Dimethyl Fumarate Triggers the Antioxidant Defense System in Human Retinal Endothelial Cells through Nrf2 Activation Article Swipe
Federico Manai
,
Marialaura Amadio
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/antiox11101924
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/antiox11101924
Dimethyl fumarate (DMF) is a well-known activator of Nrf2 (NF-E2-related factor 2), used in the treatment of psoriasis and multiple sclerosis. The mechanism of action consists in the modification of the cysteine residues on the Nrf2-inhibitor Keap1, thus leading to the dissociation of these two proteins and the consequent activation of Nrf2. Considering the paucity of evidence of DMF effects in the context of retinal endothelium, this in vitro study investigated the role of DMF in human retinal endothelial cells (HREC). Here, we show for the first time in HREC that DMF activates the Nrf2 pathway, thus leading to an increase in HO-1 protein levels and a decrease in intracellular ROS levels. Furthermore, this molecule also shows beneficial properties in a model of hyperglucose stress, exerting cytoprotective prosurvival effects. The overall collected results suggest that DMF-mediated activation of the Nrf2 pathway may also be a promising strategy in ocular diseases characterized by oxidative stress. This study opens a new perspective on DMF and suggests its potential repositioning in a broader therapeutical context.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/antiox11101924
- https://www.mdpi.com/2076-3921/11/10/1924/pdf?version=1665280884
- OA Status
- gold
- Cited By
- 20
- References
- 64
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4297464615
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Raw OpenAlex JSON
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https://openalex.org/W4297464615Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/antiox11101924Digital Object Identifier
- Title
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Dimethyl Fumarate Triggers the Antioxidant Defense System in Human Retinal Endothelial Cells through Nrf2 ActivationWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-09-28Full publication date if available
- Authors
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Federico Manai, Marialaura AmadioList of authors in order
- Landing page
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https://doi.org/10.3390/antiox11101924Publisher landing page
- PDF URL
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https://www.mdpi.com/2076-3921/11/10/1924/pdf?version=1665280884Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2076-3921/11/10/1924/pdf?version=1665280884Direct OA link when available
- Concepts
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Dimethyl fumarate, Oxidative stress, Retinal, Chemistry, KEAP1, Context (archaeology), Psoriasis, Cell biology, Activator (genetics), Antioxidant, Intracellular, In vitro, Biochemistry, Pharmacology, Immunology, Biology, Multiple sclerosis, Transcription factor, Receptor, Paleontology, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
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20Total citation count in OpenAlex
- Citations by year (recent)
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2025: 11, 2024: 2, 2023: 5, 2022: 2Per-year citation counts (last 5 years)
- References (count)
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64Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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