Diffuse gastric cancer: histologic, molecular, and genetic basis of disease Article Swipe
Pritish Iyer
,
Maitham A. Moslim
,
Jeffrey M. Farma
,
Crystal S. Denlinger
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.21037/tgh.2020.01.02
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.21037/tgh.2020.01.02
Diffuse gastric cancer (DGC) is a distinct histopathologic and molecular disease, characterized by mutations in CDH1, RHOA, and others. In addition, DGC is associated with familial syndromes, including hereditary DGC and germline mutation in CDH1. Clinically, this subtype of gastric adenocarcinoma is associated with a poor prognosis and possible resistance to available systemic therapies. An understanding of the genetic and molecular underpinnings of DGC may help inform of its clinical behavior and aid in screening, diagnosis, and response to treatment. In this review, we will review the current histologic, molecular, and genetic landscape of DGC and its relevance to clinical practice.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.21037/tgh.2020.01.02
- https://tgh.amegroups.com/article/viewFile/5746/pdf
- OA Status
- diamond
- Cited By
- 36
- References
- 124
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3014015741
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3014015741Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21037/tgh.2020.01.02Digital Object Identifier
- Title
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Diffuse gastric cancer: histologic, molecular, and genetic basis of diseaseWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-03-10Full publication date if available
- Authors
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Pritish Iyer, Maitham A. Moslim, Jeffrey M. Farma, Crystal S. DenlingerList of authors in order
- Landing page
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https://doi.org/10.21037/tgh.2020.01.02Publisher landing page
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https://tgh.amegroups.com/article/viewFile/5746/pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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diamondOpen access status per OpenAlex
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https://tgh.amegroups.com/article/viewFile/5746/pdfDirect OA link when available
- Concepts
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Medicine, CDH1, Disease, Cancer, Germline mutation, Germline, Pathology, Mutation, Bioinformatics, Internal medicine, Oncology, Genetics, Gene, Cadherin, Biology, CellTop concepts (fields/topics) attached by OpenAlex
- Cited by
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36Total citation count in OpenAlex
- Citations by year (recent)
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2025: 9, 2024: 10, 2023: 4, 2022: 4, 2021: 8Per-year citation counts (last 5 years)
- References (count)
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124Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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