DIPG-02. LIN28B EXPRESSION IN DIFFUSE MIDLINE GLIOMA Article Swipe
Truman Knowles
,
Shejuan An
,
Tina Huang
,
Jin Qi
,
Amanda Saratsis
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1093/neuonc/noae064.056
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1093/neuonc/noae064.056
BACKGROUND Diffuse midline glioma (DMG) is the most lethal of all childhood cancers. LIN28B is a RNA binding protein expressed in a variety of cancers, which suppresses the let-7 family of microRNAs, which in turn suppresses a plethora of oncogenes. However, the role of LIN28B in DMG has not yet been explored. Therefore, we sought to determine the pattern of expression and potential function of LIN28B in DMG using rare DMG cell lines. METHODS All studies were performed on DMG cell lines (n=6) and controls (normal human astrocytes n=1, human neural stem cells n=1). RNA-Seq was performed using single-read sequencing at 50bp on the Illumina NextSeq 500 Sequencing System. Cells were then treated with DMSO or the LIN28B inhibitor, LI71, and submitted to functional in vitro studies, as well as RNA-Seq and Western Blot analysis. Functional pathways analysis was subsequently performed on resulting gene expression values with Ingenuity Pathways Analysis (Qiagen). RESULTS Differential LIN28B expression was demonstrated across cell lines, with DMG cells expressing greater LIN28B gene and protein levels compared to controls. LIN28B inhibition with small molecule inhibitor LI71 resulted in decreased cell proliferation and migration, in vitro. A total of 946 differentially expressed genes were identified between treatment groups (FC>2 or <-2, p<0.05). Functional pathways analysis of differentially expressed genes implicated Cancer and Neurological Disease as the top disease processes, with Cellular Movement as the top molecular process in cell lines expressing LIN28B. Further, inactivation of Myc signaling was implicated in cells treated with LI71. CONCLUSIONS Our data demonstrates increased LIN28B expression in DMG cell lines compared with controls, with oncogenic effects on cell proliferation and migration. Further investigation of the LIN28B-let7 signaling axis is warranted in order to further explore LIN28B as a novel therapeutic target in DMG.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/neuonc/noae064.056
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- OA Status
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- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4399787794Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1093/neuonc/noae064.056Digital Object Identifier
- Title
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DIPG-02. LIN28B EXPRESSION IN DIFFUSE MIDLINE GLIOMAWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
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2024-06-18Full publication date if available
- Authors
-
Truman Knowles, Shejuan An, Tina Huang, Jin Qi, Amanda SaratsisList of authors in order
- Landing page
-
https://doi.org/10.1093/neuonc/noae064.056Publisher landing page
- PDF URL
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https://academic.oup.com/neuro-oncology/article-pdf/26/Supplement_4/0/58252068/noae064.056.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://academic.oup.com/neuro-oncology/article-pdf/26/Supplement_4/0/58252068/noae064.056.pdfDirect OA link when available
- Concepts
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Glioma, Expression (computer science), Computational biology, Computer science, Biology, Cancer research, Programming languageTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.were | 77, 111, 197 |
| abstract_inverted_index.with | 114, 147, 161, 176, 223, 246, 260, 262 |
| abstract_inverted_index.(DMG) | 5 |
| abstract_inverted_index.(n=6) | 83 |
| abstract_inverted_index.Cells | 110 |
| abstract_inverted_index.LI71, | 120 |
| abstract_inverted_index.LI71. | 247 |
| abstract_inverted_index.cells | 93, 163, 244 |
| abstract_inverted_index.genes | 196, 212 |
| abstract_inverted_index.human | 87, 90 |
| abstract_inverted_index.let-7 | 29 |
| abstract_inverted_index.lines | 82, 233, 258 |
| abstract_inverted_index.n=1). | 94 |
| abstract_inverted_index.novel | 287 |
| abstract_inverted_index.order | 280 |
| abstract_inverted_index.small | 177 |
| abstract_inverted_index.total | 191 |
| abstract_inverted_index.using | 69, 98 |
| abstract_inverted_index.vitro | 126 |
| abstract_inverted_index.which | 26, 33 |
| abstract_inverted_index.Cancer | 214 |
| abstract_inverted_index.LIN28B | 14, 45, 66, 118, 154, 166, 174, 253, 284 |
| abstract_inverted_index.across | 158 |
| abstract_inverted_index.family | 30 |
| abstract_inverted_index.glioma | 4 |
| abstract_inverted_index.groups | 201 |
| abstract_inverted_index.lethal | 9 |
| abstract_inverted_index.levels | 170 |
| abstract_inverted_index.lines, | 160 |
| abstract_inverted_index.lines. | 73 |
| abstract_inverted_index.neural | 91 |
| abstract_inverted_index.sought | 55 |
| abstract_inverted_index.target | 289 |
| abstract_inverted_index.values | 146 |
| abstract_inverted_index.vitro. | 189 |
| abstract_inverted_index.(normal | 86 |
| abstract_inverted_index.Diffuse | 2 |
| abstract_inverted_index.Disease | 217 |
| abstract_inverted_index.Further | 270 |
| abstract_inverted_index.LIN28B. | 235 |
| abstract_inverted_index.METHODS | 74 |
| abstract_inverted_index.NextSeq | 106 |
| abstract_inverted_index.RESULTS | 152 |
| abstract_inverted_index.RNA-Seq | 95, 131 |
| abstract_inverted_index.System. | 109 |
| abstract_inverted_index.Western | 133 |
| abstract_inverted_index.between | 199 |
| abstract_inverted_index.binding | 18 |
| abstract_inverted_index.disease | 221 |
| abstract_inverted_index.effects | 264 |
| abstract_inverted_index.explore | 283 |
| abstract_inverted_index.further | 282 |
| abstract_inverted_index.greater | 165 |
| abstract_inverted_index.midline | 3 |
| abstract_inverted_index.pattern | 59 |
| abstract_inverted_index.process | 230 |
| abstract_inverted_index.protein | 19, 169 |
| abstract_inverted_index.studies | 76 |
| abstract_inverted_index.treated | 113, 245 |
| abstract_inverted_index.variety | 23 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Analysis | 150 |
| abstract_inverted_index.Cellular | 224 |
| abstract_inverted_index.Further, | 236 |
| abstract_inverted_index.However, | 41 |
| abstract_inverted_index.Illumina | 105 |
| abstract_inverted_index.Movement | 225 |
| abstract_inverted_index.Pathways | 149 |
| abstract_inverted_index.analysis | 138, 208 |
| abstract_inverted_index.cancers, | 25 |
| abstract_inverted_index.cancers. | 13 |
| abstract_inverted_index.compared | 171, 259 |
| abstract_inverted_index.controls | 85 |
| abstract_inverted_index.function | 64 |
| abstract_inverted_index.molecule | 178 |
| abstract_inverted_index.pathways | 137, 207 |
| abstract_inverted_index.plethora | 38 |
| abstract_inverted_index.resulted | 181 |
| abstract_inverted_index.studies, | 127 |
| abstract_inverted_index.(Qiagen). | 151 |
| abstract_inverted_index.Ingenuity | 148 |
| abstract_inverted_index.analysis. | 135 |
| abstract_inverted_index.childhood | 12 |
| abstract_inverted_index.controls, | 261 |
| abstract_inverted_index.controls. | 173 |
| abstract_inverted_index.decreased | 183 |
| abstract_inverted_index.determine | 57 |
| abstract_inverted_index.explored. | 52 |
| abstract_inverted_index.expressed | 20, 195, 211 |
| abstract_inverted_index.increased | 252 |
| abstract_inverted_index.inhibitor | 179 |
| abstract_inverted_index.molecular | 229 |
| abstract_inverted_index.oncogenic | 263 |
| abstract_inverted_index.performed | 78, 97, 141 |
| abstract_inverted_index.potential | 63 |
| abstract_inverted_index.resulting | 143 |
| abstract_inverted_index.signaling | 240, 275 |
| abstract_inverted_index.submitted | 122 |
| abstract_inverted_index.treatment | 200 |
| abstract_inverted_index.warranted | 278 |
| abstract_inverted_index.BACKGROUND | 1 |
| abstract_inverted_index.Functional | 136, 206 |
| abstract_inverted_index.Sequencing | 108 |
| abstract_inverted_index.Therefore, | 53 |
| abstract_inverted_index.astrocytes | 88 |
| abstract_inverted_index.expressing | 164, 234 |
| abstract_inverted_index.expression | 61, 145, 155, 254 |
| abstract_inverted_index.functional | 124 |
| abstract_inverted_index.identified | 198 |
| abstract_inverted_index.implicated | 213, 242 |
| abstract_inverted_index.inhibition | 175 |
| abstract_inverted_index.inhibitor, | 119 |
| abstract_inverted_index.microRNAs, | 32 |
| abstract_inverted_index.migration, | 187 |
| abstract_inverted_index.migration. | 269 |
| abstract_inverted_index.oncogenes. | 40 |
| abstract_inverted_index.processes, | 222 |
| abstract_inverted_index.sequencing | 100 |
| abstract_inverted_index.suppresses | 27, 36 |
| abstract_inverted_index.&lt;-2, | 204 |
| abstract_inverted_index.CONCLUSIONS | 248 |
| abstract_inverted_index.LIN28B-let7 | 274 |
| abstract_inverted_index.single-read | 99 |
| abstract_inverted_index.therapeutic | 288 |
| abstract_inverted_index.(FC&gt;2 | 202 |
| abstract_inverted_index.Differential | 153 |
| abstract_inverted_index.Neurological | 216 |
| abstract_inverted_index.demonstrated | 157 |
| abstract_inverted_index.demonstrates | 251 |
| abstract_inverted_index.inactivation | 237 |
| abstract_inverted_index.subsequently | 140 |
| abstract_inverted_index.investigation | 271 |
| abstract_inverted_index.proliferation | 185, 267 |
| abstract_inverted_index.differentially | 194, 210 |
| abstract_inverted_index.p&lt;0.05). | 205 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 5 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7400000095367432 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.17623368 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |