Differential modulation of pain and associated anxiety by GABAergic neuronal circuits in the lateral habenula Article Swipe
Teng Chen
,
Wenbo Liu
,
S. J. Zhu
,
Abudula Aji
,
Chen Zhang
,
Chutong Zhang
,
Yu‐Jie Duan
,
Jiaxin Zuo
,
Zhe-Chen Liu
,
Haojun Li
,
Yuquan Wang
,
Wen‐Li Mi
,
Qi‐Liang Mao‐Ying
,
Yanqing Wang
,
Yu‐Xia Chu
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1073/pnas.2409443121
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1073/pnas.2409443121
Persistent pain frequently precipitates the development of anxiety disorders, yet the underlying mechanisms are not fully understood. In this study, we employed a mouse model that simulates trigeminal neuralgia and observed a marked reduction in the activity of GABAergic neurons in the lateral habenula (LHb), a critical region for modulating pain and anxiety. We utilized precise optogenetic and chemogenetic techniques to modulate these neurons, which significantly alleviated behaviors associated with pain and anxiety. Our investigations revealed an inhibitory pathway from the LHb GABAergic neurons to the posterior paraventricular thalamus. Activation of this pathway primarily mitigated pain-related behaviors, with minimal effects on anxiety. Conversely, interactions between GABAergic and glutamatergic neurons within the LHb were essential in alleviating both pain and anxiety following trigeminal nerve damage. Additionally, we identified that β-sitosterol interacts directly with LHb GABAergic neurons via the estrogen receptor α, providing dual therapeutic effects for both pain and anxiety. These findings highlight the critical role of reduced GABAergic neuronal activity in the LHb in the intersection of pain and anxiety, pointing to promising therapeutic possibilities.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1073/pnas.2409443121
- OA Status
- green
- Cited By
- 4
- References
- 46
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4404534133
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4404534133Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1073/pnas.2409443121Digital Object Identifier
- Title
-
Differential modulation of pain and associated anxiety by GABAergic neuronal circuits in the lateral habenulaWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-11-20Full publication date if available
- Authors
-
Teng Chen, Wenbo Liu, S. J. Zhu, Abudula Aji, Chen Zhang, Chutong Zhang, Yu‐Jie Duan, Jiaxin Zuo, Zhe-Chen Liu, Haojun Li, Yuquan Wang, Wen‐Li Mi, Qi‐Liang Mao‐Ying, Yanqing Wang, Yu‐Xia ChuList of authors in order
- Landing page
-
https://doi.org/10.1073/pnas.2409443121Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/11621741Direct OA link when available
- Concepts
-
GABAergic, Neuroscience, Optogenetics, Glutamatergic, Anxiety, Thalamus, Inhibitory postsynaptic potential, Psychology, Nociception, Medicine, Glutamate receptor, Internal medicine, Receptor, PsychiatryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
4Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 4Per-year citation counts (last 5 years)
- References (count)
-
46Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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