Dipeptidyl peptidase-4 inhibitors and gallbladder or biliary disease in type 2 diabetes: systematic review and pairwise and network meta-analysis of randomised controlled trials Article Swipe
Liyun He
,
Jialu Wang
,
Fan Ping
,
Na Yang
,
Jingyue Huang
,
Wei Li
,
Lingling Xu
,
Huabing Zhang
,
Yuxiu Li
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1136/bmj-2021-068882
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1136/bmj-2021-068882
Objective To examine the association between dipeptidyl peptidase-4 inhibitors and gallbladder or biliary diseases. Design Systematic review and pairwise and network meta-analysis. Data sources PubMed, EMBASE, Web of Science, and CENTRAL from inception until 31 July 2021. Eligibility criteria Randomised controlled trials of adult patients with type 2 diabetes who received dipeptidyl peptidase-4 inhibitors, glucagon-like peptide-1 receptor agonists, and sodium-glucose cotransporter-2 inhibitors compared with placebo or other antidiabetes drugs. Main outcome measures Composite of gallbladder or biliary diseases, cholecystitis, cholelithiasis, and biliary diseases. Data extraction and data synthesis Two reviewers independently extracted the data and assessed the quality of the studies. The quality of the evidence for each outcome was assessed using the Grading of Recommendations, Assessment, Development and Evaluations framework (GRADE) approach. The meta-analysis used pooled odds ratios and 95% confidence intervals. Results A total of 82 randomised controlled trials with 104 833 participants were included in the pairwise meta-analysis. Compared with placebo or non-incretin drugs, dipeptidyl peptidase-4 inhibitors were significantly associated with an increased risk of the composite of gallbladder or biliary diseases (odds ratio 1.22 (95%confidence interval 1.04 to 1.43); risk difference 11 (2 to 21) more events per 10 000 person years) and cholecystitis (odds ratio 1.43 (1.14 to 1.79); risk difference 15 (5 to 27) more events per 10 000 person years) but not with the risk of cholelithiasis and biliary diseases. The associations tended to be observed in patients with a longer duration of dipeptidyl peptidase-4 inhibitor treatment. In the network meta-analysis of 184 trials, dipeptidyl peptidase-4 inhibitors increased the risk of the composite of gallbladder or biliary diseases and cholecystitis compared with sodium-glucose cotransporter-2 inhibitors but not compared with glucagon-like peptide-1 receptor agonists. Conclusions Dipeptidyl peptidase-4 inhibitors increased the risk of cholecystitis in randomised controlled trials, especially with a longer treatment duration, which requires more attention from physicians in clinical practice. Systematic review registration PROSPERO CRD42021271647.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1136/bmj-2021-068882
- OA Status
- hybrid
- Cited By
- 33
- References
- 129
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4283711712
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4283711712Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1136/bmj-2021-068882Digital Object Identifier
- Title
-
Dipeptidyl peptidase-4 inhibitors and gallbladder or biliary disease in type 2 diabetes: systematic review and pairwise and network meta-analysis of randomised controlled trialsWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-06-28Full publication date if available
- Authors
-
Liyun He, Jialu Wang, Fan Ping, Na Yang, Jingyue Huang, Wei Li, Lingling Xu, Huabing Zhang, Yuxiu LiList of authors in order
- Landing page
-
https://doi.org/10.1136/bmj-2021-068882Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1136/bmj-2021-068882Direct OA link when available
- Concepts
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Medicine, Odds ratio, Internal medicine, Incretin, Meta-analysis, Confidence interval, Placebo, Gallbladder disease, Randomized controlled trial, Cholecystitis, Gastroenterology, Diabetes mellitus, Type 2 diabetes, Gallbladder, Endocrinology, Pathology, Alternative medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
33Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 10, 2024: 10, 2023: 7, 2022: 6Per-year citation counts (last 5 years)
- References (count)
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129Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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