Dietary Phosphorus, Its Sources, and Mortality in Adults on Haemodialysis: The DIET-HD Study Article Swipe
YOU?
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· 2022
· Open Access
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· DOI: https://doi.org/10.3390/nu14194064
Dietary phosphorus restrictions are usually recommended for people on haemodialysis, although its impact on patient-relevant outcomes is uncertain. We aimed to evaluate the association between total phosphorus intake and its sources with mortality in haemodialysis. Phosphorus intake was ascertained within the DIET-HD study in 8110 adults on haemodialysis. Adjusted Cox regression analyses were conducted to evaluate the association between the total and source-specific phosphorus (plant-, animal-, or processed and other sources) with mortality. During a median 3.8 years of follow-up, there were 2953 deaths, 1160 cardiovascular-related. The median phosphorus intake was 1388 mg/day. Every standard deviation (SD) (896 mg/day) increase in total phosphorus was associated with higher all-cause mortality [hazard ratio (HR), 1.16; 95% confidence intervals (CI), 1.06–1.26] and cardiovascular mortality (HR, 1.18; 95% CI, 1.03–1.36). Every SD (17%) increase in the proportion of phosphorus from plant sources was associated with lower all-cause mortality (HR, 0.95; 95% CI, 0.90–0.99). Every SD (9%) increase in the proportion of phosphorus from the processed and other sources was associated with higher all-cause mortality (HR, 1.06; 95% CI, 1.02–1.10). A higher total phosphorus intake was associated with increased all-cause and cardiovascular death. This association is driven largely by the phosphorus intake from processed food. Plant based phosphorus was associated with lower all-cause mortality.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/nu14194064
- https://www.mdpi.com/2072-6643/14/19/4064/pdf?version=1664517616
- OA Status
- gold
- Cited By
- 8
- References
- 30
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4303962263
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4303962263Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/nu14194064Digital Object Identifier
- Title
-
Dietary Phosphorus, Its Sources, and Mortality in Adults on Haemodialysis: The DIET-HD StudyWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-09-30Full publication date if available
- Authors
-
Guobin Su, Valeria Saglimbene, Germaine Wong, Amélie Bernier-Jean, Juan Jesús Carrero, Patrizia Natale, Marinella Ruospo, Jörgen Hegbrant, Jonathan C. Craig, Giovanni FM StrippoliList of authors in order
- Landing page
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https://doi.org/10.3390/nu14194064Publisher landing page
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https://www.mdpi.com/2072-6643/14/19/4064/pdf?version=1664517616Direct link to full text PDF
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/2072-6643/14/19/4064/pdf?version=1664517616Direct OA link when available
- Concepts
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Phosphorus, Medicine, Internal medicine, Physiology, Food science, Biology, Chemistry, Organic chemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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8Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 4, 2023: 1Per-year citation counts (last 5 years)
- References (count)
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30Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.higher | 106, 167, 176 |
| abstract_inverted_index.impact | 12 |
| abstract_inverted_index.intake | 27, 36, 89, 179, 196 |
| abstract_inverted_index.median | 75, 87 |
| abstract_inverted_index.people | 7 |
| abstract_inverted_index.within | 39 |
| abstract_inverted_index.DIET-HD | 41 |
| abstract_inverted_index.Dietary | 0 |
| abstract_inverted_index.[hazard | 109 |
| abstract_inverted_index.between | 24, 58 |
| abstract_inverted_index.deaths, | 83 |
| abstract_inverted_index.largely | 192 |
| abstract_inverted_index.mg/day) | 98 |
| abstract_inverted_index.mg/day. | 92 |
| abstract_inverted_index.sources | 30, 137, 163 |
| abstract_inverted_index.usually | 4 |
| abstract_inverted_index.(plant-, | 64 |
| abstract_inverted_index.Adjusted | 48 |
| abstract_inverted_index.although | 10 |
| abstract_inverted_index.analyses | 51 |
| abstract_inverted_index.animal-, | 65 |
| abstract_inverted_index.evaluate | 21, 55 |
| abstract_inverted_index.increase | 99, 129, 152 |
| abstract_inverted_index.outcomes | 15 |
| abstract_inverted_index.sources) | 70 |
| abstract_inverted_index.standard | 94 |
| abstract_inverted_index.all-cause | 107, 142, 168, 184, 207 |
| abstract_inverted_index.conducted | 53 |
| abstract_inverted_index.deviation | 95 |
| abstract_inverted_index.increased | 183 |
| abstract_inverted_index.intervals | 115 |
| abstract_inverted_index.mortality | 32, 108, 120, 143, 169 |
| abstract_inverted_index.processed | 67, 160, 198 |
| abstract_inverted_index.Phosphorus | 35 |
| abstract_inverted_index.associated | 104, 139, 165, 181, 204 |
| abstract_inverted_index.confidence | 114 |
| abstract_inverted_index.follow-up, | 79 |
| abstract_inverted_index.mortality. | 72, 208 |
| abstract_inverted_index.phosphorus | 1, 26, 63, 88, 102, 134, 157, 178, 195, 202 |
| abstract_inverted_index.proportion | 132, 155 |
| abstract_inverted_index.regression | 50 |
| abstract_inverted_index.uncertain. | 17 |
| abstract_inverted_index.ascertained | 38 |
| abstract_inverted_index.association | 23, 57, 189 |
| abstract_inverted_index.recommended | 5 |
| abstract_inverted_index.1.06–1.26] | 117 |
| abstract_inverted_index.restrictions | 2 |
| abstract_inverted_index.0.90–0.99). | 148 |
| abstract_inverted_index.1.02–1.10). | 174 |
| abstract_inverted_index.1.03–1.36). | 125 |
| abstract_inverted_index.cardiovascular | 119, 186 |
| abstract_inverted_index.haemodialysis, | 9 |
| abstract_inverted_index.haemodialysis. | 34, 47 |
| abstract_inverted_index.source-specific | 62 |
| abstract_inverted_index.patient-relevant | 14 |
| abstract_inverted_index.cardiovascular-related. | 85 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5080193257 |
| countries_distinct_count | 5 |
| institutions_distinct_count | 10 |
| corresponding_institution_ids | https://openalex.org/I129604602, https://openalex.org/I5561750 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.6499999761581421 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.78192727 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |