Diallel panel reveals a significant impact of low-frequency genetic variants on gene expression variation in yeast Article Swipe
Andreas Tsouris
,
Gauthier Brach
,
Anne Friedrich
,
Jing Hou
,
Joseph Schacherer
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1038/s44320-024-00021-0
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1038/s44320-024-00021-0
Unraveling the genetic sources of gene expression variation is essential to better understand the origins of phenotypic diversity in natural populations. Genome-wide association studies identified thousands of variants involved in gene expression variation, however, variants detected only explain part of the heritability. In fact, variants such as low-frequency and structural variants (SVs) are poorly captured in association studies. To assess the impact of these variants on gene expression variation, we explored a half-diallel panel composed of 323 hybrids originated from pairwise crosses of 26 natural Saccharomyces cerevisiae isolates. Using short- and long-read sequencing strategies, we established an exhaustive catalog of single nucleotide polymorphisms (SNPs) and SVs for this panel. Combining this dataset with the transcriptomes of all hybrids, we comprehensively mapped SNPs and SVs associated with gene expression variation. While SVs impact gene expression variation, SNPs exhibit a higher effect size with an overrepresentation of low-frequency variants compared to common ones. These results reinforce the importance of dissecting the heritability of complex traits with a comprehensive catalog of genetic variants at the population level.
Related Topics
Concepts
Biology
Genetics
Single-nucleotide polymorphism
Genetic variation
Heritability
Genome-wide association study
Gene
Genetic association
Diallel cross
Genotype
Hybrid
Botany
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s44320-024-00021-0
- OA Status
- gold
- Cited By
- 5
- References
- 63
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4391822624
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4391822624Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1038/s44320-024-00021-0Digital Object Identifier
- Title
-
Diallel panel reveals a significant impact of low-frequency genetic variants on gene expression variation in yeastWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-02-14Full publication date if available
- Authors
-
Andreas Tsouris, Gauthier Brach, Anne Friedrich, Jing Hou, Joseph SchachererList of authors in order
- Landing page
-
https://doi.org/10.1038/s44320-024-00021-0Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1038/s44320-024-00021-0Direct OA link when available
- Concepts
-
Biology, Genetics, Single-nucleotide polymorphism, Genetic variation, Heritability, Genome-wide association study, Gene, Genetic association, Diallel cross, Genotype, Hybrid, BotanyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
5Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 2, 2023: 1Per-year citation counts (last 5 years)
- References (count)
-
63Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4391822624 |
|---|---|
| doi | https://doi.org/10.1038/s44320-024-00021-0 |
| ids.doi | https://doi.org/10.1038/s44320-024-00021-0 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/38355920 |
| ids.openalex | https://openalex.org/W4391822624 |
| fwci | 4.37680065 |
| mesh[0].qualifier_ui | Q000235 |
| mesh[0].descriptor_ui | D012441 |
| mesh[0].is_major_topic | True |
| mesh[0].qualifier_name | genetics |
| mesh[0].descriptor_name | Saccharomyces cerevisiae |
| mesh[1].qualifier_ui | Q000378 |
| mesh[1].descriptor_ui | D012441 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | metabolism |
| mesh[1].descriptor_name | Saccharomyces cerevisiae |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D055106 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Genome-Wide Association Study |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D015870 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Gene Expression |
| mesh[4].qualifier_ui | Q000235 |
| mesh[4].descriptor_ui | D020641 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | genetics |
| mesh[4].descriptor_name | Polymorphism, Single Nucleotide |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D014644 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Genetic Variation |
| mesh[6].qualifier_ui | Q000235 |
| mesh[6].descriptor_ui | D012441 |
| mesh[6].is_major_topic | True |
| mesh[6].qualifier_name | genetics |
| mesh[6].descriptor_name | Saccharomyces cerevisiae |
| mesh[7].qualifier_ui | Q000378 |
| mesh[7].descriptor_ui | D012441 |
| mesh[7].is_major_topic | True |
| mesh[7].qualifier_name | metabolism |
| mesh[7].descriptor_name | Saccharomyces cerevisiae |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D055106 |
| mesh[8].is_major_topic | True |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Genome-Wide Association Study |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D015870 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Gene Expression |
| mesh[10].qualifier_ui | Q000235 |
| mesh[10].descriptor_ui | D020641 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | genetics |
| mesh[10].descriptor_name | Polymorphism, Single Nucleotide |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D014644 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Genetic Variation |
| mesh[12].qualifier_ui | Q000235 |
| mesh[12].descriptor_ui | D012441 |
| mesh[12].is_major_topic | True |
| mesh[12].qualifier_name | genetics |
| mesh[12].descriptor_name | Saccharomyces cerevisiae |
| mesh[13].qualifier_ui | Q000378 |
| mesh[13].descriptor_ui | D012441 |
| mesh[13].is_major_topic | True |
| mesh[13].qualifier_name | metabolism |
| mesh[13].descriptor_name | Saccharomyces cerevisiae |
| mesh[14].qualifier_ui | |
| mesh[14].descriptor_ui | D055106 |
| mesh[14].is_major_topic | True |
| mesh[14].qualifier_name | |
| mesh[14].descriptor_name | Genome-Wide Association Study |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D015870 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Gene Expression |
| mesh[16].qualifier_ui | Q000235 |
| mesh[16].descriptor_ui | D020641 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | genetics |
| mesh[16].descriptor_name | Polymorphism, Single Nucleotide |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D014644 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Genetic Variation |
| mesh[18].qualifier_ui | Q000235 |
| mesh[18].descriptor_ui | D012441 |
| mesh[18].is_major_topic | True |
| mesh[18].qualifier_name | genetics |
| mesh[18].descriptor_name | Saccharomyces cerevisiae |
| mesh[19].qualifier_ui | Q000378 |
| mesh[19].descriptor_ui | D012441 |
| mesh[19].is_major_topic | True |
| mesh[19].qualifier_name | metabolism |
| mesh[19].descriptor_name | Saccharomyces cerevisiae |
| mesh[20].qualifier_ui | |
| mesh[20].descriptor_ui | D055106 |
| mesh[20].is_major_topic | True |
| mesh[20].qualifier_name | |
| mesh[20].descriptor_name | Genome-Wide Association Study |
| mesh[21].qualifier_ui | |
| mesh[21].descriptor_ui | D015870 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | |
| mesh[21].descriptor_name | Gene Expression |
| mesh[22].qualifier_ui | Q000235 |
| mesh[22].descriptor_ui | D020641 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | genetics |
| mesh[22].descriptor_name | Polymorphism, Single Nucleotide |
| mesh[23].qualifier_ui | |
| mesh[23].descriptor_ui | D014644 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | |
| mesh[23].descriptor_name | Genetic Variation |
| type | article |
| title | Diallel panel reveals a significant impact of low-frequency genetic variants on gene expression variation in yeast |
| biblio.issue | 4 |
| biblio.volume | 20 |
| biblio.last_page | 373 |
| biblio.first_page | 362 |
| grants[0].funder | https://openalex.org/F4320320883 |
| grants[0].award_id | ANR-10-IDEX-0002 |
| grants[0].funder_display_name | Agence Nationale de la Recherche |
| grants[1].funder | https://openalex.org/F4320320883 |
| grants[1].award_id | ANR-22-CE12-0023-01 |
| grants[1].funder_display_name | Agence Nationale de la Recherche |
| grants[2].funder | https://openalex.org/F4320332161 |
| grants[2].award_id | GM147040_01 |
| grants[2].funder_display_name | National Institutes of Health |
| grants[3].funder | https://openalex.org/F4320338453 |
| grants[3].award_id | CoG 772505 |
| grants[3].funder_display_name | HORIZON EUROPE European Research Council |
| topics[0].id | https://openalex.org/T11468 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.998199999332428 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1311 |
| topics[0].subfield.display_name | Genetics |
| topics[0].display_name | Genetic Mapping and Diversity in Plants and Animals |
| topics[1].id | https://openalex.org/T10497 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9940999746322632 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | Fungal and yeast genetics research |
| topics[2].id | https://openalex.org/T10261 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.993399977684021 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1311 |
| topics[2].subfield.display_name | Genetics |
| topics[2].display_name | Genetic Associations and Epidemiology |
| funders[0].id | https://openalex.org/F4320320883 |
| funders[0].ror | https://ror.org/00rbzpz17 |
| funders[0].display_name | Agence Nationale de la Recherche |
| funders[1].id | https://openalex.org/F4320332161 |
| funders[1].ror | https://ror.org/01cwqze88 |
| funders[1].display_name | National Institutes of Health |
| funders[2].id | https://openalex.org/F4320338453 |
| funders[2].ror | |
| funders[2].display_name | HORIZON EUROPE European Research Council |
| is_xpac | False |
| apc_list.value | 5000 |
| apc_list.currency | USD |
| apc_list.value_usd | 5000 |
| apc_paid.value | 5000 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 5000 |
| concepts[0].id | https://openalex.org/C86803240 |
| concepts[0].level | 0 |
| concepts[0].score | 0.8839998245239258 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[0].display_name | Biology |
| concepts[1].id | https://openalex.org/C54355233 |
| concepts[1].level | 1 |
| concepts[1].score | 0.7512523531913757 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[1].display_name | Genetics |
| concepts[2].id | https://openalex.org/C153209595 |
| concepts[2].level | 4 |
| concepts[2].score | 0.6937506198883057 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q501128 |
| concepts[2].display_name | Single-nucleotide polymorphism |
| concepts[3].id | https://openalex.org/C68873052 |
| concepts[3].level | 3 |
| concepts[3].score | 0.6913750767707825 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q349856 |
| concepts[3].display_name | Genetic variation |
| concepts[4].id | https://openalex.org/C161890455 |
| concepts[4].level | 2 |
| concepts[4].score | 0.6360529065132141 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q1503548 |
| concepts[4].display_name | Heritability |
| concepts[5].id | https://openalex.org/C106208931 |
| concepts[5].level | 5 |
| concepts[5].score | 0.5244144201278687 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q1098876 |
| concepts[5].display_name | Genome-wide association study |
| concepts[6].id | https://openalex.org/C104317684 |
| concepts[6].level | 2 |
| concepts[6].score | 0.521750807762146 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[6].display_name | Gene |
| concepts[7].id | https://openalex.org/C186413461 |
| concepts[7].level | 5 |
| concepts[7].score | 0.48846665024757385 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q744727 |
| concepts[7].display_name | Genetic association |
| concepts[8].id | https://openalex.org/C67637954 |
| concepts[8].level | 3 |
| concepts[8].score | 0.47126030921936035 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q5270567 |
| concepts[8].display_name | Diallel cross |
| concepts[9].id | https://openalex.org/C135763542 |
| concepts[9].level | 3 |
| concepts[9].score | 0.3368615508079529 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q106016 |
| concepts[9].display_name | Genotype |
| concepts[10].id | https://openalex.org/C48189365 |
| concepts[10].level | 2 |
| concepts[10].score | 0.1977546215057373 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q42621 |
| concepts[10].display_name | Hybrid |
| concepts[11].id | https://openalex.org/C59822182 |
| concepts[11].level | 1 |
| concepts[11].score | 0.0 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q441 |
| concepts[11].display_name | Botany |
| keywords[0].id | https://openalex.org/keywords/biology |
| keywords[0].score | 0.8839998245239258 |
| keywords[0].display_name | Biology |
| keywords[1].id | https://openalex.org/keywords/genetics |
| keywords[1].score | 0.7512523531913757 |
| keywords[1].display_name | Genetics |
| keywords[2].id | https://openalex.org/keywords/single-nucleotide-polymorphism |
| keywords[2].score | 0.6937506198883057 |
| keywords[2].display_name | Single-nucleotide polymorphism |
| keywords[3].id | https://openalex.org/keywords/genetic-variation |
| keywords[3].score | 0.6913750767707825 |
| keywords[3].display_name | Genetic variation |
| keywords[4].id | https://openalex.org/keywords/heritability |
| keywords[4].score | 0.6360529065132141 |
| keywords[4].display_name | Heritability |
| keywords[5].id | https://openalex.org/keywords/genome-wide-association-study |
| keywords[5].score | 0.5244144201278687 |
| keywords[5].display_name | Genome-wide association study |
| keywords[6].id | https://openalex.org/keywords/gene |
| keywords[6].score | 0.521750807762146 |
| keywords[6].display_name | Gene |
| keywords[7].id | https://openalex.org/keywords/genetic-association |
| keywords[7].score | 0.48846665024757385 |
| keywords[7].display_name | Genetic association |
| keywords[8].id | https://openalex.org/keywords/diallel-cross |
| keywords[8].score | 0.47126030921936035 |
| keywords[8].display_name | Diallel cross |
| keywords[9].id | https://openalex.org/keywords/genotype |
| keywords[9].score | 0.3368615508079529 |
| keywords[9].display_name | Genotype |
| keywords[10].id | https://openalex.org/keywords/hybrid |
| keywords[10].score | 0.1977546215057373 |
| keywords[10].display_name | Hybrid |
| language | en |
| locations[0].id | doi:10.1038/s44320-024-00021-0 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S200893805 |
| locations[0].source.issn | 1744-4292 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1744-4292 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Molecular Systems Biology |
| locations[0].source.host_organization | https://openalex.org/P4310319965 |
| locations[0].source.host_organization_name | Springer Nature |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310319965 |
| locations[0].license | cc-by |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Molecular Systems Biology |
| locations[0].landing_page_url | https://doi.org/10.1038/s44320-024-00021-0 |
| locations[1].id | pmid:38355920 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Molecular systems biology |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/38355920 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:10987670 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Mol Syst Biol |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/10987670 |
| locations[3].id | pmh:oai:doaj.org/article:8a111588ffe7413683c2d11289da40b8 |
| locations[3].is_oa | False |
| locations[3].source.id | https://openalex.org/S4306401280 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[3].source.host_organization | |
| locations[3].source.host_organization_name | |
| locations[3].source.host_organization_lineage | |
| locations[3].license | |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | article |
| locations[3].license_id | |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Molecular Systems Biology, Vol 20, Iss 4, Pp 362-373 (2024) |
| locations[3].landing_page_url | https://doaj.org/article/8a111588ffe7413683c2d11289da40b8 |
| locations[4].id | pmh:oai:HAL:hal-04590817v1 |
| locations[4].is_oa | True |
| locations[4].source.id | https://openalex.org/S4306402512 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | HAL (Le Centre pour la Communication Scientifique Directe) |
| locations[4].source.host_organization | https://openalex.org/I1294671590 |
| locations[4].source.host_organization_name | Centre National de la Recherche Scientifique |
| locations[4].source.host_organization_lineage | https://openalex.org/I1294671590 |
| locations[4].license | other-oa |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | Journal articles |
| locations[4].license_id | https://openalex.org/licenses/other-oa |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | Molecular Systems Biology, 2024, 20 (4), pp.362-373. ⟨10.1038/s44320-024-00021-0⟩ |
| locations[4].landing_page_url | https://hal.science/hal-04590817 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5026136668 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-5375-0660 |
| authorships[0].author.display_name | Andreas Tsouris |
| authorships[0].countries | FR |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I1294671590, https://openalex.org/I68947357 |
| authorships[0].affiliations[0].raw_affiliation_string | Université de Strasbourg, CNRS GMGM UMR 7156 Strasbourg France |
| authorships[0].institutions[0].id | https://openalex.org/I1294671590 |
| authorships[0].institutions[0].ror | https://ror.org/02feahw73 |
| authorships[0].institutions[0].type | government |
| authorships[0].institutions[0].lineage | https://openalex.org/I1294671590 |
| authorships[0].institutions[0].country_code | FR |
| authorships[0].institutions[0].display_name | Centre National de la Recherche Scientifique |
| authorships[0].institutions[1].id | https://openalex.org/I68947357 |
| authorships[0].institutions[1].ror | https://ror.org/00pg6eq24 |
| authorships[0].institutions[1].type | education |
| authorships[0].institutions[1].lineage | https://openalex.org/I68947357 |
| authorships[0].institutions[1].country_code | FR |
| authorships[0].institutions[1].display_name | Université de Strasbourg |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Andreas Tsouris |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Université de Strasbourg, CNRS GMGM UMR 7156 Strasbourg France |
| authorships[1].author.id | https://openalex.org/A5092538082 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Gauthier Brach |
| authorships[1].countries | FR |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I1294671590, https://openalex.org/I68947357 |
| authorships[1].affiliations[0].raw_affiliation_string | Université de Strasbourg, CNRS GMGM UMR 7156 Strasbourg France |
| authorships[1].institutions[0].id | https://openalex.org/I1294671590 |
| authorships[1].institutions[0].ror | https://ror.org/02feahw73 |
| authorships[1].institutions[0].type | government |
| authorships[1].institutions[0].lineage | https://openalex.org/I1294671590 |
| authorships[1].institutions[0].country_code | FR |
| authorships[1].institutions[0].display_name | Centre National de la Recherche Scientifique |
| authorships[1].institutions[1].id | https://openalex.org/I68947357 |
| authorships[1].institutions[1].ror | https://ror.org/00pg6eq24 |
| authorships[1].institutions[1].type | education |
| authorships[1].institutions[1].lineage | https://openalex.org/I68947357 |
| authorships[1].institutions[1].country_code | FR |
| authorships[1].institutions[1].display_name | Université de Strasbourg |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Gauthier Brach |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Université de Strasbourg, CNRS GMGM UMR 7156 Strasbourg France |
| authorships[2].author.id | https://openalex.org/A5051713747 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-3558-9356 |
| authorships[2].author.display_name | Anne Friedrich |
| authorships[2].countries | FR |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I1294671590, https://openalex.org/I68947357 |
| authorships[2].affiliations[0].raw_affiliation_string | Université de Strasbourg, CNRS GMGM UMR 7156 Strasbourg France |
| authorships[2].institutions[0].id | https://openalex.org/I1294671590 |
| authorships[2].institutions[0].ror | https://ror.org/02feahw73 |
| authorships[2].institutions[0].type | government |
| authorships[2].institutions[0].lineage | https://openalex.org/I1294671590 |
| authorships[2].institutions[0].country_code | FR |
| authorships[2].institutions[0].display_name | Centre National de la Recherche Scientifique |
| authorships[2].institutions[1].id | https://openalex.org/I68947357 |
| authorships[2].institutions[1].ror | https://ror.org/00pg6eq24 |
| authorships[2].institutions[1].type | education |
| authorships[2].institutions[1].lineage | https://openalex.org/I68947357 |
| authorships[2].institutions[1].country_code | FR |
| authorships[2].institutions[1].display_name | Université de Strasbourg |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Anne Friedrich |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Université de Strasbourg, CNRS GMGM UMR 7156 Strasbourg France |
| authorships[3].author.id | https://openalex.org/A5078140086 |
| authorships[3].author.orcid | https://orcid.org/0000-0003-2940-9670 |
| authorships[3].author.display_name | Jing Hou |
| authorships[3].countries | FR |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I1294671590, https://openalex.org/I68947357 |
| authorships[3].affiliations[0].raw_affiliation_string | Université de Strasbourg, CNRS GMGM UMR 7156 Strasbourg France |
| authorships[3].institutions[0].id | https://openalex.org/I1294671590 |
| authorships[3].institutions[0].ror | https://ror.org/02feahw73 |
| authorships[3].institutions[0].type | government |
| authorships[3].institutions[0].lineage | https://openalex.org/I1294671590 |
| authorships[3].institutions[0].country_code | FR |
| authorships[3].institutions[0].display_name | Centre National de la Recherche Scientifique |
| authorships[3].institutions[1].id | https://openalex.org/I68947357 |
| authorships[3].institutions[1].ror | https://ror.org/00pg6eq24 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I68947357 |
| authorships[3].institutions[1].country_code | FR |
| authorships[3].institutions[1].display_name | Université de Strasbourg |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Jing Hou |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Université de Strasbourg, CNRS GMGM UMR 7156 Strasbourg France |
| authorships[4].author.id | https://openalex.org/A5091722749 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-6606-6884 |
| authorships[4].author.display_name | Joseph Schacherer |
| authorships[4].countries | FR |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I1294671590, https://openalex.org/I68947357 |
| authorships[4].affiliations[0].raw_affiliation_string | Université de Strasbourg, CNRS GMGM UMR 7156 Strasbourg France |
| authorships[4].affiliations[1].institution_ids | https://openalex.org/I185839726 |
| authorships[4].affiliations[1].raw_affiliation_string | Institut Universitaire de France (IUF) Paris France |
| authorships[4].institutions[0].id | https://openalex.org/I1294671590 |
| authorships[4].institutions[0].ror | https://ror.org/02feahw73 |
| authorships[4].institutions[0].type | government |
| authorships[4].institutions[0].lineage | https://openalex.org/I1294671590 |
| authorships[4].institutions[0].country_code | FR |
| authorships[4].institutions[0].display_name | Centre National de la Recherche Scientifique |
| authorships[4].institutions[1].id | https://openalex.org/I185839726 |
| authorships[4].institutions[1].ror | https://ror.org/055khg266 |
| authorships[4].institutions[1].type | education |
| authorships[4].institutions[1].lineage | https://openalex.org/I185839726 |
| authorships[4].institutions[1].country_code | FR |
| authorships[4].institutions[1].display_name | Institut Universitaire de France |
| authorships[4].institutions[2].id | https://openalex.org/I68947357 |
| authorships[4].institutions[2].ror | https://ror.org/00pg6eq24 |
| authorships[4].institutions[2].type | education |
| authorships[4].institutions[2].lineage | https://openalex.org/I68947357 |
| authorships[4].institutions[2].country_code | FR |
| authorships[4].institutions[2].display_name | Université de Strasbourg |
| authorships[4].author_position | last |
| authorships[4].raw_author_name | Joseph Schacherer |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Institut Universitaire de France (IUF) Paris France, Université de Strasbourg, CNRS GMGM UMR 7156 Strasbourg France |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.1038/s44320-024-00021-0 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Diallel panel reveals a significant impact of low-frequency genetic variants on gene expression variation in yeast |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-23T05:10:03.516525 |
| primary_topic.id | https://openalex.org/T11468 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.998199999332428 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1311 |
| primary_topic.subfield.display_name | Genetics |
| primary_topic.display_name | Genetic Mapping and Diversity in Plants and Animals |
| related_works | https://openalex.org/W1999277182, https://openalex.org/W2558794025, https://openalex.org/W2594299395, https://openalex.org/W2066467839, https://openalex.org/W2111842731, https://openalex.org/W2170506381, https://openalex.org/W2765794416, https://openalex.org/W2039666944, https://openalex.org/W4385824058, https://openalex.org/W325781193 |
| cited_by_count | 5 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 2 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 2 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 1 |
| locations_count | 5 |
| best_oa_location.id | doi:10.1038/s44320-024-00021-0 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S200893805 |
| best_oa_location.source.issn | 1744-4292 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1744-4292 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Molecular Systems Biology |
| best_oa_location.source.host_organization | https://openalex.org/P4310319965 |
| best_oa_location.source.host_organization_name | Springer Nature |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310319965 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Molecular Systems Biology |
| best_oa_location.landing_page_url | https://doi.org/10.1038/s44320-024-00021-0 |
| primary_location.id | doi:10.1038/s44320-024-00021-0 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S200893805 |
| primary_location.source.issn | 1744-4292 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1744-4292 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Molecular Systems Biology |
| primary_location.source.host_organization | https://openalex.org/P4310319965 |
| primary_location.source.host_organization_name | Springer Nature |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310319965 |
| primary_location.license | cc-by |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Molecular Systems Biology |
| primary_location.landing_page_url | https://doi.org/10.1038/s44320-024-00021-0 |
| publication_date | 2024-02-14 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W2975095072, https://openalex.org/W2765606673, https://openalex.org/W1993616000, https://openalex.org/W3036928921, https://openalex.org/W2144961623, https://openalex.org/W3166451588, https://openalex.org/W2982183508, https://openalex.org/W4377098371, https://openalex.org/W2099085143, https://openalex.org/W2949884285, https://openalex.org/W2106578986, https://openalex.org/W2063575312, https://openalex.org/W3131055609, https://openalex.org/W2169456326, https://openalex.org/W1975880030, https://openalex.org/W3085774086, https://openalex.org/W2982084346, https://openalex.org/W1978150238, https://openalex.org/W2153283265, https://openalex.org/W2761275051, https://openalex.org/W4376118380, https://openalex.org/W3107895757, https://openalex.org/W2117446594, https://openalex.org/W2000008802, https://openalex.org/W2146341019, https://openalex.org/W2462490406, https://openalex.org/W4317502116, https://openalex.org/W2950680407, https://openalex.org/W2473818600, https://openalex.org/W2950354111, https://openalex.org/W4362661900, https://openalex.org/W4376133202, https://openalex.org/W2138207763, https://openalex.org/W3134382222, https://openalex.org/W2126015874, https://openalex.org/W2080183225, https://openalex.org/W1980991473, https://openalex.org/W2584469054, https://openalex.org/W4224291468, https://openalex.org/W3007056153, https://openalex.org/W4385415902, https://openalex.org/W2976098430, https://openalex.org/W2798064943, https://openalex.org/W2129559300, https://openalex.org/W2040912377, https://openalex.org/W2112991137, https://openalex.org/W1532903423, https://openalex.org/W2118308505, https://openalex.org/W3199243760, https://openalex.org/W4391128077, https://openalex.org/W4389305331, https://openalex.org/W2725988230, https://openalex.org/W1577746698, https://openalex.org/W4220827000, https://openalex.org/W1907868928, https://openalex.org/W1973067702, https://openalex.org/W2127801899, https://openalex.org/W1993317161, https://openalex.org/W4282973751, https://openalex.org/W3181602837, https://openalex.org/W2056927191, https://openalex.org/W2110808585, https://openalex.org/W4398210223 |
| referenced_works_count | 63 |
| abstract_inverted_index.a | 72, 138, 165 |
| abstract_inverted_index.26 | 84 |
| abstract_inverted_index.In | 43 |
| abstract_inverted_index.To | 59 |
| abstract_inverted_index.an | 97, 143 |
| abstract_inverted_index.as | 47 |
| abstract_inverted_index.at | 171 |
| abstract_inverted_index.in | 19, 30, 56 |
| abstract_inverted_index.is | 9 |
| abstract_inverted_index.of | 5, 16, 27, 40, 63, 76, 83, 100, 116, 145, 157, 161, 168 |
| abstract_inverted_index.on | 66 |
| abstract_inverted_index.to | 11, 149 |
| abstract_inverted_index.we | 70, 95, 119 |
| abstract_inverted_index.323 | 77 |
| abstract_inverted_index.SVs | 106, 124, 131 |
| abstract_inverted_index.all | 117 |
| abstract_inverted_index.and | 49, 91, 105, 123 |
| abstract_inverted_index.are | 53 |
| abstract_inverted_index.for | 107 |
| abstract_inverted_index.the | 2, 14, 41, 61, 114, 155, 159, 172 |
| abstract_inverted_index.SNPs | 122, 136 |
| abstract_inverted_index.from | 80 |
| abstract_inverted_index.gene | 6, 31, 67, 127, 133 |
| abstract_inverted_index.only | 37 |
| abstract_inverted_index.part | 39 |
| abstract_inverted_index.size | 141 |
| abstract_inverted_index.such | 46 |
| abstract_inverted_index.this | 108, 111 |
| abstract_inverted_index.with | 113, 126, 142, 164 |
| abstract_inverted_index.(SVs) | 52 |
| abstract_inverted_index.These | 152 |
| abstract_inverted_index.Using | 89 |
| abstract_inverted_index.While | 130 |
| abstract_inverted_index.fact, | 44 |
| abstract_inverted_index.ones. | 151 |
| abstract_inverted_index.panel | 74 |
| abstract_inverted_index.these | 64 |
| abstract_inverted_index.(SNPs) | 104 |
| abstract_inverted_index.assess | 60 |
| abstract_inverted_index.better | 12 |
| abstract_inverted_index.common | 150 |
| abstract_inverted_index.effect | 140 |
| abstract_inverted_index.higher | 139 |
| abstract_inverted_index.impact | 62, 132 |
| abstract_inverted_index.level. | 174 |
| abstract_inverted_index.mapped | 121 |
| abstract_inverted_index.panel. | 109 |
| abstract_inverted_index.poorly | 54 |
| abstract_inverted_index.short- | 90 |
| abstract_inverted_index.single | 101 |
| abstract_inverted_index.traits | 163 |
| abstract_inverted_index.catalog | 99, 167 |
| abstract_inverted_index.complex | 162 |
| abstract_inverted_index.crosses | 82 |
| abstract_inverted_index.dataset | 112 |
| abstract_inverted_index.exhibit | 137 |
| abstract_inverted_index.explain | 38 |
| abstract_inverted_index.genetic | 3, 169 |
| abstract_inverted_index.hybrids | 78 |
| abstract_inverted_index.natural | 20, 85 |
| abstract_inverted_index.origins | 15 |
| abstract_inverted_index.results | 153 |
| abstract_inverted_index.sources | 4 |
| abstract_inverted_index.studies | 24 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.captured | 55 |
| abstract_inverted_index.compared | 148 |
| abstract_inverted_index.composed | 75 |
| abstract_inverted_index.detected | 36 |
| abstract_inverted_index.explored | 71 |
| abstract_inverted_index.however, | 34 |
| abstract_inverted_index.hybrids, | 118 |
| abstract_inverted_index.involved | 29 |
| abstract_inverted_index.pairwise | 81 |
| abstract_inverted_index.studies. | 58 |
| abstract_inverted_index.variants | 28, 35, 45, 51, 65, 147, 170 |
| abstract_inverted_index.Combining | 110 |
| abstract_inverted_index.diversity | 18 |
| abstract_inverted_index.essential | 10 |
| abstract_inverted_index.isolates. | 88 |
| abstract_inverted_index.long-read | 92 |
| abstract_inverted_index.reinforce | 154 |
| abstract_inverted_index.thousands | 26 |
| abstract_inverted_index.variation | 8 |
| abstract_inverted_index.Unraveling | 1 |
| abstract_inverted_index.associated | 125 |
| abstract_inverted_index.cerevisiae | 87 |
| abstract_inverted_index.dissecting | 158 |
| abstract_inverted_index.exhaustive | 98 |
| abstract_inverted_index.expression | 7, 32, 68, 128, 134 |
| abstract_inverted_index.identified | 25 |
| abstract_inverted_index.importance | 156 |
| abstract_inverted_index.nucleotide | 102 |
| abstract_inverted_index.originated | 79 |
| abstract_inverted_index.phenotypic | 17 |
| abstract_inverted_index.population | 173 |
| abstract_inverted_index.sequencing | 93 |
| abstract_inverted_index.structural | 50 |
| abstract_inverted_index.understand | 13 |
| abstract_inverted_index.variation, | 33, 69, 135 |
| abstract_inverted_index.variation. | 129 |
| abstract_inverted_index.Genome-wide | 22 |
| abstract_inverted_index.association | 23, 57 |
| abstract_inverted_index.established | 96 |
| abstract_inverted_index.strategies, | 94 |
| abstract_inverted_index.half-diallel | 73 |
| abstract_inverted_index.heritability | 160 |
| abstract_inverted_index.populations. | 21 |
| abstract_inverted_index.Saccharomyces | 86 |
| abstract_inverted_index.comprehensive | 166 |
| abstract_inverted_index.heritability. | 42 |
| abstract_inverted_index.low-frequency | 48, 146 |
| abstract_inverted_index.polymorphisms | 103 |
| abstract_inverted_index.transcriptomes | 115 |
| abstract_inverted_index.comprehensively | 120 |
| abstract_inverted_index.overrepresentation | 144 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 89 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 5 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/15 |
| sustainable_development_goals[0].score | 0.41999998688697815 |
| sustainable_development_goals[0].display_name | Life in Land |
| citation_normalized_percentile.value | 0.89265058 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |