Diospyrin: biosynthesis, distribution in the plant kingdom, and therapeutic potential Article Swipe
Lutfun Nahar
,
Satyajit D. Sarker
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1007/s11101-025-10200-y
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1007/s11101-025-10200-y
Diospyrin, a naturally occurring bisnaphthoquinone, is chemically known as 5-hydroxy-6-(5-hydroxy-7-methyl-1,4-dioxonaphthalen-2-yl)-7-methylnaphthalene-1,4-dione. It was first isolated from the heartwood of Diospyros montana Roxb. (Ebenaceae) and later was found in several species of the genera Diospyros and Euclea . This bisnaphthoquinone is biosynthesized through the dimerization of 7-methyljuglone, a 1,4-naphthoquinone, via C-2 and C-6’ coupling. Previous in vitro , in vivo and in silico studies have established diospyrin as a bioactive compound with therapeutic potentials; the most prominent therapeutically relevant bioactivities include its antibacterial (especially against Mycobacterium and Staphylococcus species), anticancer/antitumour (mainly against Ehrlich ascites carcinoma, blood, breast, cervical, colon, lung, prostate and skin cancer cell lines), and antiparasitic (particularly against Leishmania , Plasmodium and Trypanosoma parasites) properties. In addition to three major activities, diospyrin was found to possess antiallergic, antidiabetic, antifungal, anti-inflammatory, antinociceptive, antioxidant, antiviral, neuroprotective, and sedative properties. Some information on the plausible mechanisms of action of diospyrin for its major bioactivities is also available in the literature. Diospyrin was shown to produce a certain level of cytotoxicity in normal cells, hepatotoxicity and mutagenicity. Overall, diospyrin could be considered a structural lead for developing new therapeutics for cancers and bacterial and parasitic infections, albeit further preclinical and clinical studies with diospyrin and its structural analogues are still needed. This review presents a comprehensive and updated overview, and a critical appraisal of published information until February 2025 on diospyrin ( 1 ), including its occurrence in the plant kingdom, biosynthesis, therapeutic potential, mechanisms of action and toxicity.
Related Topics
Concepts
Antiparasitic
Cytotoxicity
Biology
Pharmacology
Computational biology
Mechanism of action
Distribution (mathematics)
Antiparasitic agent
Cancer
Chemistry
Prostate cancer
Mode of action
Cancer cell
Tumor cells
Cancer treatment
Cell permeability
Cell
Plant species
Action (physics)
Clinical treatment
Bacteria
Biological activity
Structure–activity relationship
Cancer therapy
Antimicrobial
Medicine
Ehrlich ascites
Cancer research
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1007/s11101-025-10200-y
- OA Status
- hybrid
- References
- 120
- OpenAlex ID
- https://openalex.org/W7106157335
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W7106157335Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1007/s11101-025-10200-yDigital Object Identifier
- Title
-
Diospyrin: biosynthesis, distribution in the plant kingdom, and therapeutic potentialWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-11-20Full publication date if available
- Authors
-
Lutfun Nahar, Satyajit D. SarkerList of authors in order
- Landing page
-
https://doi.org/10.1007/s11101-025-10200-yPublisher landing page
- Open access
-
YesWhether a free full text is available
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hybridOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1007/s11101-025-10200-yDirect OA link when available
- Concepts
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Antiparasitic, Cytotoxicity, Biology, Pharmacology, Computational biology, Mechanism of action, Distribution (mathematics), Antiparasitic agent, Cancer, Chemistry, Prostate cancer, Mode of action, Cancer cell, Tumor cells, Cancer treatment, Cell permeability, Cell, Plant species, Action (physics), Clinical treatment, Bacteria, Biological activity, Structure–activity relationship, Cancer therapy, Antimicrobial, Medicine, Ehrlich ascites, Cancer researchTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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120Number of works referenced by this work
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