Differing time-orders of inflammation decrease between ACPA subsets in RA patients suggest differences in underlying inflammatory pathways Article Swipe
X. Matthijssen
,
Ellis Niemantsverdriet
,
Saskia le Cessie
,
Annette H M van der Helm–van Mil
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1093/rheumatology/keaa658
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1093/rheumatology/keaa658
Objectives Advanced imaging modalities have shown that not only joints but also bones and tendon sheaths can be inflamed at diagnosis of RA. We aimed to better understand the time-order in which the inflamed tissues respond to DMARD treatment. Also, because ACPA status may reflect a different pathophysiology, differences in time-order of inflammation decrease were hypothesized between these disease types. Methods A total of 216 consecutive patients presenting with RA (n = 176) or undifferentiated arthritis (n = 40), who all started with conventional synthetic DMARD treatment, were studied. 1.5T contrast-enhanced hand and foot MRIs were performed before treatment and after 4, 12 and 24 months. Cross-lagged models evaluated the influence of two time patterns: a simultaneous pattern (‘change in one inflammatory feature associated with change in another feature’) and a subsequent pattern (‘change in one inflammatory feature preceded change in another feature’). ACPA stratification was performed. Results The median symptom duration at presentation was 13 weeks. Forty-four percent of patients was ACPA-positive. All pairs of inflammatory features decreased simultaneously in all time intervals (0–4/4–12/12–24 months; P < 0.05). Moreover, time-orders were identified: synovitis decrease preceded tenosynovitis decrease (0–4 to >4–12 months; P = 0.02 and 4–12 to >12–24 months; P = 0.03). Largely similar results were obtained in both ACPA subgroups. Additionally, in ACPA-positive but not ACPA-negative patients, synovitis decrease preceded osteitis decrease (4–12 to >12–24 moths; P = 0.002). Conclusion This study increased the understanding of the response to treatment on the tissue level. In addition to simultaneous decrease of inflammation, synovitis decrease preceded tenosynovitis decrease. Differences in time-order of inflammation decrease between ACPA subgroups suggest differences in underlying inflammatory pathways.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/rheumatology/keaa658
- https://academic.oup.com/rheumatology/article-pdf/60/6/2969/38695064/keaa658.pdf
- OA Status
- hybrid
- Cited By
- 9
- References
- 19
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3098891724
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3098891724Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/rheumatology/keaa658Digital Object Identifier
- Title
-
Differing time-orders of inflammation decrease between ACPA subsets in RA patients suggest differences in underlying inflammatory pathwaysWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-09-22Full publication date if available
- Authors
-
X. Matthijssen, Ellis Niemantsverdriet, Saskia le Cessie, Annette H M van der Helm–van MilList of authors in order
- Landing page
-
https://doi.org/10.1093/rheumatology/keaa658Publisher landing page
- PDF URL
-
https://academic.oup.com/rheumatology/article-pdf/60/6/2969/38695064/keaa658.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://academic.oup.com/rheumatology/article-pdf/60/6/2969/38695064/keaa658.pdfDirect OA link when available
- Concepts
-
Medicine, Synovitis, Inflammation, Tenosynovitis, Arthritis, Inflammatory arthritis, Internal medicine, Rheumatoid arthritis, Pathophysiology, Gastroenterology, SurgeryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
9Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 1, 2023: 1, 2022: 6, 2021: 1Per-year citation counts (last 5 years)
- References (count)
-
19Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3098891724 |
|---|---|
| doi | https://doi.org/10.1093/rheumatology/keaa658 |
| ids.doi | https://doi.org/10.1093/rheumatology/keaa658 |
| ids.mag | 3098891724 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/33164106 |
| ids.openalex | https://openalex.org/W3098891724 |
| fwci | 1.85115542 |
| mesh[0].qualifier_ui | Q000627 |
| mesh[0].descriptor_ui | D018501 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | therapeutic use |
| mesh[0].descriptor_name | Antirheumatic Agents |
| mesh[1].qualifier_ui | Q000000981 |
| mesh[1].descriptor_ui | D001172 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | diagnostic imaging |
| mesh[1].descriptor_name | Arthritis, Rheumatoid |
| mesh[2].qualifier_ui | Q000188 |
| mesh[2].descriptor_ui | D001172 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | drug therapy |
| mesh[2].descriptor_name | Arthritis, Rheumatoid |
| mesh[3].qualifier_ui | Q000503 |
| mesh[3].descriptor_ui | D001172 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | physiopathology |
| mesh[3].descriptor_name | Arthritis, Rheumatoid |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D005260 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Female |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D006225 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Hand |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D006801 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Humans |
| mesh[7].qualifier_ui | Q000000981 |
| mesh[7].descriptor_ui | D007249 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | diagnostic imaging |
| mesh[7].descriptor_name | Inflammation |
| mesh[8].qualifier_ui | Q000188 |
| mesh[8].descriptor_ui | D007249 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | drug therapy |
| mesh[8].descriptor_name | Inflammation |
| mesh[9].qualifier_ui | Q000503 |
| mesh[9].descriptor_ui | D007249 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | physiopathology |
| mesh[9].descriptor_name | Inflammation |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D008279 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Magnetic Resonance Imaging |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D008297 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Male |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D008875 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Middle Aged |
| mesh[13].qualifier_ui | Q000000981 |
| mesh[13].descriptor_ui | D010000 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | diagnostic imaging |
| mesh[13].descriptor_name | Osteitis |
| mesh[14].qualifier_ui | Q000188 |
| mesh[14].descriptor_ui | D010000 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | drug therapy |
| mesh[14].descriptor_name | Osteitis |
| mesh[15].qualifier_ui | Q000503 |
| mesh[15].descriptor_ui | D010000 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | physiopathology |
| mesh[15].descriptor_name | Osteitis |
| mesh[16].qualifier_ui | Q000000981 |
| mesh[16].descriptor_ui | D013585 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | diagnostic imaging |
| mesh[16].descriptor_name | Synovitis |
| mesh[17].qualifier_ui | Q000188 |
| mesh[17].descriptor_ui | D013585 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | drug therapy |
| mesh[17].descriptor_name | Synovitis |
| mesh[18].qualifier_ui | Q000503 |
| mesh[18].descriptor_ui | D013585 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | physiopathology |
| mesh[18].descriptor_name | Synovitis |
| mesh[19].qualifier_ui | Q000000981 |
| mesh[19].descriptor_ui | D013717 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | diagnostic imaging |
| mesh[19].descriptor_name | Tenosynovitis |
| mesh[20].qualifier_ui | Q000188 |
| mesh[20].descriptor_ui | D013717 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | drug therapy |
| mesh[20].descriptor_name | Tenosynovitis |
| mesh[21].qualifier_ui | Q000503 |
| mesh[21].descriptor_ui | D013717 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | physiopathology |
| mesh[21].descriptor_name | Tenosynovitis |
| mesh[22].qualifier_ui | |
| mesh[22].descriptor_ui | D013997 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | |
| mesh[22].descriptor_name | Time Factors |
| mesh[23].qualifier_ui | Q000627 |
| mesh[23].descriptor_ui | D018501 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | therapeutic use |
| mesh[23].descriptor_name | Antirheumatic Agents |
| mesh[24].qualifier_ui | Q000000981 |
| mesh[24].descriptor_ui | D001172 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | diagnostic imaging |
| mesh[24].descriptor_name | Arthritis, Rheumatoid |
| mesh[25].qualifier_ui | Q000188 |
| mesh[25].descriptor_ui | D001172 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | drug therapy |
| mesh[25].descriptor_name | Arthritis, Rheumatoid |
| mesh[26].qualifier_ui | Q000503 |
| mesh[26].descriptor_ui | D001172 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | physiopathology |
| mesh[26].descriptor_name | Arthritis, Rheumatoid |
| mesh[27].qualifier_ui | |
| mesh[27].descriptor_ui | D005260 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | |
| mesh[27].descriptor_name | Female |
| mesh[28].qualifier_ui | |
| mesh[28].descriptor_ui | D006225 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | |
| mesh[28].descriptor_name | Hand |
| mesh[29].qualifier_ui | |
| mesh[29].descriptor_ui | D006801 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | |
| mesh[29].descriptor_name | Humans |
| mesh[30].qualifier_ui | Q000000981 |
| mesh[30].descriptor_ui | D007249 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | diagnostic imaging |
| mesh[30].descriptor_name | Inflammation |
| mesh[31].qualifier_ui | Q000188 |
| mesh[31].descriptor_ui | D007249 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | drug therapy |
| mesh[31].descriptor_name | Inflammation |
| mesh[32].qualifier_ui | Q000503 |
| mesh[32].descriptor_ui | D007249 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | physiopathology |
| mesh[32].descriptor_name | Inflammation |
| mesh[33].qualifier_ui | |
| mesh[33].descriptor_ui | D008279 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | |
| mesh[33].descriptor_name | Magnetic Resonance Imaging |
| mesh[34].qualifier_ui | |
| mesh[34].descriptor_ui | D008297 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | |
| mesh[34].descriptor_name | Male |
| mesh[35].qualifier_ui | |
| mesh[35].descriptor_ui | D008875 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | |
| mesh[35].descriptor_name | Middle Aged |
| mesh[36].qualifier_ui | Q000000981 |
| mesh[36].descriptor_ui | D010000 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | diagnostic imaging |
| mesh[36].descriptor_name | Osteitis |
| mesh[37].qualifier_ui | Q000188 |
| mesh[37].descriptor_ui | D010000 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | drug therapy |
| mesh[37].descriptor_name | Osteitis |
| mesh[38].qualifier_ui | Q000503 |
| mesh[38].descriptor_ui | D010000 |
| mesh[38].is_major_topic | False |
| mesh[38].qualifier_name | physiopathology |
| mesh[38].descriptor_name | Osteitis |
| mesh[39].qualifier_ui | Q000000981 |
| mesh[39].descriptor_ui | D013585 |
| mesh[39].is_major_topic | False |
| mesh[39].qualifier_name | diagnostic imaging |
| mesh[39].descriptor_name | Synovitis |
| mesh[40].qualifier_ui | Q000188 |
| mesh[40].descriptor_ui | D013585 |
| mesh[40].is_major_topic | False |
| mesh[40].qualifier_name | drug therapy |
| mesh[40].descriptor_name | Synovitis |
| mesh[41].qualifier_ui | Q000503 |
| mesh[41].descriptor_ui | D013585 |
| mesh[41].is_major_topic | False |
| mesh[41].qualifier_name | physiopathology |
| mesh[41].descriptor_name | Synovitis |
| mesh[42].qualifier_ui | Q000000981 |
| mesh[42].descriptor_ui | D013717 |
| mesh[42].is_major_topic | False |
| mesh[42].qualifier_name | diagnostic imaging |
| mesh[42].descriptor_name | Tenosynovitis |
| mesh[43].qualifier_ui | Q000188 |
| mesh[43].descriptor_ui | D013717 |
| mesh[43].is_major_topic | False |
| mesh[43].qualifier_name | drug therapy |
| mesh[43].descriptor_name | Tenosynovitis |
| mesh[44].qualifier_ui | Q000503 |
| mesh[44].descriptor_ui | D013717 |
| mesh[44].is_major_topic | False |
| mesh[44].qualifier_name | physiopathology |
| mesh[44].descriptor_name | Tenosynovitis |
| mesh[45].qualifier_ui | |
| mesh[45].descriptor_ui | D013997 |
| mesh[45].is_major_topic | False |
| mesh[45].qualifier_name | |
| mesh[45].descriptor_name | Time Factors |
| mesh[46].qualifier_ui | Q000627 |
| mesh[46].descriptor_ui | D018501 |
| mesh[46].is_major_topic | False |
| mesh[46].qualifier_name | therapeutic use |
| mesh[46].descriptor_name | Antirheumatic Agents |
| mesh[47].qualifier_ui | Q000000981 |
| mesh[47].descriptor_ui | D001172 |
| mesh[47].is_major_topic | False |
| mesh[47].qualifier_name | diagnostic imaging |
| mesh[47].descriptor_name | Arthritis, Rheumatoid |
| mesh[48].qualifier_ui | Q000188 |
| mesh[48].descriptor_ui | D001172 |
| mesh[48].is_major_topic | False |
| mesh[48].qualifier_name | drug therapy |
| mesh[48].descriptor_name | Arthritis, Rheumatoid |
| mesh[49].qualifier_ui | Q000503 |
| mesh[49].descriptor_ui | D001172 |
| mesh[49].is_major_topic | False |
| mesh[49].qualifier_name | physiopathology |
| mesh[49].descriptor_name | Arthritis, Rheumatoid |
| type | article |
| title | Differing time-orders of inflammation decrease between ACPA subsets in RA patients suggest differences in underlying inflammatory pathways |
| biblio.issue | 6 |
| biblio.volume | 60 |
| biblio.last_page | 2975 |
| biblio.first_page | 2969 |
| grants[0].funder | https://openalex.org/F4320338335 |
| grants[0].award_id | |
| grants[0].funder_display_name | H2020 European Research Council |
| topics[0].id | https://openalex.org/T10200 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9997000098228455 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2745 |
| topics[0].subfield.display_name | Rheumatology |
| topics[0].display_name | Rheumatoid Arthritis Research and Therapies |
| topics[1].id | https://openalex.org/T11092 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9983999729156494 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2745 |
| topics[1].subfield.display_name | Rheumatology |
| topics[1].display_name | Spondyloarthritis Studies and Treatments |
| topics[2].id | https://openalex.org/T10837 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9980999827384949 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2708 |
| topics[2].subfield.display_name | Dermatology |
| topics[2].display_name | Dermatology and Skin Diseases |
| funders[0].id | https://openalex.org/F4320338335 |
| funders[0].ror | https://ror.org/0472cxd90 |
| funders[0].display_name | H2020 European Research Council |
| is_xpac | False |
| apc_list.value | 3192 |
| apc_list.currency | GBP |
| apc_list.value_usd | 3915 |
| apc_paid.value | 3192 |
| apc_paid.currency | GBP |
| apc_paid.value_usd | 3915 |
| concepts[0].id | https://openalex.org/C71924100 |
| concepts[0].level | 0 |
| concepts[0].score | 0.9429473876953125 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[0].display_name | Medicine |
| concepts[1].id | https://openalex.org/C2779244835 |
| concepts[1].level | 3 |
| concepts[1].score | 0.7827546000480652 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q538432 |
| concepts[1].display_name | Synovitis |
| concepts[2].id | https://openalex.org/C2776914184 |
| concepts[2].level | 2 |
| concepts[2].score | 0.6829892992973328 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q101991 |
| concepts[2].display_name | Inflammation |
| concepts[3].id | https://openalex.org/C2776751720 |
| concepts[3].level | 2 |
| concepts[3].score | 0.6367939114570618 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q1505689 |
| concepts[3].display_name | Tenosynovitis |
| concepts[4].id | https://openalex.org/C2777077863 |
| concepts[4].level | 2 |
| concepts[4].score | 0.5400053262710571 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q170990 |
| concepts[4].display_name | Arthritis |
| concepts[5].id | https://openalex.org/C2776821229 |
| concepts[5].level | 3 |
| concepts[5].score | 0.5386528372764587 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q16965166 |
| concepts[5].display_name | Inflammatory arthritis |
| concepts[6].id | https://openalex.org/C126322002 |
| concepts[6].level | 1 |
| concepts[6].score | 0.4961293637752533 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[6].display_name | Internal medicine |
| concepts[7].id | https://openalex.org/C2777575956 |
| concepts[7].level | 2 |
| concepts[7].score | 0.4888398051261902 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q187255 |
| concepts[7].display_name | Rheumatoid arthritis |
| concepts[8].id | https://openalex.org/C10162356 |
| concepts[8].level | 2 |
| concepts[8].score | 0.4757354259490967 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q1135939 |
| concepts[8].display_name | Pathophysiology |
| concepts[9].id | https://openalex.org/C90924648 |
| concepts[9].level | 1 |
| concepts[9].score | 0.3463553786277771 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q120569 |
| concepts[9].display_name | Gastroenterology |
| concepts[10].id | https://openalex.org/C141071460 |
| concepts[10].level | 1 |
| concepts[10].score | 0.2974468469619751 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q40821 |
| concepts[10].display_name | Surgery |
| keywords[0].id | https://openalex.org/keywords/medicine |
| keywords[0].score | 0.9429473876953125 |
| keywords[0].display_name | Medicine |
| keywords[1].id | https://openalex.org/keywords/synovitis |
| keywords[1].score | 0.7827546000480652 |
| keywords[1].display_name | Synovitis |
| keywords[2].id | https://openalex.org/keywords/inflammation |
| keywords[2].score | 0.6829892992973328 |
| keywords[2].display_name | Inflammation |
| keywords[3].id | https://openalex.org/keywords/tenosynovitis |
| keywords[3].score | 0.6367939114570618 |
| keywords[3].display_name | Tenosynovitis |
| keywords[4].id | https://openalex.org/keywords/arthritis |
| keywords[4].score | 0.5400053262710571 |
| keywords[4].display_name | Arthritis |
| keywords[5].id | https://openalex.org/keywords/inflammatory-arthritis |
| keywords[5].score | 0.5386528372764587 |
| keywords[5].display_name | Inflammatory arthritis |
| keywords[6].id | https://openalex.org/keywords/internal-medicine |
| keywords[6].score | 0.4961293637752533 |
| keywords[6].display_name | Internal medicine |
| keywords[7].id | https://openalex.org/keywords/rheumatoid-arthritis |
| keywords[7].score | 0.4888398051261902 |
| keywords[7].display_name | Rheumatoid arthritis |
| keywords[8].id | https://openalex.org/keywords/pathophysiology |
| keywords[8].score | 0.4757354259490967 |
| keywords[8].display_name | Pathophysiology |
| keywords[9].id | https://openalex.org/keywords/gastroenterology |
| keywords[9].score | 0.3463553786277771 |
| keywords[9].display_name | Gastroenterology |
| keywords[10].id | https://openalex.org/keywords/surgery |
| keywords[10].score | 0.2974468469619751 |
| keywords[10].display_name | Surgery |
| language | en |
| locations[0].id | doi:10.1093/rheumatology/keaa658 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S183989336 |
| locations[0].source.issn | 1462-0324, 1462-0332 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 1462-0324 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Lara D. Veeken |
| locations[0].source.host_organization | https://openalex.org/P4310311648 |
| locations[0].source.host_organization_name | Oxford University Press |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310311648 |
| locations[0].license | cc-by-nc |
| locations[0].pdf_url | https://academic.oup.com/rheumatology/article-pdf/60/6/2969/38695064/keaa658.pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by-nc |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Rheumatology |
| locations[0].landing_page_url | https://doi.org/10.1093/rheumatology/keaa658 |
| locations[1].id | pmid:33164106 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Rheumatology (Oxford, England) |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/33164106 |
| locations[2].id | pmh:eur:oai:pure.eur.nl:publications/7a695d39-f9aa-4b1a-9a1a-1b9f87beedcd |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306401843 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | Data Archiving and Networked Services (DANS) |
| locations[2].source.host_organization | https://openalex.org/I1322597698 |
| locations[2].source.host_organization_name | Royal Netherlands Academy of Arts and Sciences |
| locations[2].source.host_organization_lineage | https://openalex.org/I1322597698 |
| locations[2].license | cc-by-nc |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | info:eu-repo/semantics/article |
| locations[2].license_id | https://openalex.org/licenses/cc-by-nc |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Rheumatology (United Kingdom), 60(6), 2969 - 2975. Oxford University Press |
| locations[2].landing_page_url | https://pure.eur.nl/en/publications/7a695d39-f9aa-4b1a-9a1a-1b9f87beedcd |
| locations[3].id | pmh:oai:scholarlypublications.universiteitleiden.nl:item_3276073 |
| locations[3].is_oa | True |
| locations[3].source | |
| locations[3].license | cc-by-nc |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Article / Letter to editor |
| locations[3].license_id | https://openalex.org/licenses/cc-by-nc |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Rheumatology |
| locations[3].landing_page_url | https://hdl.handle.net/1887/3276073 |
| locations[4].id | pmh:oai:pure.eur.nl:publications/7a695d39-f9aa-4b1a-9a1a-1b9f87beedcd |
| locations[4].is_oa | False |
| locations[4].source.id | https://openalex.org/S4306400063 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | Scopus (Elsevier) |
| locations[4].source.host_organization | |
| locations[4].source.host_organization_name | |
| locations[4].source.host_organization_lineage | |
| locations[4].license | |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | |
| locations[4].license_id | |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | |
| locations[4].landing_page_url | http://www.scopus.com/inward/record.url?scp=85108742355&partnerID=8YFLogxK |
| locations[5].id | pmh:oai:repub.eur.nl:136715 |
| locations[5].is_oa | True |
| locations[5].source.id | https://openalex.org/S4306400997 |
| locations[5].source.issn | |
| locations[5].source.type | repository |
| locations[5].source.is_oa | False |
| locations[5].source.issn_l | |
| locations[5].source.is_core | False |
| locations[5].source.is_in_doaj | False |
| locations[5].source.display_name | RePub (Erasmus University, Rotterdam) |
| locations[5].source.host_organization | https://openalex.org/I913958620 |
| locations[5].source.host_organization_name | Erasmus University Rotterdam |
| locations[5].source.host_organization_lineage | https://openalex.org/I913958620 |
| locations[5].license | other-oa |
| locations[5].pdf_url | |
| locations[5].version | submittedVersion |
| locations[5].raw_type | info:eu-repo/semantics/article |
| locations[5].license_id | https://openalex.org/licenses/other-oa |
| locations[5].is_accepted | False |
| locations[5].is_published | False |
| locations[5].raw_source_name | Rheumatology (United Kingdom) vol. 60 no. 6, pp. 2969-2975 |
| locations[5].landing_page_url | http://repub.eur.nl/pub/136715 |
| locations[6].id | pmh:oai:pubmedcentral.nih.gov:8213431 |
| locations[6].is_oa | True |
| locations[6].source.id | https://openalex.org/S2764455111 |
| locations[6].source.issn | |
| locations[6].source.type | repository |
| locations[6].source.is_oa | False |
| locations[6].source.issn_l | |
| locations[6].source.is_core | False |
| locations[6].source.is_in_doaj | False |
| locations[6].source.display_name | PubMed Central |
| locations[6].source.host_organization | https://openalex.org/I1299303238 |
| locations[6].source.host_organization_name | National Institutes of Health |
| locations[6].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[6].license | other-oa |
| locations[6].pdf_url | |
| locations[6].version | submittedVersion |
| locations[6].raw_type | Text |
| locations[6].license_id | https://openalex.org/licenses/other-oa |
| locations[6].is_accepted | False |
| locations[6].is_published | False |
| locations[6].raw_source_name | Rheumatology (Oxford) |
| locations[6].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/8213431 |
| locations[7].id | pmh:oai:scholarlypublications.universiteitleiden.nl:item_3205157 |
| locations[7].is_oa | True |
| locations[7].source | |
| locations[7].license | cc-by-nc |
| locations[7].pdf_url | |
| locations[7].version | submittedVersion |
| locations[7].raw_type | Article / Letter to editor |
| locations[7].license_id | https://openalex.org/licenses/cc-by-nc |
| locations[7].is_accepted | False |
| locations[7].is_published | False |
| locations[7].raw_source_name | Rheumatology |
| locations[7].landing_page_url | https://hdl.handle.net/1887/3205157 |
| locations[8].id | pmh:eur:oai:repub.eur.nl:136715 |
| locations[8].is_oa | True |
| locations[8].source.id | https://openalex.org/S4306401843 |
| locations[8].source.issn | |
| locations[8].source.type | repository |
| locations[8].source.is_oa | False |
| locations[8].source.issn_l | |
| locations[8].source.is_core | False |
| locations[8].source.is_in_doaj | False |
| locations[8].source.display_name | Data Archiving and Networked Services (DANS) |
| locations[8].source.host_organization | https://openalex.org/I1322597698 |
| locations[8].source.host_organization_name | Royal Netherlands Academy of Arts and Sciences |
| locations[8].source.host_organization_lineage | https://openalex.org/I1322597698 |
| locations[8].license | other-oa |
| locations[8].pdf_url | |
| locations[8].version | submittedVersion |
| locations[8].raw_type | info:eu-repo/semantics/article |
| locations[8].license_id | https://openalex.org/licenses/other-oa |
| locations[8].is_accepted | False |
| locations[8].is_published | False |
| locations[8].raw_source_name | |
| locations[8].landing_page_url | http://hdl.handle.net/1765/136715 |
| locations[9].id | pmh:lumc:oai:scholarlypublications.universiteitleiden.nl:item_3276073 |
| locations[9].is_oa | True |
| locations[9].source.id | https://openalex.org/S4306401843 |
| locations[9].source.issn | |
| locations[9].source.type | repository |
| locations[9].source.is_oa | False |
| locations[9].source.issn_l | |
| locations[9].source.is_core | False |
| locations[9].source.is_in_doaj | False |
| locations[9].source.display_name | Data Archiving and Networked Services (DANS) |
| locations[9].source.host_organization | https://openalex.org/I1322597698 |
| locations[9].source.host_organization_name | Royal Netherlands Academy of Arts and Sciences |
| locations[9].source.host_organization_lineage | https://openalex.org/I1322597698 |
| locations[9].license | cc-by-nc |
| locations[9].pdf_url | |
| locations[9].version | submittedVersion |
| locations[9].raw_type | info:eu-repo/semantics/article |
| locations[9].license_id | https://openalex.org/licenses/cc-by-nc |
| locations[9].is_accepted | False |
| locations[9].is_published | False |
| locations[9].raw_source_name | Rheumatology, 60(6), 2969 - 2975. Oxford University Press ({OUP}) |
| locations[9].landing_page_url | http://hdl.handle.net/1887/3276073 |
| locations[10].id | pmh:lumc:oai:scholarlypublications.universiteitleiden.nl:item_3205157 |
| locations[10].is_oa | True |
| locations[10].source.id | https://openalex.org/S4306401843 |
| locations[10].source.issn | |
| locations[10].source.type | repository |
| locations[10].source.is_oa | False |
| locations[10].source.issn_l | |
| locations[10].source.is_core | False |
| locations[10].source.is_in_doaj | False |
| locations[10].source.display_name | Data Archiving and Networked Services (DANS) |
| locations[10].source.host_organization | https://openalex.org/I1322597698 |
| locations[10].source.host_organization_name | Royal Netherlands Academy of Arts and Sciences |
| locations[10].source.host_organization_lineage | https://openalex.org/I1322597698 |
| locations[10].license | cc-by-nc |
| locations[10].pdf_url | |
| locations[10].version | submittedVersion |
| locations[10].raw_type | info:eu-repo/semantics/article |
| locations[10].license_id | https://openalex.org/licenses/cc-by-nc |
| locations[10].is_accepted | False |
| locations[10].is_published | False |
| locations[10].raw_source_name | Rheumatology, 60(6), 2969 - 2975. OXFORD UNIV PRESS |
| locations[10].landing_page_url | http://hdl.handle.net/1887/3205157 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5002337454 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-7332-8072 |
| authorships[0].author.display_name | X. Matthijssen |
| authorships[0].countries | NL |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I2800006345 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands |
| authorships[0].institutions[0].id | https://openalex.org/I2800006345 |
| authorships[0].institutions[0].ror | https://ror.org/05xvt9f17 |
| authorships[0].institutions[0].type | healthcare |
| authorships[0].institutions[0].lineage | https://openalex.org/I2800006345 |
| authorships[0].institutions[0].country_code | NL |
| authorships[0].institutions[0].display_name | Leiden University Medical Center |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Xanthe M E Matthijssen |
| authorships[0].is_corresponding | True |
| authorships[0].raw_affiliation_strings | Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands |
| authorships[1].author.id | https://openalex.org/A5088709470 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-5781-3817 |
| authorships[1].author.display_name | Ellis Niemantsverdriet |
| authorships[1].countries | NL |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I2800006345 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands |
| authorships[1].institutions[0].id | https://openalex.org/I2800006345 |
| authorships[1].institutions[0].ror | https://ror.org/05xvt9f17 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I2800006345 |
| authorships[1].institutions[0].country_code | NL |
| authorships[1].institutions[0].display_name | Leiden University Medical Center |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Ellis Niemantsverdriet |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands |
| authorships[2].author.id | https://openalex.org/A5078835349 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-2154-4923 |
| authorships[2].author.display_name | Saskia le Cessie |
| authorships[2].countries | NL |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I2800006345 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Biomedical Data Science, Leiden University Medical Center, Leiden, The Netherlands |
| authorships[2].affiliations[1].institution_ids | https://openalex.org/I2800006345 |
| authorships[2].affiliations[1].raw_affiliation_string | Department of Epidemiology, Leiden University Medical Center, Leiden, The Netherlands |
| authorships[2].institutions[0].id | https://openalex.org/I2800006345 |
| authorships[2].institutions[0].ror | https://ror.org/05xvt9f17 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I2800006345 |
| authorships[2].institutions[0].country_code | NL |
| authorships[2].institutions[0].display_name | Leiden University Medical Center |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Saskia Le Cessie |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Biomedical Data Science, Leiden University Medical Center, Leiden, The Netherlands, Department of Epidemiology, Leiden University Medical Center, Leiden, The Netherlands |
| authorships[3].author.id | https://openalex.org/A5038669147 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-8572-1437 |
| authorships[3].author.display_name | Annette H M van der Helm–van Mil |
| authorships[3].countries | NL |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I2801952686 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Rheumatology, Erasmus Medical Center, Rotterdam, The Netherlands |
| authorships[3].affiliations[1].institution_ids | https://openalex.org/I2800006345 |
| authorships[3].affiliations[1].raw_affiliation_string | Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands |
| authorships[3].institutions[0].id | https://openalex.org/I2801952686 |
| authorships[3].institutions[0].ror | https://ror.org/018906e22 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I2801952686 |
| authorships[3].institutions[0].country_code | NL |
| authorships[3].institutions[0].display_name | Erasmus MC |
| authorships[3].institutions[1].id | https://openalex.org/I2800006345 |
| authorships[3].institutions[1].ror | https://ror.org/05xvt9f17 |
| authorships[3].institutions[1].type | healthcare |
| authorships[3].institutions[1].lineage | https://openalex.org/I2800006345 |
| authorships[3].institutions[1].country_code | NL |
| authorships[3].institutions[1].display_name | Leiden University Medical Center |
| authorships[3].author_position | last |
| authorships[3].raw_author_name | Annette H M van der Helm-van Mil |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Rheumatology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://academic.oup.com/rheumatology/article-pdf/60/6/2969/38695064/keaa658.pdf |
| open_access.oa_status | hybrid |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Differing time-orders of inflammation decrease between ACPA subsets in RA patients suggest differences in underlying inflammatory pathways |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10200 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9997000098228455 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2745 |
| primary_topic.subfield.display_name | Rheumatology |
| primary_topic.display_name | Rheumatoid Arthritis Research and Therapies |
| related_works | https://openalex.org/W2559615893, https://openalex.org/W4302152094, https://openalex.org/W4206535905, https://openalex.org/W2553477384, https://openalex.org/W4220806577, https://openalex.org/W3044001830, https://openalex.org/W2791550347, https://openalex.org/W1449540316, https://openalex.org/W2930559785, https://openalex.org/W3165199492 |
| cited_by_count | 9 |
| counts_by_year[0].year | 2024 |
| counts_by_year[0].cited_by_count | 1 |
| counts_by_year[1].year | 2023 |
| counts_by_year[1].cited_by_count | 1 |
| counts_by_year[2].year | 2022 |
| counts_by_year[2].cited_by_count | 6 |
| counts_by_year[3].year | 2021 |
| counts_by_year[3].cited_by_count | 1 |
| locations_count | 11 |
| best_oa_location.id | doi:10.1093/rheumatology/keaa658 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S183989336 |
| best_oa_location.source.issn | 1462-0324, 1462-0332 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 1462-0324 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Lara D. Veeken |
| best_oa_location.source.host_organization | https://openalex.org/P4310311648 |
| best_oa_location.source.host_organization_name | Oxford University Press |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310311648 |
| best_oa_location.license | cc-by-nc |
| best_oa_location.pdf_url | https://academic.oup.com/rheumatology/article-pdf/60/6/2969/38695064/keaa658.pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by-nc |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Rheumatology |
| best_oa_location.landing_page_url | https://doi.org/10.1093/rheumatology/keaa658 |
| primary_location.id | doi:10.1093/rheumatology/keaa658 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S183989336 |
| primary_location.source.issn | 1462-0324, 1462-0332 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 1462-0324 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Lara D. Veeken |
| primary_location.source.host_organization | https://openalex.org/P4310311648 |
| primary_location.source.host_organization_name | Oxford University Press |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310311648 |
| primary_location.license | cc-by-nc |
| primary_location.pdf_url | https://academic.oup.com/rheumatology/article-pdf/60/6/2969/38695064/keaa658.pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by-nc |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Rheumatology |
| primary_location.landing_page_url | https://doi.org/10.1093/rheumatology/keaa658 |
| publication_date | 2020-09-22 |
| publication_year | 2020 |
| referenced_works | https://openalex.org/W2148561254, https://openalex.org/W2901947246, https://openalex.org/W2613290642, https://openalex.org/W1978567076, https://openalex.org/W2810259434, https://openalex.org/W3004031783, https://openalex.org/W2101387806, https://openalex.org/W1827246, https://openalex.org/W1790237971, https://openalex.org/W2142396487, https://openalex.org/W1831078481, https://openalex.org/W2549510815, https://openalex.org/W2109968028, https://openalex.org/W2152721826, https://openalex.org/W2168646330, https://openalex.org/W2485182736, https://openalex.org/W2463733172, https://openalex.org/W2809685501, https://openalex.org/W139589005 |
| referenced_works_count | 19 |
| abstract_inverted_index.= | 72, 78, 194, 202, 230 |
| abstract_inverted_index.A | 62 |
| abstract_inverted_index.P | 177, 193, 201, 229 |
| abstract_inverted_index.a | 46, 116, 131 |
| abstract_inverted_index.(n | 71, 77 |
| abstract_inverted_index.12 | 103 |
| abstract_inverted_index.13 | 156 |
| abstract_inverted_index.24 | 105 |
| abstract_inverted_index.4, | 102 |
| abstract_inverted_index.In | 247 |
| abstract_inverted_index.RA | 70 |
| abstract_inverted_index.We | 24 |
| abstract_inverted_index.at | 20, 153 |
| abstract_inverted_index.be | 18 |
| abstract_inverted_index.in | 31, 50, 120, 127, 135, 141, 171, 209, 214, 260, 270 |
| abstract_inverted_index.of | 22, 52, 64, 112, 160, 166, 238, 252, 262 |
| abstract_inverted_index.on | 243 |
| abstract_inverted_index.or | 74 |
| abstract_inverted_index.to | 26, 37, 190, 198, 226, 241, 249 |
| abstract_inverted_index.216 | 65 |
| abstract_inverted_index.All | 164 |
| abstract_inverted_index.RA. | 23 |
| abstract_inverted_index.The | 149 |
| abstract_inverted_index.all | 81, 172 |
| abstract_inverted_index.and | 14, 93, 100, 104, 130, 196 |
| abstract_inverted_index.but | 11, 216 |
| abstract_inverted_index.can | 17 |
| abstract_inverted_index.may | 44 |
| abstract_inverted_index.not | 8, 217 |
| abstract_inverted_index.one | 121, 136 |
| abstract_inverted_index.the | 29, 33, 110, 236, 239, 244 |
| abstract_inverted_index.two | 113 |
| abstract_inverted_index.was | 146, 155, 162 |
| abstract_inverted_index.who | 80 |
| abstract_inverted_index.0.02 | 195 |
| abstract_inverted_index.1.5T | 90 |
| abstract_inverted_index.176) | 73 |
| abstract_inverted_index.40), | 79 |
| abstract_inverted_index.ACPA | 42, 144, 211, 266 |
| abstract_inverted_index.MRIs | 95 |
| abstract_inverted_index.This | 233 |
| abstract_inverted_index.also | 12 |
| abstract_inverted_index.both | 210 |
| abstract_inverted_index.foot | 94 |
| abstract_inverted_index.hand | 92 |
| abstract_inverted_index.have | 5 |
| abstract_inverted_index.only | 9 |
| abstract_inverted_index.that | 7 |
| abstract_inverted_index.time | 114, 173 |
| abstract_inverted_index.were | 55, 88, 96, 182, 207 |
| abstract_inverted_index.with | 69, 83, 125 |
| abstract_inverted_index.Also, | 40 |
| abstract_inverted_index.DMARD | 38, 86 |
| abstract_inverted_index.after | 101 |
| abstract_inverted_index.aimed | 25 |
| abstract_inverted_index.bones | 13 |
| abstract_inverted_index.pairs | 165 |
| abstract_inverted_index.shown | 6 |
| abstract_inverted_index.study | 234 |
| abstract_inverted_index.these | 58 |
| abstract_inverted_index.total | 63 |
| abstract_inverted_index.which | 32 |
| abstract_inverted_index.(0–4 | 189 |
| abstract_inverted_index.0.03). | 203 |
| abstract_inverted_index.0.05). | 179 |
| abstract_inverted_index.4–12 | 197 |
| abstract_inverted_index.before | 98 |
| abstract_inverted_index.better | 27 |
| abstract_inverted_index.change | 126, 140 |
| abstract_inverted_index.joints | 10 |
| abstract_inverted_index.level. | 246 |
| abstract_inverted_index.median | 150 |
| abstract_inverted_index.models | 108 |
| abstract_inverted_index.moths; | 228 |
| abstract_inverted_index.status | 43 |
| abstract_inverted_index.tendon | 15 |
| abstract_inverted_index.tissue | 245 |
| abstract_inverted_index.types. | 60 |
| abstract_inverted_index.weeks. | 157 |
| abstract_inverted_index.(4–12 | 225 |
| abstract_inverted_index.0.002). | 231 |
| abstract_inverted_index.Largely | 204 |
| abstract_inverted_index.Methods | 61 |
| abstract_inverted_index.Results | 148 |
| abstract_inverted_index.another | 128, 142 |
| abstract_inverted_index.because | 41 |
| abstract_inverted_index.between | 57, 265 |
| abstract_inverted_index.disease | 59 |
| abstract_inverted_index.feature | 123, 138 |
| abstract_inverted_index.imaging | 3 |
| abstract_inverted_index.months. | 106 |
| abstract_inverted_index.months; | 176, 192, 200 |
| abstract_inverted_index.pattern | 118, 133 |
| abstract_inverted_index.percent | 159 |
| abstract_inverted_index.reflect | 45 |
| abstract_inverted_index.respond | 36 |
| abstract_inverted_index.results | 206 |
| abstract_inverted_index.sheaths | 16 |
| abstract_inverted_index.similar | 205 |
| abstract_inverted_index.started | 82 |
| abstract_inverted_index.suggest | 268 |
| abstract_inverted_index.symptom | 151 |
| abstract_inverted_index.tissues | 35 |
| abstract_inverted_index.&lt; | 178 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Advanced | 2 |
| abstract_inverted_index.addition | 248 |
| abstract_inverted_index.decrease | 54, 185, 188, 221, 224, 251, 255, 264 |
| abstract_inverted_index.duration | 152 |
| abstract_inverted_index.features | 168 |
| abstract_inverted_index.inflamed | 19, 34 |
| abstract_inverted_index.obtained | 208 |
| abstract_inverted_index.osteitis | 223 |
| abstract_inverted_index.patients | 67, 161 |
| abstract_inverted_index.preceded | 139, 186, 222, 256 |
| abstract_inverted_index.response | 240 |
| abstract_inverted_index.studied. | 89 |
| abstract_inverted_index.Moreover, | 180 |
| abstract_inverted_index.arthritis | 76 |
| abstract_inverted_index.decrease. | 258 |
| abstract_inverted_index.decreased | 169 |
| abstract_inverted_index.diagnosis | 21 |
| abstract_inverted_index.different | 47 |
| abstract_inverted_index.evaluated | 109 |
| abstract_inverted_index.increased | 235 |
| abstract_inverted_index.influence | 111 |
| abstract_inverted_index.intervals | 174 |
| abstract_inverted_index.pathways. | 273 |
| abstract_inverted_index.patients, | 219 |
| abstract_inverted_index.patterns: | 115 |
| abstract_inverted_index.performed | 97 |
| abstract_inverted_index.subgroups | 267 |
| abstract_inverted_index.synovitis | 184, 220, 254 |
| abstract_inverted_index.synthetic | 85 |
| abstract_inverted_index.treatment | 99, 242 |
| abstract_inverted_index.(‘change | 119, 134 |
| abstract_inverted_index.Conclusion | 232 |
| abstract_inverted_index.Forty-four | 158 |
| abstract_inverted_index.Objectives | 1 |
| abstract_inverted_index.associated | 124 |
| abstract_inverted_index.modalities | 4 |
| abstract_inverted_index.performed. | 147 |
| abstract_inverted_index.presenting | 68 |
| abstract_inverted_index.subgroups. | 212 |
| abstract_inverted_index.subsequent | 132 |
| abstract_inverted_index.time-order | 30, 51, 261 |
| abstract_inverted_index.treatment, | 87 |
| abstract_inverted_index.treatment. | 39 |
| abstract_inverted_index.underlying | 271 |
| abstract_inverted_index.understand | 28 |
| abstract_inverted_index.Differences | 259 |
| abstract_inverted_index.consecutive | 66 |
| abstract_inverted_index.differences | 49, 269 |
| abstract_inverted_index.feature’) | 129 |
| abstract_inverted_index.identified: | 183 |
| abstract_inverted_index.time-orders | 181 |
| abstract_inverted_index.Cross-lagged | 107 |
| abstract_inverted_index.conventional | 84 |
| abstract_inverted_index.feature’). | 143 |
| abstract_inverted_index.hypothesized | 56 |
| abstract_inverted_index.inflammation | 53, 263 |
| abstract_inverted_index.inflammatory | 122, 137, 167, 272 |
| abstract_inverted_index.presentation | 154 |
| abstract_inverted_index.simultaneous | 117, 250 |
| abstract_inverted_index.ACPA-negative | 218 |
| abstract_inverted_index.ACPA-positive | 215 |
| abstract_inverted_index.Additionally, | 213 |
| abstract_inverted_index.inflammation, | 253 |
| abstract_inverted_index.tenosynovitis | 187, 257 |
| abstract_inverted_index.understanding | 237 |
| abstract_inverted_index.&gt;4–12 | 191 |
| abstract_inverted_index.ACPA-positive. | 163 |
| abstract_inverted_index.simultaneously | 170 |
| abstract_inverted_index.stratification | 145 |
| abstract_inverted_index.&gt;12–24 | 199, 227 |
| abstract_inverted_index.pathophysiology, | 48 |
| abstract_inverted_index.undifferentiated | 75 |
| abstract_inverted_index.contrast-enhanced | 91 |
| abstract_inverted_index.(0–4/4–12/12–24 | 175 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5002337454 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 4 |
| corresponding_institution_ids | https://openalex.org/I2800006345 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7599999904632568 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.82871902 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |