Dimerization of melanocortin 4 receptor controls puberty onset and body size polymorphism Article Swipe
Ruiqi Liu
,
Mike Friedrich
,
Katherina Hemmen
,
Kerstin Jansen
,
Mateus Contar Adolfi
,
Manfred Schartl
,
Katrin G. Heinze
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fendo.2023.1267590
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fendo.2023.1267590
Xiphophorus fish exhibit a clear phenotypic polymorphism in puberty onset and reproductive strategies of males. In X. nigrensis and X. multilineatus , puberty onset is genetically determined and linked to a melanocortin 4 receptor (Mc4r) polymorphism of wild-type and mutant alleles on the sex chromosomes. We hypothesized that Mc4r mutant alleles act on wild-type alleles by a dominant negative effect through receptor dimerization, leading to differential intracellular signaling and effector gene activation. Depending on signaling strength, the onset of puberty either occurs early or is delayed. Here, we show by Förster Resonance Energy Transfer (FRET) that wild-type Xiphophorus Mc4r monomers can form homodimers, but also heterodimers with mutant receptors resulting in compromised signaling which explains the reduced Mc4r signaling in large males. Thus, hetero- vs. homo- dimerization seems to be the key molecular mechanism for the polymorphism in puberty onset and body size in male fish.
Related Topics
Concepts
Biology
Melanocortin
Allele
Melanocortin 4 receptor
Melanocortin 1 receptor
Xiphophorus
Mutant
Receptor
Melanocortin receptor
Wild type
Endocrinology
Genetics
Internal medicine
Gene
Fish <Actinopterygii>
Medicine
Fishery
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fendo.2023.1267590
- OA Status
- gold
- Cited By
- 6
- References
- 44
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4388632214
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4388632214Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fendo.2023.1267590Digital Object Identifier
- Title
-
Dimerization of melanocortin 4 receptor controls puberty onset and body size polymorphismWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
-
2023-11-10Full publication date if available
- Authors
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Ruiqi Liu, Mike Friedrich, Katherina Hemmen, Kerstin Jansen, Mateus Contar Adolfi, Manfred Schartl, Katrin G. HeinzeList of authors in order
- Landing page
-
https://doi.org/10.3389/fendo.2023.1267590Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.3389/fendo.2023.1267590Direct OA link when available
- Concepts
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Biology, Melanocortin, Allele, Melanocortin 4 receptor, Melanocortin 1 receptor, Xiphophorus, Mutant, Receptor, Melanocortin receptor, Wild type, Endocrinology, Genetics, Internal medicine, Gene, Fish
, Medicine, Fishery Top concepts (fields/topics) attached by OpenAlex - Cited by
-
6Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2024: 4Per-year citation counts (last 5 years)
- References (count)
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44Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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