Diagnostic and prognostic value of heparin-binding protein in infection and critically ill adult patients: A systematic review and meta-analysis Article Swipe
Wenshan Yang
,
Wenjie Zhang
,
Y. Huo
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.65140/gimn202501.5
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.65140/gimn202501.5
Purpose: In this study, we seek to evaluate the diagnostic value of Heparin-binding protein (HBP) levels in infection and intended to investigate the prognostic value of HBP in critically ill adult patients. Methods：We searched PubMed, Web of science, EMBASE and the Cochrane Database to identify relevant studies on June 2023. We included studies on adult patients with infection or critically ill that reported HBP levels and the data required to create 2x2 tables. We used R software, Revman 5.4 and Stats/MP 17.0 to analyze the pooled diagnostic and prognostic accuracy outcomes. Quality Assessment of Diagnostic Accuracy Studies 2 tool (QUADAS-2) was used to assess the risk of bias of included studies. This study is registered with PROSPERO (CRD42023421081). Results: Fifty-six studies with 11486 patients were identified in our present study. Most included studies demonstrated a strong correlation between HBP levels and infection and severity of disease. HBP had a pooled sensitivity of 0.87 (95% CI, 0.82–0.91), a pooled specificity of 0.87 (95% CI, 0.79–0.92) and an AUC of 0.93 (95% CI, 0.91–0.95) for the diagnosis of infection. Otherwise, HBP had a pooled sensitivity of 0.77 (95% CI, 0.74–0.80), a pooled specificity of 0.72 (95% CI, 0.68–0.76) and an AUC of 0.81 (95% CI, 0.78–0.85) for the prognosis of critically ill adult patients. We demonstrated that HBP has better diagnostic and prognostic role of infection and critically ill than Procalcitonin, CRP (C-reactive protein) and WBC (White Blood Cell) in adult patients. Conclusions: The diagnostic ability of HBP is beneficial for early recognition of infection, which showed both high sensitivity and specificity in infectious diseases. In addition, our study revealed that HBP plays role of detecting aggravation of critically diseases, including organ dysfunction and mortality.
Related Topics
Concepts
No concepts available.
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.65140/gimn202501.5
- https://pangu.press/journal/gimn/1/1/5/pdf
- OA Status
- hybrid
- References
- 76
- OpenAlex ID
- https://openalex.org/W4415295491
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4415295491Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.65140/gimn202501.5Digital Object Identifier
- Title
-
Diagnostic and prognostic value of heparin-binding protein in infection and critically ill adult patients: A systematic review and meta-analysisWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-09-19Full publication date if available
- Authors
-
Wenshan Yang, Wenjie Zhang, Y. HuoList of authors in order
- Landing page
-
https://doi.org/10.65140/gimn202501.5Publisher landing page
- PDF URL
-
https://pangu.press/journal/gimn/1/1/5/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://pangu.press/journal/gimn/1/1/5/pdfDirect OA link when available
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
76Number of works referenced by this work
Full payload
| id | https://openalex.org/W4415295491 |
|---|---|
| doi | https://doi.org/10.65140/gimn202501.5 |
| ids.doi | https://doi.org/10.65140/gimn202501.5 |
| ids.openalex | https://openalex.org/W4415295491 |
| fwci | 0.0 |
| type | review |
| title | Diagnostic and prognostic value of heparin-binding protein in infection and critically ill adult patients: A systematic review and meta-analysis |
| biblio.issue | 1 |
| biblio.volume | 1 |
| biblio.last_page | 4 |
| biblio.first_page | 1 |
| topics[0].id | https://openalex.org/T10218 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9998999834060669 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2713 |
| topics[0].subfield.display_name | Epidemiology |
| topics[0].display_name | Sepsis Diagnosis and Treatment |
| topics[1].id | https://openalex.org/T11861 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9945999979972839 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2706 |
| topics[1].subfield.display_name | Critical Care and Intensive Care Medicine |
| topics[1].display_name | Thermal Regulation in Medicine |
| topics[2].id | https://openalex.org/T11681 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9940000176429749 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2706 |
| topics[2].subfield.display_name | Critical Care and Intensive Care Medicine |
| topics[2].display_name | Nosocomial Infections in ICU |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| language | en |
| locations[0].id | doi:10.65140/gimn202501.5 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S5407052922 |
| locations[0].source.issn | 3106-0137 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 3106-0137 |
| locations[0].source.is_core | False |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Global Insights in Medicine and Nursing |
| locations[0].source.host_organization | |
| locations[0].source.host_organization_name | |
| locations[0].source.host_organization_lineage | |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://pangu.press/journal/gimn/1/1/5/pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Global Insights in Medicine and Nursing |
| locations[0].landing_page_url | https://doi.org/10.65140/gimn202501.5 |
| indexed_in | crossref |
| authorships[0].author.id | https://openalex.org/A5102468275 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Wenshan Yang |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Critical Care Medicine, The Hospital of 82ND Group Army PLA, Baoding, 071000, China. |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Wenshan Yang |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Critical Care Medicine, The Hospital of 82ND Group Army PLA, Baoding, 071000, China. |
| authorships[1].author.id | https://openalex.org/A5100385514 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-7753-695X |
| authorships[1].author.display_name | Wenjie Zhang |
| authorships[1].affiliations[0].raw_affiliation_string | Systematic Review Solutions Ltd, Beijing, China. |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | WenJie Zhang |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Systematic Review Solutions Ltd, Beijing, China. |
| authorships[2].author.id | https://openalex.org/A5101671209 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-1902-5761 |
| authorships[2].author.display_name | Y. Huo |
| authorships[2].affiliations[0].raw_affiliation_string | Systematic Review Solutions Ltd, Beijing, China. |
| authorships[2].author_position | last |
| authorships[2].raw_author_name | Yan Huo |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Systematic Review Solutions Ltd, Beijing, China. |
| has_content.pdf | True |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://pangu.press/journal/gimn/1/1/5/pdf |
| open_access.oa_status | hybrid |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-18T00:00:00 |
| display_name | Diagnostic and prognostic value of heparin-binding protein in infection and critically ill adult patients: A systematic review and meta-analysis |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-27T01:12:40.094763 |
| primary_topic.id | https://openalex.org/T10218 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9998999834060669 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2713 |
| primary_topic.subfield.display_name | Epidemiology |
| primary_topic.display_name | Sepsis Diagnosis and Treatment |
| cited_by_count | 0 |
| locations_count | 1 |
| best_oa_location.id | doi:10.65140/gimn202501.5 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S5407052922 |
| best_oa_location.source.issn | 3106-0137 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 3106-0137 |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Global Insights in Medicine and Nursing |
| best_oa_location.source.host_organization | |
| best_oa_location.source.host_organization_name | |
| best_oa_location.source.host_organization_lineage | |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://pangu.press/journal/gimn/1/1/5/pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Global Insights in Medicine and Nursing |
| best_oa_location.landing_page_url | https://doi.org/10.65140/gimn202501.5 |
| primary_location.id | doi:10.65140/gimn202501.5 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S5407052922 |
| primary_location.source.issn | 3106-0137 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 3106-0137 |
| primary_location.source.is_core | False |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Global Insights in Medicine and Nursing |
| primary_location.source.host_organization | |
| primary_location.source.host_organization_name | |
| primary_location.source.host_organization_lineage | |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://pangu.press/journal/gimn/1/1/5/pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Global Insights in Medicine and Nursing |
| primary_location.landing_page_url | https://doi.org/10.65140/gimn202501.5 |
| publication_date | 2025-09-19 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W2280404143, https://openalex.org/W2985671765, https://openalex.org/W2761236748, https://openalex.org/W2990895485, https://openalex.org/W3109283730, https://openalex.org/W2760052617, https://openalex.org/W4313424514, https://openalex.org/W4387612662, https://openalex.org/W2916492277, https://openalex.org/W2952887510, https://openalex.org/W1999548148, https://openalex.org/W4220891119, https://openalex.org/W2165660408, https://openalex.org/W3009625308, https://openalex.org/W3139053123, https://openalex.org/W2892401664, https://openalex.org/W4283359519, https://openalex.org/W4379537452, https://openalex.org/W2603079123, https://openalex.org/W2152946780, https://openalex.org/W3011495493, https://openalex.org/W2123343346, https://openalex.org/W4391390051, https://openalex.org/W4399880648, https://openalex.org/W3102638036, https://openalex.org/W3118615836, https://openalex.org/W2107638293, https://openalex.org/W4294225698, https://openalex.org/W4285116077, https://openalex.org/W3087096824, https://openalex.org/W2095504106, https://openalex.org/W2109323060, https://openalex.org/W2064324041, https://openalex.org/W4200013443, https://openalex.org/W2998626164, https://openalex.org/W2791444493, https://openalex.org/W4291003835, https://openalex.org/W2902119759, https://openalex.org/W1690947061, https://openalex.org/W2885615325, https://openalex.org/W4200413366, https://openalex.org/W2292094573, https://openalex.org/W4379984942, https://openalex.org/W2108931019, https://openalex.org/W2169703382, https://openalex.org/W1977700506, https://openalex.org/W2182981871, https://openalex.org/W3213012874, https://openalex.org/W4223579804, https://openalex.org/W3143581796, https://openalex.org/W4318756974, https://openalex.org/W2979956661, https://openalex.org/W4292457636, https://openalex.org/W4283124456, https://openalex.org/W4294032373, https://openalex.org/W3093284534, https://openalex.org/W3168871779, https://openalex.org/W2492709547, https://openalex.org/W3121136349, https://openalex.org/W3094028473, https://openalex.org/W3197000230, https://openalex.org/W2743563188, https://openalex.org/W3039174005, https://openalex.org/W4232317694, https://openalex.org/W3145200153, https://openalex.org/W2766012877, https://openalex.org/W2305218600, https://openalex.org/W4300979673, https://openalex.org/W4368348040, https://openalex.org/W2950239562, https://openalex.org/W3175142430, https://openalex.org/W2942085804, https://openalex.org/W2947062919, https://openalex.org/W2752063292, https://openalex.org/W2006000223, https://openalex.org/W4229006431 |
| referenced_works_count | 76 |
| abstract_inverted_index.2 | 97 |
| abstract_inverted_index.R | 75 |
| abstract_inverted_index.a | 134, 148, 156, 180, 188 |
| abstract_inverted_index.In | 1, 263 |
| abstract_inverted_index.We | 50, 73, 212 |
| abstract_inverted_index.an | 165, 197 |
| abstract_inverted_index.in | 16, 27, 126, 237, 260 |
| abstract_inverted_index.is | 113, 246 |
| abstract_inverted_index.of | 11, 25, 36, 93, 106, 108, 144, 151, 159, 167, 175, 183, 191, 199, 207, 222, 244, 251, 272, 275 |
| abstract_inverted_index.on | 47, 53 |
| abstract_inverted_index.or | 58 |
| abstract_inverted_index.to | 6, 20, 43, 69, 82, 102 |
| abstract_inverted_index.we | 4 |
| abstract_inverted_index.2x2 | 71 |
| abstract_inverted_index.5.4 | 78 |
| abstract_inverted_index.AUC | 166, 198 |
| abstract_inverted_index.CI, | 154, 162, 170, 186, 194, 202 |
| abstract_inverted_index.CRP | 229 |
| abstract_inverted_index.HBP | 26, 63, 138, 146, 178, 215, 245, 269 |
| abstract_inverted_index.The | 241 |
| abstract_inverted_index.WBC | 233 |
| abstract_inverted_index.Web | 35 |
| abstract_inverted_index.and | 18, 39, 65, 79, 87, 140, 142, 164, 196, 219, 224, 232, 258, 281 |
| abstract_inverted_index.for | 172, 204, 248 |
| abstract_inverted_index.had | 147, 179 |
| abstract_inverted_index.has | 216 |
| abstract_inverted_index.ill | 29, 60, 209, 226 |
| abstract_inverted_index.our | 127, 265 |
| abstract_inverted_index.the | 8, 22, 40, 66, 84, 104, 173, 205 |
| abstract_inverted_index.was | 100 |
| abstract_inverted_index.(95% | 153, 161, 169, 185, 193, 201 |
| abstract_inverted_index.0.72 | 192 |
| abstract_inverted_index.0.77 | 184 |
| abstract_inverted_index.0.81 | 200 |
| abstract_inverted_index.0.87 | 152, 160 |
| abstract_inverted_index.0.93 | 168 |
| abstract_inverted_index.17.0 | 81 |
| abstract_inverted_index.June | 48 |
| abstract_inverted_index.Most | 130 |
| abstract_inverted_index.This | 111 |
| abstract_inverted_index.bias | 107 |
| abstract_inverted_index.both | 255 |
| abstract_inverted_index.data | 67 |
| abstract_inverted_index.high | 256 |
| abstract_inverted_index.risk | 105 |
| abstract_inverted_index.role | 221, 271 |
| abstract_inverted_index.seek | 5 |
| abstract_inverted_index.than | 227 |
| abstract_inverted_index.that | 61, 214, 268 |
| abstract_inverted_index.this | 2 |
| abstract_inverted_index.tool | 98 |
| abstract_inverted_index.used | 74, 101 |
| abstract_inverted_index.were | 124 |
| abstract_inverted_index.with | 56, 115, 121 |
| abstract_inverted_index.(HBP) | 14 |
| abstract_inverted_index.11486 | 122 |
| abstract_inverted_index.2023. | 49 |
| abstract_inverted_index.Blood | 235 |
| abstract_inverted_index.Cell) | 236 |
| abstract_inverted_index.adult | 30, 54, 210, 238 |
| abstract_inverted_index.early | 249 |
| abstract_inverted_index.organ | 279 |
| abstract_inverted_index.plays | 270 |
| abstract_inverted_index.study | 112, 266 |
| abstract_inverted_index.value | 10, 24 |
| abstract_inverted_index.which | 253 |
| abstract_inverted_index.(White | 234 |
| abstract_inverted_index.EMBASE | 38 |
| abstract_inverted_index.Revman | 77 |
| abstract_inverted_index.assess | 103 |
| abstract_inverted_index.better | 217 |
| abstract_inverted_index.create | 70 |
| abstract_inverted_index.levels | 15, 64, 139 |
| abstract_inverted_index.pooled | 85, 149, 157, 181, 189 |
| abstract_inverted_index.showed | 254 |
| abstract_inverted_index.strong | 135 |
| abstract_inverted_index.study, | 3 |
| abstract_inverted_index.study. | 129 |
| abstract_inverted_index.PubMed, | 34 |
| abstract_inverted_index.Quality | 91 |
| abstract_inverted_index.Studies | 96 |
| abstract_inverted_index.ability | 243 |
| abstract_inverted_index.analyze | 83 |
| abstract_inverted_index.between | 137 |
| abstract_inverted_index.present | 128 |
| abstract_inverted_index.protein | 13 |
| abstract_inverted_index.studies | 46, 52, 120, 132 |
| abstract_inverted_index.tables. | 72 |
| abstract_inverted_index.Accuracy | 95 |
| abstract_inverted_index.Cochrane | 41 |
| abstract_inverted_index.Database | 42 |
| abstract_inverted_index.PROSPERO | 116 |
| abstract_inverted_index.Purpose: | 0 |
| abstract_inverted_index.Results: | 118 |
| abstract_inverted_index.Stats/MP | 80 |
| abstract_inverted_index.accuracy | 89 |
| abstract_inverted_index.disease. | 145 |
| abstract_inverted_index.evaluate | 7 |
| abstract_inverted_index.identify | 44 |
| abstract_inverted_index.included | 51, 109, 131 |
| abstract_inverted_index.intended | 19 |
| abstract_inverted_index.patients | 55, 123 |
| abstract_inverted_index.protein) | 231 |
| abstract_inverted_index.relevant | 45 |
| abstract_inverted_index.reported | 62 |
| abstract_inverted_index.required | 68 |
| abstract_inverted_index.revealed | 267 |
| abstract_inverted_index.science, | 37 |
| abstract_inverted_index.searched | 33 |
| abstract_inverted_index.severity | 143 |
| abstract_inverted_index.studies. | 110 |
| abstract_inverted_index.Fifty-six | 119 |
| abstract_inverted_index.addition, | 264 |
| abstract_inverted_index.detecting | 273 |
| abstract_inverted_index.diagnosis | 174 |
| abstract_inverted_index.diseases, | 277 |
| abstract_inverted_index.diseases. | 262 |
| abstract_inverted_index.including | 278 |
| abstract_inverted_index.infection | 17, 57, 141, 223 |
| abstract_inverted_index.outcomes. | 90 |
| abstract_inverted_index.patients. | 31, 211, 239 |
| abstract_inverted_index.prognosis | 206 |
| abstract_inverted_index.software, | 76 |
| abstract_inverted_index.(QUADAS-2) | 99 |
| abstract_inverted_index.Assessment | 92 |
| abstract_inverted_index.Diagnostic | 94 |
| abstract_inverted_index.Otherwise, | 177 |
| abstract_inverted_index.beneficial | 247 |
| abstract_inverted_index.critically | 28, 59, 208, 225, 276 |
| abstract_inverted_index.diagnostic | 9, 86, 218, 242 |
| abstract_inverted_index.identified | 125 |
| abstract_inverted_index.infection, | 252 |
| abstract_inverted_index.infection. | 176 |
| abstract_inverted_index.infectious | 261 |
| abstract_inverted_index.mortality. | 282 |
| abstract_inverted_index.prognostic | 23, 88, 220 |
| abstract_inverted_index.registered | 114 |
| abstract_inverted_index.(C-reactive | 230 |
| abstract_inverted_index.aggravation | 274 |
| abstract_inverted_index.correlation | 136 |
| abstract_inverted_index.dysfunction | 280 |
| abstract_inverted_index.investigate | 21 |
| abstract_inverted_index.recognition | 250 |
| abstract_inverted_index.sensitivity | 150, 182, 257 |
| abstract_inverted_index.specificity | 158, 190, 259 |
| abstract_inverted_index.0.68–0.76) | 195 |
| abstract_inverted_index.0.78–0.85) | 203 |
| abstract_inverted_index.0.79–0.92) | 163 |
| abstract_inverted_index.0.91–0.95) | 171 |
| abstract_inverted_index.Conclusions: | 240 |
| abstract_inverted_index.Methods：We | 32 |
| abstract_inverted_index.demonstrated | 133, 213 |
| abstract_inverted_index.0.74–0.80), | 187 |
| abstract_inverted_index.0.82–0.91), | 155 |
| abstract_inverted_index.Procalcitonin, | 228 |
| abstract_inverted_index.Heparin-binding | 12 |
| abstract_inverted_index.(CRD42023421081). | 117 |
| cited_by_percentile_year | |
| countries_distinct_count | 0 |
| institutions_distinct_count | 3 |
| citation_normalized_percentile.value | 0.63569845 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |