Diffusely Abnormal White Matter, T2 Burden of Disease, and Brain Volume in Relapsing‐Remitting Multiple Sclerosis Article Swipe
Alexandra T. Vertinsky
,
David K.B. Li
,
Irene M. Vavasour
,
Vladislav Miropolsky
,
Guojun Zhao
,
Yinshan Zhao
,
Andrew Riddehough
,
George R. Moore
,
Anthony Traboulsee
,
Cornelia Laule
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1111/jon.12574
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1111/jon.12574
BACKGROUND AND PURPOSE Multiple sclerosis (MS) diffusely abnormal white matter (DAWM) is a mildly hyperintense magnetic resonance imaging abnormality distinct from typical lesions. Our goal was to investigate the prevalence and natural history of DAWM in a large cohort ( n = 348) of relapsing–remitting MS (RRMS) patients. METHODS The presence of DAWM and relationship to changes in T 2 burden of disease (BOD), brain volume (brain fractional ratio, BFR), and disability (Expanded Disability Status Scale, EDSS) were investigated at baseline and year 7–8 (long‐term follow‐up, LTF). RESULTS DAWM was present in 25.3% (88 of 348) of patients at baseline. At LTF, DAWM was unchanged in 69.3% (61 of 88), decreased in 28.4% (25 of 88), and increased in 2.3% (2 of 88) of patients. Baseline BOD and change in BOD did not significantly differ between patients with and without DAWM. DAWM was associated with greater reduction in BFR at LTF ( P = .038). DAWM and DAWM change did not predict EDSS or EDSS progression. CONCLUSIONS DAWM is present in a quarter of RRMS patients, and rarely increases or develops de novo. DAWM predicts brain atrophy but does not predict physical disability. Because of its posterior periventricular location, further investigation is warranted to evaluate its relationship to other measures of disability, including visual spatial processing and cognitive function.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/jon.12574
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jon.12574
- OA Status
- bronze
- Cited By
- 15
- References
- 35
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2899085427
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2899085427Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1111/jon.12574Digital Object Identifier
- Title
-
Diffusely Abnormal White Matter, T2 Burden of Disease, and Brain Volume in Relapsing‐Remitting Multiple SclerosisWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-10-30Full publication date if available
- Authors
-
Alexandra T. Vertinsky, David K.B. Li, Irene M. Vavasour, Vladislav Miropolsky, Guojun Zhao, Yinshan Zhao, Andrew Riddehough, George R. Moore, Anthony Traboulsee, Cornelia LauleList of authors in order
- Landing page
-
https://doi.org/10.1111/jon.12574Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jon.12574Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jon.12574Direct OA link when available
- Concepts
-
Medicine, Multiple sclerosis, Expanded Disability Status Scale, White matter, Atrophy, Relapsing remitting, Brain size, Magnetic resonance imaging, Abnormality, Cohort, Internal medicine, Radiology, PsychiatryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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15Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 2, 2022: 1, 2021: 8, 2020: 3Per-year citation counts (last 5 years)
- References (count)
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35Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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