of 1p/19q codeletion tests in oligodendroglioma: A comprehensive meta‐analysis based on a Cochrane systematic reviewWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-12-26Full publication date if available
- Authors
-
Sebastian Brandner, Alexandra McAleenan, Hayley E. Jones, Ashleigh Kernohan, Tomos Robinson, Lena Schmidt, Sarah Dawson, Claire Kelly, Emmelyn Spencer Leal, Claire Faulkner, Abigail Palmer, Christopher Wragg, Sarah Jefferies, Luke Vale, Julian P. T. Higgins, Kathreena M. KurianList of authors in order
- Landing page
-
https://doi.org/10.1111/nan.12790Publisher landing page
- PDF URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/nan.12790Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/nan.12790Direct OA link when available
- Concepts
-
Oligodendroglioma, Multiplex ligation-dependent probe amplification, Multiplex, IDH1, Biology, Medicine, Oncology, Molecular biology, Bioinformatics, Genetics, Glioma, Mutation, Gene, Astrocytoma, ExonTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
22Total citation count in OpenAlex
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2025: 9, 2024: 5, 2023: 5, 2022: 2, 2021: 1Per-year citation counts (last 5 years)
- References (count)
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85Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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