Differential methylation of linoleic acid pathway genes is associated with PTSD symptoms – a longitudinal study with Burundian soldiers returning from a war zone Article Swipe
Anselm Crombach
,
Anja C. Zeller
,
Vanja Vukojević
,
Corina Nandi
,
Manassé Bambonyé
,
Dominique J.‐F. de Quervain
,
Andreas Papassotiropoulos
,
Thomas Elbert
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1038/s41398-024-02757-7
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1038/s41398-024-02757-7
Soldiers may be exposed to traumatic stress during combat deployment and thus are at risk for developing posttraumatic stress disorder (PTSD). Genetic and epigenetic evidence suggests that PTSD is linked to forming stress-related memories. In the current study, we investigated post-deployment associations of PTSD symptoms with differential DNA methylation in a sample of Burundian soldiers returning from the African Union Mission in Somalia’s war zone. We used a matched longitudinal study design to explore epigenetic changes associated with PTSD symptoms in N = 191 participants. PTSD symptoms and saliva samples were collected at 1–3 (t1) and 9–14 months (t2) after the return of the soldiers to their home base. Individuals with either worsening or improving PTSD symptoms were matched for age, stressful, traumatic and self-perpetrated events prior to the post-assessment, traumatic and violent experiences between the post- and the follow-up assessment, and violence experienced during childhood. A mixed model analysis was conducted to identify top nominally significantly differentially methylated genes, which were then used to perform a gene enrichment analysis. The linoleic acid metabolism pathway was significantly associated with post-deployment PTSD symptoms, after accounting for multiple comparisons. Linoleic acid has been linked to memory and immune related processes in previous research. Our findings suggest that differential methylation of linoleic acid pathway genes is associated with PTSD and thus may merit closer inspection as a possible mediator of resilience.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41398-024-02757-7
- https://www.nature.com/articles/s41398-024-02757-7.pdf
- OA Status
- gold
- Cited By
- 6
- References
- 55
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4390984571
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4390984571Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1038/s41398-024-02757-7Digital Object Identifier
- Title
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Differential methylation of linoleic acid pathway genes is associated with PTSD symptoms – a longitudinal study with Burundian soldiers returning from a war zoneWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-01-18Full publication date if available
- Authors
-
Anselm Crombach, Anja C. Zeller, Vanja Vukojević, Corina Nandi, Manassé Bambonyé, Dominique J.‐F. de Quervain, Andreas Papassotiropoulos, Thomas ElbertList of authors in order
- Landing page
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https://doi.org/10.1038/s41398-024-02757-7Publisher landing page
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https://www.nature.com/articles/s41398-024-02757-7.pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
- OA URL
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https://www.nature.com/articles/s41398-024-02757-7.pdfDirect OA link when available
- Concepts
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Epigenetics, Traumatic stress, DNA methylation, Recall, Longitudinal study, Psychiatry, Methylation, Psychology, Clinical psychology, Medicine, Gene, Genetics, Biology, Pathology, Gene expression, Cognitive psychologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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6Total citation count in OpenAlex
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2025: 2, 2024: 4Per-year citation counts (last 5 years)
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55Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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