Different Expression Pattern of G Protein-Coupled Estrogen Receptor GPER1 in Esophageal Squamous Cell Carcinoma and Adenocarcinoma Article Swipe
Jingshi Liu
,
Yongdong Niu
,
Bin Zhang
,
Qisi Sun
,
Haiyi Li
,
Lu Bai
,
Zhongjing Su
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/ijms241814055
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/ijms241814055
Esophageal carcinoma is a male-dominant malignancy worldwide, and esophageal adenocarcinoma (EAC) shows more significant sex bias than esophageal squamous cell carcinoma (ESCC) in morbidity and mortality. The G protein-coupled estrogen receptor 1 (GPER1) is involved in several sex-related cancers; however, its expression level in esophageal carcinoma has been poorly investigated and its role is not precisely defined, depending on histological types. In the present study, the mRNA levels of GPER1 in esophageal carcinoma were collected from GEPIA and Oncomine databases for meta-analyses. The protein expression levels of GPER1 were detected by immunohistochemistry in the tissue microarray of EAC and ESCC. The GPER1 selective agonist G1, antagonist G15, and siRNA were applied in vitro to investigate their impacts on esophageal cell lines. Analysis of the RNA levels from the databases showed a decreased expression of GPER1 in overall esophageal carcinoma, and low expression levels of GPER1 were found to be associated with low survival of tumor patients. However, in the subgroup of EAC and its precancerous lesion, Barrett’s esophagus, overexpression of GPER1 RNA was increased when compared with the normal tissues. The average staining scores of GPER1 protein in the tissue microarray of EAC were significantly higher than normal esophageal samples, and the rate of positive staining increased with the grade of poor tumor differentiation. The scores of GPER1 protein in ESCC tissues were lower than those in the normal tissues. The results from cell line experiments in vitro showed that the GPER1 agonist G1 inhibited proliferation and promoted apoptosis of ESCC cells EC109 with positive expression of GPER1. G1 had no obvious effect on normal esophageal NE2 cells with weak expression of GPER1. In addition, GPER1 RNA knockdown and application of antagonist G15 reversed the effects of G1 on EC109. The results of this study indicate that the expression levels of GPER1 are higher in EAC than in ESCC, which might be correlated with the dimorphic estrogen signaling pathway in different types of esophageal carcinoma.
Related Topics
Concepts
Estrogen receptor
Esophageal squamous cell carcinoma
Protein expression
Estrogen
Cancer research
Adenocarcinoma
Squamous carcinoma
Basal cell
Oncology
Esophageal adenocarcinoma
Carcinoma
Internal medicine
Biology
Medicine
Breast cancer
Cancer
Gene
Biochemistry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms241814055
- https://www.mdpi.com/1422-0067/24/18/14055/pdf?version=1694674356
- OA Status
- gold
- Cited By
- 1
- References
- 57
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4386747564
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4386747564Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/ijms241814055Digital Object Identifier
- Title
-
Different Expression Pattern of G Protein-Coupled Estrogen Receptor GPER1 in Esophageal Squamous Cell Carcinoma and AdenocarcinomaWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-09-13Full publication date if available
- Authors
-
Jingshi Liu, Yongdong Niu, Bin Zhang, Qisi Sun, Haiyi Li, Lu Bai, Zhongjing SuList of authors in order
- Landing page
-
https://doi.org/10.3390/ijms241814055Publisher landing page
- PDF URL
-
https://www.mdpi.com/1422-0067/24/18/14055/pdf?version=1694674356Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/1422-0067/24/18/14055/pdf?version=1694674356Direct OA link when available
- Concepts
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Estrogen receptor, Esophageal squamous cell carcinoma, Protein expression, Estrogen, Cancer research, Adenocarcinoma, Squamous carcinoma, Basal cell, Oncology, Esophageal adenocarcinoma, Carcinoma, Internal medicine, Biology, Medicine, Breast cancer, Cancer, Gene, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
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2024: 1Per-year citation counts (last 5 years)
- References (count)
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57Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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