Differing roles of pyruvate dehydrogenase kinases during mouse oocyte maturation Article Swipe
Xiaojing Hou
,
Liang Zhang
,
Longsen Han
,
Juan Ge
,
Rujun Ma
,
Xuesen Zhang
,
Kelle H. Moley
,
Tim Schedl
,
Qiang Wang
·
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1242/jcs.167049
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1242/jcs.167049
Pyruvate dehydrogenase kinases (PDKs) modulate energy homeostasis in multiple tissues and cell types, under various nutrient conditions, through phosphorylation of the α subunit (PDHE1α, also known as PDHA1) of the pyruvate dehydrogenase (PDH) complex. However, the roles of PDKs in meiotic maturation are currently unknown. Here, by undertaking knockdown and overexpression analysis of PDK paralogs (PDK1–PDK4) in mouse oocytes, we established the site-specificity of PDKs towards the phosphorylation of three serine residues (Ser232, Ser293 and Ser300) on PDHE1α. We found that PDK3-mediated phosphorylation of Ser293-PDHE1α results in disruption of meiotic spindle morphology and chromosome alignment and decreased total ATP levels, probably through inhibition of PDH activity. Unexpectedly, we discovered that PDK1 and PDK2 promote meiotic maturation, as their knockdown disturbs the assembly of the meiotic apparatus, without significantly altering ATP content. Moreover, phosphorylation of Ser232-PDHE1α was demonstrated to mediate PDK1 and PDK2 action in meiotic maturation, possibly through a mechanism that is distinct from PDH inactivation. These findings reveal that there are divergent roles of PDKs during oocyte maturation and indicate a new mechanism controlling meiotic structure.
Related Topics
Concepts
Biology
Oocyte
Pyruvate kinase
Kinase
Pyruvate dehydrogenase complex
Cell biology
Protein-Serine-Threonine Kinases
Pyruvate dehydrogenase phosphatase
Lactate dehydrogenase
Dehydrogenase
Biochemistry
Metabolism
Enzyme
Glycolysis
Protein kinase A
Embryo
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1242/jcs.167049
- OA Status
- green
- Cited By
- 46
- References
- 50
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2432281306
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2432281306Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1242/jcs.167049Digital Object Identifier
- Title
-
Differing roles of pyruvate dehydrogenase kinases during mouse oocyte maturationWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2015Year of publication
- Publication date
-
2015-05-20Full publication date if available
- Authors
-
Xiaojing Hou, Liang Zhang, Longsen Han, Juan Ge, Rujun Ma, Xuesen Zhang, Kelle H. Moley, Tim Schedl, Qiang WangList of authors in order
- Landing page
-
https://doi.org/10.1242/jcs.167049Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/4510846Direct OA link when available
- Concepts
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Biology, Oocyte, Pyruvate kinase, Kinase, Pyruvate dehydrogenase complex, Cell biology, Protein-Serine-Threonine Kinases, Pyruvate dehydrogenase phosphatase, Lactate dehydrogenase, Dehydrogenase, Biochemistry, Metabolism, Enzyme, Glycolysis, Protein kinase A, EmbryoTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
46Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 12, 2023: 2, 2022: 6, 2021: 5Per-year citation counts (last 5 years)
- References (count)
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50Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.demonstrated | 137 |
| abstract_inverted_index.(PDK1–PDK4) | 56 |
| abstract_inverted_index.PDK3-mediated | 82 |
| abstract_inverted_index.Unexpectedly, | 107 |
| abstract_inverted_index.dehydrogenase | 2, 32 |
| abstract_inverted_index.inactivation. | 156 |
| abstract_inverted_index.significantly | 128 |
| abstract_inverted_index.Ser232-PDHE1α | 135 |
| abstract_inverted_index.Ser293-PDHE1α | 85 |
| abstract_inverted_index.overexpression | 51 |
| abstract_inverted_index.phosphorylation | 19, 68, 83, 133 |
| abstract_inverted_index.site-specificity | 63 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 89 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 9 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/7 |
| sustainable_development_goals[0].score | 0.699999988079071 |
| sustainable_development_goals[0].display_name | Affordable and clean energy |
| citation_normalized_percentile.value | 0.86031703 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |