Differences in the gut microbiomes of distinct ethnicities within the same geographic area are linked to host metabolic health Article Swipe
Qi Yan Ang
,
Diana Alba
,
Vaibhav Upadhyay
,
Jordan E. Bisanz
,
Jingwei Cai
,
Ho Lim Lee
,
Eliseo Barajas
,
Grace Wei
,
Cecilia Noecker
,
Andrew D. Patterson
,
Suneil K. Koliwad
,
Peter J. Turnbaugh
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-100084/v2
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-100084/v2
Background: The human gut microbiota exhibits marked variation around the world, which has been attributed to dietary intake and other environmental factors. However, the degree to which ethnicity-associated differences in gut microbial community structure and function are maintained following immigration or in the context of metabolic disease is poorly understood. Results: We conducted a multi-omic study of 46 lean and obese East Asian and White participants living in the San Francisco Bay Area. 16S rRNA gene sequencing revealed significant differences between ethnic groups in bacterial richness and community structure. White individuals were enriched for the mucin-degrading Akkermansia muciniphila. East Asian participants had increased levels of multiple bacterial phyla, fermentative pathways detected by metagenomics, and the short-chain fatty acid end products acetate, propionate, and isobutyrate. Differences in the gut microbiota between the East Asian and White groups could not be explained by reported dietary intake, were more pronounced in lean individuals, and were associated with current geographical location. Microbiome transplantations into germ-free mice confirmed that the differences in the gut microbiota of the East Asian and White individuals we analyzed are independent of diet and that they differentially impact host body weight and adiposity in genetically identical mouse recipients. Conclusions: The reported findings emphasize the utility of studying diverse ethnic groups within a defined geographical location and provide a starting point for dissecting the mechanisms contributing to the complex interactions between the gut microbiome and ethnicity-associated lifestyle, demographic, metabolic, and genetic factors.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-100084/v2
- https://www.researchsquare.com/article/rs-100084/latest.pdf
- OA Status
- green
- References
- 80
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4249610115
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4249610115Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21203/rs.3.rs-100084/v2Digital Object Identifier
- Title
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Differences in the gut microbiomes of distinct ethnicities within the same geographic area are linked to host metabolic healthWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-03-22Full publication date if available
- Authors
-
Qi Yan Ang, Diana Alba, Vaibhav Upadhyay, Jordan E. Bisanz, Jingwei Cai, Ho Lim Lee, Eliseo Barajas, Grace Wei, Cecilia Noecker, Andrew D. Patterson, Suneil K. Koliwad, Peter J. TurnbaughList of authors in order
- Landing page
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https://doi.org/10.21203/rs.3.rs-100084/v2Publisher landing page
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https://www.researchsquare.com/article/rs-100084/latest.pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.researchsquare.com/article/rs-100084/latest.pdfDirect OA link when available
- Concepts
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Host (biology), Ethnic group, Microbiome, Gut microbiome, Biology, Evolutionary biology, Genetics, Sociology, AnthropologyTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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80Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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