Diagnostic accuracy of complete blood cell count and neutrophil-to-lymphocyte, lymphocyte-to-monocyte, and platelet-to-lymphocyte ratios for neonatal infection Article Swipe
YOU?
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· 2022
· Open Access
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· DOI: https://doi.org/10.2478/abm-2022-0006
Background Complete blood cell (CBC) counts and neutrophil-to-lymphocyte (NLR), lymphocyte-to-monocyte (LMR), and platelet-to-lymphocyte ratios (PLR) are simple measurements that are conducted as part of routine diagnostic procedures. Objective To determine the diagnostic importance, specificity, and sensitivity of these measurements for the diagnosis of neonatal infections and in discriminating between neonatal sepsis and various other infections. Methods We conducted a retrospective study of data from a consecutive series of 232 neonatal patients admitted to Yildirim Beyazit University Yenimahalle Training and Research Hospital in Ankara for 2 years from 2016 to 2018. We included patients with a diagnosis of or clinically suspected infection, and healthy neonates were included as controls. Data included CBC counts, and bacterial culture results, considered the criterion standard for the diagnosis of neonatal sepsis. NLR, LMR, and PLR were calculated. We compared data using independent Student t and Mann–Whitney U tests and determined the sensitivity, specificity, and likelihood ratio (LHOR) of the characteristics for neonatal sepsis using receiver operating characteristic curve analyses. Results We included data from 155 neonatal patients with a diagnosis or suspicion of infection and 77 healthy neonates. NLR was significantly higher in neonates with sepsis or fever due to dehydration ( P < 0.001) than in neonates with other infections or healthy neonates. LMR was significantly higher in neonates with sepsis or viral infection than in those with other infections or healthy controls ( P = 0.003). In neonates with early-onset sepsis (EOS), we found cut-off values of ≥4.79 [area under curve (AUC) 0.845, 95% confidence interval (CI) 0.76–0.93, LHOR 11.6, specificity 98.7%, sensitivity 15%] for NLR, ≥1.24 (AUC 0.295; CI 0.18–0.41, LHOR 1.02, specificity 2.6%, sensitivity 100%) for LMR, and ≥37.72 (AUC 0.268; CI 0.15–0.39, LHOR 0.86, specificity 7.8%, sensitivity 80%) for PLR. We found cut-off values of ≥4.94 (AUC 0.667; CI 0.56–0.77, LHOR 4.16, specificity 98.7%, sensitivity 5.4%) for NLR and ≥10.92 (AUC 0.384; CI 0.26–0.51, LHOR 6.24, specificity 98.7%, sensitivity 8.1%) for LMR in those with late-onset sepsis (LOS). Conclusions CBCs, NLR, LMR, and PLR may be useful for the differential diagnosis of EOS and LOS, and neonates with sepsis from those with other infection. NLR may be a useful diagnostic test to identify neonatal patients with septicemia more quickly than other commonly used diagnostic tests such as blood cultures. NLR has high specificity and LHOR, but low sensitivity.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.2478/abm-2022-0006
- https://www.sciendo.com/pdf/10.2478/abm-2022-0006
- OA Status
- hybrid
- Cited By
- 8
- References
- 32
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4220710769
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4220710769Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.2478/abm-2022-0006Digital Object Identifier
- Title
-
Diagnostic accuracy of complete blood cell count and neutrophil-to-lymphocyte, lymphocyte-to-monocyte, and platelet-to-lymphocyte ratios for neonatal infectionWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-02-01Full publication date if available
- Authors
-
Abdullah Kurt, Merve Sezen Tosun, Nilgün AltuntaşList of authors in order
- Landing page
-
https://doi.org/10.2478/abm-2022-0006Publisher landing page
- PDF URL
-
https://www.sciendo.com/pdf/10.2478/abm-2022-0006Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
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https://www.sciendo.com/pdf/10.2478/abm-2022-0006Direct OA link when available
- Concepts
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Medicine, Sepsis, Neonatal sepsis, Lymphocyte, Receiver operating characteristic, Monocyte, Immunology, Platelet, Internal medicine, Area under the curve, Retrospective cohort study, Gastroenterology, Complete blood count, Neonatal infection, Pregnancy, Biology, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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8Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2024: 3, 2023: 2, 2022: 1Per-year citation counts (last 5 years)
- References (count)
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32Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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