Diethylcarbamazine elicits Ca 2+ signals through TRP-2 channels that are potentiated by emodepside in Brugia malayi muscles Article Swipe
Paul Williams
,
Sudhanva S. Kashyap
,
Alan P. Robertson
,
Richard J. Martin
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1128/aac.00419-23
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1128/aac.00419-23
Filarial nematode infections are a major health concern in several countries. Lymphatic filariasis is caused by Wuchereria bancrofti and Brugia spp. affecting over 120 million people. Heavy infections can lead to elephantiasis, which has serious effects on individuals’ lives. Although current anthelmintics are effective at killing microfilariae in the bloodstream, they have little to no effect against adult parasites found in the lymphatic system. The anthelmintic diethylcarbamazine is one of the central pillars of lymphatic filariasis control. Recent studies have reported that diethylcarbamazine can open transient receptor potential (TRP) channels in the muscles of adult female Brugia malayi, leading to contraction and paralysis. Diethylcarbamazine has synergistic effects in combination with emodepside on Brugia, inhibiting motility: emodepside is an anthelmintic that has effects on filarial nematodes and is under trial for the treatment of river blindness. Here, we have studied the effects of diethylcarbamazine on single Brugia muscle cells by measuring the change in Ca 2+ fluorescence in the muscle using Ca 2+ -imaging techniques. Diethylcarbamazine interacts with the transient receptor potential channel, C classification (TRPC) ortholog receptor TRP-2 to promote Ca 2+ entry into the Brugia muscle cells, which can activate Slopoke (SLO-1) Ca 2+ -activated K + channels, the putative target of emodepside. A combination of diethylcarbamazine and emodepside leads to a bigger Ca 2+ signal than when either compound is applied alone. Our study shows that diethylcarbamazine targets TRP channels to promote Ca 2+ entry that is increased by emodepside activation of SLO-1 K + channels.
Related Topics
Concepts
Diethylcarbamazine
Brugia malayi
Lymphatic filariasis
Anthelmintic
Biology
Brugia pahangi
Wuchereria bancrofti
Transient receptor potential channel
Filariasis
Pharmacology
Immunology
Receptor
Helminths
Ecology
Biochemistry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1128/aac.00419-23
- OA Status
- hybrid
- Cited By
- 4
- References
- 37
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4386887067
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4386887067Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1128/aac.00419-23Digital Object Identifier
- Title
-
Diethylcarbamazine elicits Ca 2+ signals through TRP-2 channels that are potentiated by emodepside in Brugia malayi musclesWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-09-20Full publication date if available
- Authors
-
Paul Williams, Sudhanva S. Kashyap, Alan P. Robertson, Richard J. MartinList of authors in order
- Landing page
-
https://doi.org/10.1128/aac.00419-23Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1128/aac.00419-23Direct OA link when available
- Concepts
-
Diethylcarbamazine, Brugia malayi, Lymphatic filariasis, Anthelmintic, Biology, Brugia pahangi, Wuchereria bancrofti, Transient receptor potential channel, Filariasis, Pharmacology, Immunology, Receptor, Helminths, Ecology, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
4Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 2Per-year citation counts (last 5 years)
- References (count)
-
37Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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