Different Toxicity Profiles Predict Third Line Treatment Efficacy in Metastatic Colorectal Cancer Patients Article Swipe
Matthias Unseld
,
Sebastian Fischöder
,
Mathias Jachs
,
Magdalena Drimmel
,
Alexander Siebenhüner
,
Daniela Bianconi
,
Markus Kieler
,
Hannah Christina Puhr
,
Christoph Minichsdorfer
,
Thomas Winder
,
Gerald W. Prager
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/jcm9061772
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/jcm9061772
The nucleoside trifluridine/tipiracil (TAS-102) and the multikinase inhibitor regorafenib significantly improved survival in metastatic colorectal cancer patients (mCRC). Both treatments are characterized by different treatment-related adverse events but detailed analyses of predictive side effects are rare. In this retrospective, observational, real-life study, clinical data on mCRC patients treated with trifluridine/tipiracil or regorafenib at the Medical University of Vienna, Austria and the University Hospital Zurich, Switzerland were collected. The correlation between adverse events and response or survival rates were calculated performing Fisher’s exact test and log-rank test, respectively. Common adverse events of any grade included fatigue (52%), nausea/vertigo (34%), anemia (26%), and leukopenia (22%) in trifluridine/tipiracil patients and fatigue (42%), hand-foot-skin syndrome (36%) and hoarseness (34%) in patients upon regorafenib treatment. In trifluridine/tipiracil patients the prevalence of leukopenia (p = 0.044) and weight loss (p = 0.044) was prognostic, whereas leukopenia (p = 0.044) and neutropenia (p = 0.043) predicted PFS. The disease control rate was not significantly affected. In regorafenib-treated patients, the prevalence of nausea (p = 0.001) was prognostic, while oral mucositis predicted PFS (p = 0.032) as well as the DCR (p = 0.039). In conclusion, we underline the efficacy of trifluridine/tipiracil and regorafenib in the real-life setting. We describe predictive adverse events like neutropenia/leukopenia, which might be used as surrogate marker in anticancer therapy beyond second line treatment.
Related Topics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/jcm9061772
- https://www.mdpi.com/2077-0383/9/6/1772/pdf?version=1592910837
- OA Status
- gold
- Cited By
- 3
- References
- 24
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3033597420
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3033597420Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/jcm9061772Digital Object Identifier
- Title
-
Different Toxicity Profiles Predict Third Line Treatment Efficacy in Metastatic Colorectal Cancer PatientsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-06-07Full publication date if available
- Authors
-
Matthias Unseld, Sebastian Fischöder, Mathias Jachs, Magdalena Drimmel, Alexander Siebenhüner, Daniela Bianconi, Markus Kieler, Hannah Christina Puhr, Christoph Minichsdorfer, Thomas Winder, Gerald W. PragerList of authors in order
- Landing page
-
https://doi.org/10.3390/jcm9061772Publisher landing page
- PDF URL
-
https://www.mdpi.com/2077-0383/9/6/1772/pdf?version=1592910837Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2077-0383/9/6/1772/pdf?version=1592910837Direct OA link when available
- Concepts
-
Medicine, Colorectal cancer, Toxicity, Oncology, Internal medicine, CancerTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2023: 1, 2022: 1, 2020: 1Per-year citation counts (last 5 years)
- References (count)
-
24Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3033597420 |
|---|---|
| doi | https://doi.org/10.3390/jcm9061772 |
| ids.doi | https://doi.org/10.3390/jcm9061772 |
| ids.mag | 3033597420 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/32517383 |
| ids.openalex | https://openalex.org/W3033597420 |
| fwci | 0.30176336 |
| type | article |
| title | Different Toxicity Profiles Predict Third Line Treatment Efficacy in Metastatic Colorectal Cancer Patients |
| biblio.issue | 6 |
| biblio.volume | 9 |
| biblio.last_page | 1772 |
| biblio.first_page | 1772 |
| topics[0].id | https://openalex.org/T11067 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2730 |
| topics[0].subfield.display_name | Oncology |
| topics[0].display_name | Colorectal Cancer Treatments and Studies |
| topics[1].id | https://openalex.org/T10073 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9983999729156494 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2721 |
| topics[1].subfield.display_name | Hepatology |
| topics[1].display_name | Hepatocellular Carcinoma Treatment and Prognosis |
| topics[2].id | https://openalex.org/T10696 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9979000091552734 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2740 |
| topics[2].subfield.display_name | Pulmonary and Respiratory Medicine |
| topics[2].display_name | Gastric Cancer Management and Outcomes |
| is_xpac | False |
| apc_list.value | 2400 |
| apc_list.currency | CHF |
| apc_list.value_usd | 2598 |
| apc_paid.value | 2400 |
| apc_paid.currency | CHF |
| apc_paid.value_usd | 2598 |
| concepts[0].id | https://openalex.org/C71924100 |
| concepts[0].level | 0 |
| concepts[0].score | 0.98551344871521 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[0].display_name | Medicine |
| concepts[1].id | https://openalex.org/C526805850 |
| concepts[1].level | 3 |
| concepts[1].score | 0.7756378650665283 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q188874 |
| concepts[1].display_name | Colorectal cancer |
| concepts[2].id | https://openalex.org/C29730261 |
| concepts[2].level | 2 |
| concepts[2].score | 0.7023053765296936 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q274160 |
| concepts[2].display_name | Toxicity |
| concepts[3].id | https://openalex.org/C143998085 |
| concepts[3].level | 1 |
| concepts[3].score | 0.6329136490821838 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q162555 |
| concepts[3].display_name | Oncology |
| concepts[4].id | https://openalex.org/C126322002 |
| concepts[4].level | 1 |
| concepts[4].score | 0.5566895604133606 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[4].display_name | Internal medicine |
| concepts[5].id | https://openalex.org/C121608353 |
| concepts[5].level | 2 |
| concepts[5].score | 0.49723294377326965 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q12078 |
| concepts[5].display_name | Cancer |
| keywords[0].id | https://openalex.org/keywords/medicine |
| keywords[0].score | 0.98551344871521 |
| keywords[0].display_name | Medicine |
| keywords[1].id | https://openalex.org/keywords/colorectal-cancer |
| keywords[1].score | 0.7756378650665283 |
| keywords[1].display_name | Colorectal cancer |
| keywords[2].id | https://openalex.org/keywords/toxicity |
| keywords[2].score | 0.7023053765296936 |
| keywords[2].display_name | Toxicity |
| keywords[3].id | https://openalex.org/keywords/oncology |
| keywords[3].score | 0.6329136490821838 |
| keywords[3].display_name | Oncology |
| keywords[4].id | https://openalex.org/keywords/internal-medicine |
| keywords[4].score | 0.5566895604133606 |
| keywords[4].display_name | Internal medicine |
| keywords[5].id | https://openalex.org/keywords/cancer |
| keywords[5].score | 0.49723294377326965 |
| keywords[5].display_name | Cancer |
| language | en |
| locations[0].id | doi:10.3390/jcm9061772 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S2737969411 |
| locations[0].source.issn | 2077-0383 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2077-0383 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Journal of Clinical Medicine |
| locations[0].source.host_organization | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310310987 |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.mdpi.com/2077-0383/9/6/1772/pdf?version=1592910837 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Journal of Clinical Medicine |
| locations[0].landing_page_url | https://doi.org/10.3390/jcm9061772 |
| locations[1].id | pmid:32517383 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Journal of clinical medicine |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/32517383 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:7356853 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | J Clin Med |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/7356853 |
| locations[3].id | pmh:oai:mdpi.com:/2077-0383/9/6/1772/ |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S4306400947 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | True |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | MDPI (MDPI AG) |
| locations[3].source.host_organization | https://openalex.org/I4210097602 |
| locations[3].source.host_organization_name | Multidisciplinary Digital Publishing Institute (Switzerland) |
| locations[3].source.host_organization_lineage | https://openalex.org/I4210097602 |
| locations[3].license | cc-by |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/cc-by |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Journal of Clinical Medicine |
| locations[3].landing_page_url | http://dx.doi.org/10.3390/jcm9061772 |
| locations[4].id | pmh:oai:doaj.org/article:325ee93d3da7440fbf25c19c9afe1574 |
| locations[4].is_oa | True |
| locations[4].source.id | https://openalex.org/S4306401280 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[4].source.host_organization | |
| locations[4].source.host_organization_name | |
| locations[4].source.host_organization_lineage | |
| locations[4].license | cc-by-sa |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | article |
| locations[4].license_id | https://openalex.org/licenses/cc-by-sa |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | Journal of Clinical Medicine, Vol 9, Iss 1772, p 1772 (2020) |
| locations[4].landing_page_url | https://doaj.org/article/325ee93d3da7440fbf25c19c9afe1574 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5017933929 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-1699-9846 |
| authorships[0].author.display_name | Matthias Unseld |
| authorships[0].countries | AT |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I4210092129, https://openalex.org/I76134821 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Medicine I, Clin. Div. of Oncology, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria |
| authorships[0].institutions[0].id | https://openalex.org/I4210092129 |
| authorships[0].institutions[0].ror | https://ror.org/00df3z122 |
| authorships[0].institutions[0].type | healthcare |
| authorships[0].institutions[0].lineage | https://openalex.org/I2802328216, https://openalex.org/I4210092129 |
| authorships[0].institutions[0].country_code | AT |
| authorships[0].institutions[0].display_name | Comprehensive Cancer Center Vienna |
| authorships[0].institutions[1].id | https://openalex.org/I76134821 |
| authorships[0].institutions[1].ror | https://ror.org/05n3x4p02 |
| authorships[0].institutions[1].type | education |
| authorships[0].institutions[1].lineage | https://openalex.org/I76134821 |
| authorships[0].institutions[1].country_code | AT |
| authorships[0].institutions[1].display_name | Medical University of Vienna |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Matthias Unseld |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Medicine I, Clin. Div. of Oncology, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria |
| authorships[1].author.id | https://openalex.org/A5054198745 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Sebastian Fischöder |
| authorships[1].countries | AT |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I4210092129, https://openalex.org/I76134821 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Medicine I, Clin. Div. of Oncology, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria |
| authorships[1].institutions[0].id | https://openalex.org/I4210092129 |
| authorships[1].institutions[0].ror | https://ror.org/00df3z122 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I2802328216, https://openalex.org/I4210092129 |
| authorships[1].institutions[0].country_code | AT |
| authorships[1].institutions[0].display_name | Comprehensive Cancer Center Vienna |
| authorships[1].institutions[1].id | https://openalex.org/I76134821 |
| authorships[1].institutions[1].ror | https://ror.org/05n3x4p02 |
| authorships[1].institutions[1].type | education |
| authorships[1].institutions[1].lineage | https://openalex.org/I76134821 |
| authorships[1].institutions[1].country_code | AT |
| authorships[1].institutions[1].display_name | Medical University of Vienna |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Sebastian Fischöder |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Medicine I, Clin. Div. of Oncology, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria |
| authorships[2].author.id | https://openalex.org/A5080169213 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-2871-4147 |
| authorships[2].author.display_name | Mathias Jachs |
| authorships[2].countries | AT |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210092129, https://openalex.org/I76134821 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Medicine I, Clin. Div. of Oncology, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria |
| authorships[2].institutions[0].id | https://openalex.org/I4210092129 |
| authorships[2].institutions[0].ror | https://ror.org/00df3z122 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I2802328216, https://openalex.org/I4210092129 |
| authorships[2].institutions[0].country_code | AT |
| authorships[2].institutions[0].display_name | Comprehensive Cancer Center Vienna |
| authorships[2].institutions[1].id | https://openalex.org/I76134821 |
| authorships[2].institutions[1].ror | https://ror.org/05n3x4p02 |
| authorships[2].institutions[1].type | education |
| authorships[2].institutions[1].lineage | https://openalex.org/I76134821 |
| authorships[2].institutions[1].country_code | AT |
| authorships[2].institutions[1].display_name | Medical University of Vienna |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Mathias Jachs |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Medicine I, Clin. Div. of Oncology, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria |
| authorships[3].author.id | https://openalex.org/A5038609501 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Magdalena Drimmel |
| authorships[3].countries | AT |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I4210092129, https://openalex.org/I76134821 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Medicine I, Clin. Div. of Oncology, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria |
| authorships[3].institutions[0].id | https://openalex.org/I4210092129 |
| authorships[3].institutions[0].ror | https://ror.org/00df3z122 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I2802328216, https://openalex.org/I4210092129 |
| authorships[3].institutions[0].country_code | AT |
| authorships[3].institutions[0].display_name | Comprehensive Cancer Center Vienna |
| authorships[3].institutions[1].id | https://openalex.org/I76134821 |
| authorships[3].institutions[1].ror | https://ror.org/05n3x4p02 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I76134821 |
| authorships[3].institutions[1].country_code | AT |
| authorships[3].institutions[1].display_name | Medical University of Vienna |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Magdalena Drimmel |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Medicine I, Clin. Div. of Oncology, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria |
| authorships[4].author.id | https://openalex.org/A5108949519 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Alexander Siebenhüner |
| authorships[4].countries | CH |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I202697423, https://openalex.org/I4210100468 |
| authorships[4].affiliations[0].raw_affiliation_string | Clinic for Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, 8006 Zurich, Switzerland |
| authorships[4].institutions[0].id | https://openalex.org/I4210100468 |
| authorships[4].institutions[0].ror | https://ror.org/01462r250 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I4210100468 |
| authorships[4].institutions[0].country_code | CH |
| authorships[4].institutions[0].display_name | University Hospital of Zurich |
| authorships[4].institutions[1].id | https://openalex.org/I202697423 |
| authorships[4].institutions[1].ror | https://ror.org/02crff812 |
| authorships[4].institutions[1].type | education |
| authorships[4].institutions[1].lineage | https://openalex.org/I202697423 |
| authorships[4].institutions[1].country_code | CH |
| authorships[4].institutions[1].display_name | University of Zurich |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Alexander Siebenhüner |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Clinic for Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, 8006 Zurich, Switzerland |
| authorships[5].author.id | https://openalex.org/A5043085369 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-8102-4199 |
| authorships[5].author.display_name | Daniela Bianconi |
| authorships[5].countries | AT |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I4210092129, https://openalex.org/I76134821 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Medicine I, Clin. Div. of Oncology, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria |
| authorships[5].institutions[0].id | https://openalex.org/I4210092129 |
| authorships[5].institutions[0].ror | https://ror.org/00df3z122 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I2802328216, https://openalex.org/I4210092129 |
| authorships[5].institutions[0].country_code | AT |
| authorships[5].institutions[0].display_name | Comprehensive Cancer Center Vienna |
| authorships[5].institutions[1].id | https://openalex.org/I76134821 |
| authorships[5].institutions[1].ror | https://ror.org/05n3x4p02 |
| authorships[5].institutions[1].type | education |
| authorships[5].institutions[1].lineage | https://openalex.org/I76134821 |
| authorships[5].institutions[1].country_code | AT |
| authorships[5].institutions[1].display_name | Medical University of Vienna |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Daniela Bianconi |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Medicine I, Clin. Div. of Oncology, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria |
| authorships[6].author.id | https://openalex.org/A5056149600 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-4082-5731 |
| authorships[6].author.display_name | Markus Kieler |
| authorships[6].countries | AT |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I4210092129, https://openalex.org/I76134821 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Medicine I, Clin. Div. of Oncology, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria |
| authorships[6].institutions[0].id | https://openalex.org/I4210092129 |
| authorships[6].institutions[0].ror | https://ror.org/00df3z122 |
| authorships[6].institutions[0].type | healthcare |
| authorships[6].institutions[0].lineage | https://openalex.org/I2802328216, https://openalex.org/I4210092129 |
| authorships[6].institutions[0].country_code | AT |
| authorships[6].institutions[0].display_name | Comprehensive Cancer Center Vienna |
| authorships[6].institutions[1].id | https://openalex.org/I76134821 |
| authorships[6].institutions[1].ror | https://ror.org/05n3x4p02 |
| authorships[6].institutions[1].type | education |
| authorships[6].institutions[1].lineage | https://openalex.org/I76134821 |
| authorships[6].institutions[1].country_code | AT |
| authorships[6].institutions[1].display_name | Medical University of Vienna |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Markus Kieler |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Medicine I, Clin. Div. of Oncology, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria |
| authorships[7].author.id | https://openalex.org/A5091089536 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-7203-8732 |
| authorships[7].author.display_name | Hannah Christina Puhr |
| authorships[7].countries | AT |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I4210092129, https://openalex.org/I76134821 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Medicine I, Clin. Div. of Oncology, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria |
| authorships[7].institutions[0].id | https://openalex.org/I4210092129 |
| authorships[7].institutions[0].ror | https://ror.org/00df3z122 |
| authorships[7].institutions[0].type | healthcare |
| authorships[7].institutions[0].lineage | https://openalex.org/I2802328216, https://openalex.org/I4210092129 |
| authorships[7].institutions[0].country_code | AT |
| authorships[7].institutions[0].display_name | Comprehensive Cancer Center Vienna |
| authorships[7].institutions[1].id | https://openalex.org/I76134821 |
| authorships[7].institutions[1].ror | https://ror.org/05n3x4p02 |
| authorships[7].institutions[1].type | education |
| authorships[7].institutions[1].lineage | https://openalex.org/I76134821 |
| authorships[7].institutions[1].country_code | AT |
| authorships[7].institutions[1].display_name | Medical University of Vienna |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Hannah Puhr |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Medicine I, Clin. Div. of Oncology, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria |
| authorships[8].author.id | https://openalex.org/A5039578906 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-5455-9139 |
| authorships[8].author.display_name | Christoph Minichsdorfer |
| authorships[8].countries | AT |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I4210092129, https://openalex.org/I76134821 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Medicine I, Clin. Div. of Oncology, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria |
| authorships[8].institutions[0].id | https://openalex.org/I4210092129 |
| authorships[8].institutions[0].ror | https://ror.org/00df3z122 |
| authorships[8].institutions[0].type | healthcare |
| authorships[8].institutions[0].lineage | https://openalex.org/I2802328216, https://openalex.org/I4210092129 |
| authorships[8].institutions[0].country_code | AT |
| authorships[8].institutions[0].display_name | Comprehensive Cancer Center Vienna |
| authorships[8].institutions[1].id | https://openalex.org/I76134821 |
| authorships[8].institutions[1].ror | https://ror.org/05n3x4p02 |
| authorships[8].institutions[1].type | education |
| authorships[8].institutions[1].lineage | https://openalex.org/I76134821 |
| authorships[8].institutions[1].country_code | AT |
| authorships[8].institutions[1].display_name | Medical University of Vienna |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Christoph Minichsdorfer |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Medicine I, Clin. Div. of Oncology, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria |
| authorships[9].author.id | https://openalex.org/A5063566935 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-4216-2994 |
| authorships[9].author.display_name | Thomas Winder |
| authorships[9].countries | CH |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I202697423, https://openalex.org/I4210100468 |
| authorships[9].affiliations[0].raw_affiliation_string | Clinic for Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, 8006 Zurich, Switzerland |
| authorships[9].institutions[0].id | https://openalex.org/I4210100468 |
| authorships[9].institutions[0].ror | https://ror.org/01462r250 |
| authorships[9].institutions[0].type | healthcare |
| authorships[9].institutions[0].lineage | https://openalex.org/I4210100468 |
| authorships[9].institutions[0].country_code | CH |
| authorships[9].institutions[0].display_name | University Hospital of Zurich |
| authorships[9].institutions[1].id | https://openalex.org/I202697423 |
| authorships[9].institutions[1].ror | https://ror.org/02crff812 |
| authorships[9].institutions[1].type | education |
| authorships[9].institutions[1].lineage | https://openalex.org/I202697423 |
| authorships[9].institutions[1].country_code | CH |
| authorships[9].institutions[1].display_name | University of Zurich |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Thomas Winder |
| authorships[9].is_corresponding | True |
| authorships[9].raw_affiliation_strings | Clinic for Medical Oncology and Hematology, University Hospital Zurich and University of Zurich, 8006 Zurich, Switzerland |
| authorships[10].author.id | https://openalex.org/A5034847353 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-7854-7781 |
| authorships[10].author.display_name | Gerald W. Prager |
| authorships[10].countries | AT |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I4210092129, https://openalex.org/I76134821 |
| authorships[10].affiliations[0].raw_affiliation_string | Department of Medicine I, Clin. Div. of Oncology, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria |
| authorships[10].institutions[0].id | https://openalex.org/I4210092129 |
| authorships[10].institutions[0].ror | https://ror.org/00df3z122 |
| authorships[10].institutions[0].type | healthcare |
| authorships[10].institutions[0].lineage | https://openalex.org/I2802328216, https://openalex.org/I4210092129 |
| authorships[10].institutions[0].country_code | AT |
| authorships[10].institutions[0].display_name | Comprehensive Cancer Center Vienna |
| authorships[10].institutions[1].id | https://openalex.org/I76134821 |
| authorships[10].institutions[1].ror | https://ror.org/05n3x4p02 |
| authorships[10].institutions[1].type | education |
| authorships[10].institutions[1].lineage | https://openalex.org/I76134821 |
| authorships[10].institutions[1].country_code | AT |
| authorships[10].institutions[1].display_name | Medical University of Vienna |
| authorships[10].author_position | last |
| authorships[10].raw_author_name | Gerald W. Prager |
| authorships[10].is_corresponding | True |
| authorships[10].raw_affiliation_strings | Department of Medicine I, Clin. Div. of Oncology, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.mdpi.com/2077-0383/9/6/1772/pdf?version=1592910837 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Different Toxicity Profiles Predict Third Line Treatment Efficacy in Metastatic Colorectal Cancer Patients |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11067 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2730 |
| primary_topic.subfield.display_name | Oncology |
| primary_topic.display_name | Colorectal Cancer Treatments and Studies |
| related_works | https://openalex.org/W1966504330, https://openalex.org/W1979139803, https://openalex.org/W2037631372, https://openalex.org/W4252436151, https://openalex.org/W2030889776, https://openalex.org/W2159000141, https://openalex.org/W4405065477, https://openalex.org/W1978297557, https://openalex.org/W1974041167, https://openalex.org/W2391409986 |
| cited_by_count | 3 |
| counts_by_year[0].year | 2023 |
| counts_by_year[0].cited_by_count | 1 |
| counts_by_year[1].year | 2022 |
| counts_by_year[1].cited_by_count | 1 |
| counts_by_year[2].year | 2020 |
| counts_by_year[2].cited_by_count | 1 |
| locations_count | 5 |
| best_oa_location.id | doi:10.3390/jcm9061772 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2737969411 |
| best_oa_location.source.issn | 2077-0383 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2077-0383 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Journal of Clinical Medicine |
| best_oa_location.source.host_organization | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.mdpi.com/2077-0383/9/6/1772/pdf?version=1592910837 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Journal of Clinical Medicine |
| best_oa_location.landing_page_url | https://doi.org/10.3390/jcm9061772 |
| primary_location.id | doi:10.3390/jcm9061772 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S2737969411 |
| primary_location.source.issn | 2077-0383 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2077-0383 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Journal of Clinical Medicine |
| primary_location.source.host_organization | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.mdpi.com/2077-0383/9/6/1772/pdf?version=1592910837 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Journal of Clinical Medicine |
| primary_location.landing_page_url | https://doi.org/10.3390/jcm9061772 |
| publication_date | 2020-06-07 |
| publication_year | 2020 |
| referenced_works | https://openalex.org/W2889646458, https://openalex.org/W2402327161, https://openalex.org/W2411975622, https://openalex.org/W2327362588, https://openalex.org/W2005348280, https://openalex.org/W1993780950, https://openalex.org/W2167138718, https://openalex.org/W2470575266, https://openalex.org/W2787981425, https://openalex.org/W2147834058, https://openalex.org/W2111851685, https://openalex.org/W2059574293, https://openalex.org/W2587903744, https://openalex.org/W2593374366, https://openalex.org/W2560499218, https://openalex.org/W2045370737, https://openalex.org/W242040007, https://openalex.org/W2508731920, https://openalex.org/W2809071217, https://openalex.org/W2770004975, https://openalex.org/W2954373381, https://openalex.org/W2957360351, https://openalex.org/W2493415491, https://openalex.org/W2591655368 |
| referenced_works_count | 24 |
| abstract_inverted_index.= | 128, 134, 141, 146, 166, 176, 184 |
| abstract_inverted_index.(p | 127, 133, 140, 145, 165, 175, 183 |
| abstract_inverted_index.In | 36, 120, 158, 186 |
| abstract_inverted_index.We | 200 |
| abstract_inverted_index.as | 178, 180, 211 |
| abstract_inverted_index.at | 52 |
| abstract_inverted_index.be | 209 |
| abstract_inverted_index.by | 22 |
| abstract_inverted_index.in | 12, 103, 115, 196, 214 |
| abstract_inverted_index.of | 30, 56, 90, 125, 163, 192 |
| abstract_inverted_index.on | 44 |
| abstract_inverted_index.or | 50, 74 |
| abstract_inverted_index.we | 188 |
| abstract_inverted_index.DCR | 182 |
| abstract_inverted_index.PFS | 174 |
| abstract_inverted_index.The | 0, 67, 150 |
| abstract_inverted_index.and | 4, 59, 72, 83, 100, 106, 112, 130, 143, 194 |
| abstract_inverted_index.any | 91 |
| abstract_inverted_index.are | 20, 34 |
| abstract_inverted_index.but | 27 |
| abstract_inverted_index.not | 155 |
| abstract_inverted_index.the | 5, 53, 60, 123, 161, 181, 190, 197 |
| abstract_inverted_index.was | 136, 154, 168 |
| abstract_inverted_index.Both | 18 |
| abstract_inverted_index.PFS. | 149 |
| abstract_inverted_index.data | 43 |
| abstract_inverted_index.like | 205 |
| abstract_inverted_index.line | 219 |
| abstract_inverted_index.loss | 132 |
| abstract_inverted_index.mCRC | 45 |
| abstract_inverted_index.oral | 171 |
| abstract_inverted_index.rate | 153 |
| abstract_inverted_index.side | 32 |
| abstract_inverted_index.test | 82 |
| abstract_inverted_index.this | 37 |
| abstract_inverted_index.upon | 117 |
| abstract_inverted_index.used | 210 |
| abstract_inverted_index.well | 179 |
| abstract_inverted_index.were | 65, 77 |
| abstract_inverted_index.with | 48 |
| abstract_inverted_index.(22%) | 102 |
| abstract_inverted_index.(34%) | 114 |
| abstract_inverted_index.(36%) | 111 |
| abstract_inverted_index.exact | 81 |
| abstract_inverted_index.grade | 92 |
| abstract_inverted_index.might | 208 |
| abstract_inverted_index.rare. | 35 |
| abstract_inverted_index.rates | 76 |
| abstract_inverted_index.test, | 85 |
| abstract_inverted_index.which | 207 |
| abstract_inverted_index.while | 170 |
| abstract_inverted_index.(26%), | 99 |
| abstract_inverted_index.(34%), | 97 |
| abstract_inverted_index.(42%), | 108 |
| abstract_inverted_index.(52%), | 95 |
| abstract_inverted_index.0.001) | 167 |
| abstract_inverted_index.0.032) | 177 |
| abstract_inverted_index.0.043) | 147 |
| abstract_inverted_index.0.044) | 129, 135, 142 |
| abstract_inverted_index.Common | 87 |
| abstract_inverted_index.anemia | 98 |
| abstract_inverted_index.beyond | 217 |
| abstract_inverted_index.cancer | 15 |
| abstract_inverted_index.events | 26, 71, 89, 204 |
| abstract_inverted_index.marker | 213 |
| abstract_inverted_index.nausea | 164 |
| abstract_inverted_index.second | 218 |
| abstract_inverted_index.study, | 41 |
| abstract_inverted_index.weight | 131 |
| abstract_inverted_index.(mCRC). | 17 |
| abstract_inverted_index.0.039). | 185 |
| abstract_inverted_index.Austria | 58 |
| abstract_inverted_index.Medical | 54 |
| abstract_inverted_index.Vienna, | 57 |
| abstract_inverted_index.Zurich, | 63 |
| abstract_inverted_index.adverse | 25, 70, 88, 203 |
| abstract_inverted_index.between | 69 |
| abstract_inverted_index.control | 152 |
| abstract_inverted_index.disease | 151 |
| abstract_inverted_index.effects | 33 |
| abstract_inverted_index.fatigue | 94, 107 |
| abstract_inverted_index.therapy | 216 |
| abstract_inverted_index.treated | 47 |
| abstract_inverted_index.whereas | 138 |
| abstract_inverted_index.Hospital | 62 |
| abstract_inverted_index.analyses | 29 |
| abstract_inverted_index.clinical | 42 |
| abstract_inverted_index.describe | 201 |
| abstract_inverted_index.detailed | 28 |
| abstract_inverted_index.efficacy | 191 |
| abstract_inverted_index.improved | 10 |
| abstract_inverted_index.included | 93 |
| abstract_inverted_index.log-rank | 84 |
| abstract_inverted_index.patients | 16, 46, 105, 116, 122 |
| abstract_inverted_index.response | 73 |
| abstract_inverted_index.setting. | 199 |
| abstract_inverted_index.survival | 11, 75 |
| abstract_inverted_index.syndrome | 110 |
| abstract_inverted_index.(TAS-102) | 3 |
| abstract_inverted_index.affected. | 157 |
| abstract_inverted_index.different | 23 |
| abstract_inverted_index.inhibitor | 7 |
| abstract_inverted_index.mucositis | 172 |
| abstract_inverted_index.patients, | 160 |
| abstract_inverted_index.predicted | 148, 173 |
| abstract_inverted_index.real-life | 40, 198 |
| abstract_inverted_index.surrogate | 212 |
| abstract_inverted_index.underline | 189 |
| abstract_inverted_index.Fisher’s | 80 |
| abstract_inverted_index.University | 55, 61 |
| abstract_inverted_index.anticancer | 215 |
| abstract_inverted_index.calculated | 78 |
| abstract_inverted_index.collected. | 66 |
| abstract_inverted_index.colorectal | 14 |
| abstract_inverted_index.hoarseness | 113 |
| abstract_inverted_index.leukopenia | 101, 126, 139 |
| abstract_inverted_index.metastatic | 13 |
| abstract_inverted_index.nucleoside | 1 |
| abstract_inverted_index.performing | 79 |
| abstract_inverted_index.predictive | 31, 202 |
| abstract_inverted_index.prevalence | 124, 162 |
| abstract_inverted_index.treatment. | 119, 220 |
| abstract_inverted_index.treatments | 19 |
| abstract_inverted_index.Switzerland | 64 |
| abstract_inverted_index.conclusion, | 187 |
| abstract_inverted_index.correlation | 68 |
| abstract_inverted_index.multikinase | 6 |
| abstract_inverted_index.neutropenia | 144 |
| abstract_inverted_index.prognostic, | 137, 169 |
| abstract_inverted_index.regorafenib | 8, 51, 118, 195 |
| abstract_inverted_index.characterized | 21 |
| abstract_inverted_index.respectively. | 86 |
| abstract_inverted_index.significantly | 9, 156 |
| abstract_inverted_index.hand-foot-skin | 109 |
| abstract_inverted_index.nausea/vertigo | 96 |
| abstract_inverted_index.observational, | 39 |
| abstract_inverted_index.retrospective, | 38 |
| abstract_inverted_index.treatment-related | 24 |
| abstract_inverted_index.regorafenib-treated | 159 |
| abstract_inverted_index.trifluridine/tipiracil | 2, 49, 104, 121, 193 |
| abstract_inverted_index.neutropenia/leukopenia, | 206 |
| cited_by_percentile_year.max | 94 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5063566935, https://openalex.org/A5034847353 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 11 |
| corresponding_institution_ids | https://openalex.org/I202697423, https://openalex.org/I4210092129, https://openalex.org/I4210100468, https://openalex.org/I76134821 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8500000238418579 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.57146328 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |