Diet-derived metabolites and mucus link the gut microbiome to fever after cytotoxic cancer treatment Article Swipe

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Zaker Schwabkey , Diana H. Wiesnoski , Chia‐Chi Chang , Wen-Bin Tsai , Dung Pham , Saira Ahmed , Tomo Hayase , Miriam R. Ortega Turrubiates , Rawan K. El-Himri , Christopher A. Sanchez , Eiko Hayase , Annette C. Frenk Oquendo , Takahiko Miyama , Taylor M. Halsey , Brooke E. Heckel , Alexandria Brown , Yimei Jin , Philip L. Lorenzi , Marc O. Warmoes , Lin Tan , Alton G. Swennes , V. Behrana Jensen , Christine B. Peterson , Kim‐Anh Do , Liangliang Zhang , Yushu Shi , Yinghong Wang , Jessica Galloway-Peña , Pablo C. Okhuysen , Carrie R. Daniel , Yusuke Shono , Marina Burgos da Silva , Jonathan U. Peled , Marcel R.M. van den Brink , Nadim J. Ajami , Jennifer A. Wargo , Gabriela Rondón , Samer A. Srour , Rohtesh S. Mehta , Amin M. Alousi , Elizabeth J. Shpall , Richard E. Champlin , Samuel A. Shelburne , Jeffrey J. Molldrem , Mohamed A. Jamal , Jennifer Karmouch , Robert R. Jenq ·

YOU? · · 2021 · Open Access · · DOI: https://doi.org/10.1101/2021.09.18.460647

Not all cancer patients with severe neutropenia develop fever, and the fecal microbiome may play a role. In neutropenic hematopoietic cell transplant patients (n=119), 63 (53%) developed a subsequent fever and had increased fecal Akkermansia muciniphila , a mucus-degrading bacteria (p=0.006, corrected for multiple comparisons). In mouse models, two therapies, irradiation and melphalan, similarly expanded A. muciniphila . Dietary restriction of unirradiated mice also expanded A. muciniphila and thinned the colonic mucus layer. Azithromycin treatment depleted A. muciniphila and preserved colonic mucus. Dietary restriction raised colonic luminal pH and reduced acetate, propionate, and butyrate. Culturing A. muciniphila with lower pH and increased propionate prevented utilization of mucin. Treating irradiated mice with azithromycin or propionate preserved the mucus layer, lessened hypothermia, and reduced inflammatory cytokines in the colon. These results suggest that diet, metabolites and colonic mucus link the microbiome to neutropenic fever, and could guide future microbiome-based preventive strategies.

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Akkermansia muciniphila Mucus Microbiome Mucin Microbiology Azithromycin Feces Biology Butyrate Immunology Gut flora Medicine Gastroenterology Antibiotics Biochemistry Bioinformatics Ecology Fermentation

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Type: preprint
Language: en
Landing Page: https://doi.org/10.1101/2021.09.18.460647
PDF: https://www.biorxiv.org/content/biorxiv/early/2021/09/18/2021.09.18.460647.full.pdf
OA Status: green
Cited By: 3
References: 60
Related Works: 10
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DOI: https://doi.org/10.1101/2021.09.18.460647

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Title: Diet-derived metabolites and mucus link the gut microbiome to fever after cytotoxic cancer treatment

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Type: preprint

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Language: en

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Publication year: 2021

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Publication date: 2021-09-18

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Authors: Zaker Schwabkey, Diana H. Wiesnoski, Chia‐Chi Chang, Wen-Bin Tsai, Dung Pham, Saira Ahmed, Tomo Hayase, Miriam R. Ortega Turrubiates, Rawan K. El-Himri, Christopher A. Sanchez, Eiko Hayase, Annette C. Frenk Oquendo, Takahiko Miyama, Taylor M. Halsey, Brooke E. Heckel, Alexandria Brown, Yimei Jin, Philip L. Lorenzi, Marc O. Warmoes, Lin Tan, Alton G. Swennes, V. Behrana Jensen, Christine B. Peterson, Kim‐Anh Do, Liangliang Zhang, Yushu Shi, Yinghong Wang, Jessica Galloway-Peña, Pablo C. Okhuysen, Carrie R. Daniel, Yusuke Shono, Marina Burgos da Silva, Jonathan U. Peled, Marcel R.M. van den Brink, Nadim J. Ajami, Jennifer A. Wargo, Gabriela Rondón, Samer A. Srour, Rohtesh S. Mehta, Amin M. Alousi, Elizabeth J. Shpall, Richard E. Champlin, Samuel A. Shelburne, Jeffrey J. Molldrem, Mohamed A. Jamal, Jennifer Karmouch, Robert R. Jenq

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Landing page: https://doi.org/10.1101/2021.09.18.460647

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PDF URL: https://www.biorxiv.org/content/biorxiv/early/2021/09/18/2021.09.18.460647.full.pdf

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Concepts: Akkermansia muciniphila, Mucus, Microbiome, Mucin, Microbiology, Azithromycin, Feces, Biology, Butyrate, Immunology, Gut flora, Medicine, Gastroenterology, Antibiotics, Biochemistry, Bioinformatics, Ecology, Fermentation

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Cited by: 3

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