DIPG-86. INVESTIGATING THE TUMOR ENVIRONMENT AND SIGNALING DEPENDENCIES DRIVING DIFFUSE MIDLINE GLIOMA TUMOR INITIATION, PROGRESSION, AND RESISTANCE: A COMPREHENSIVE APPROACH LEVERAGING BULK MULTIOMICS DECONVOLUTION AND SINGLE-CELL OMICS VALIDATION Article Swipe
Palak Patel
,
Scott Ryall
,
Bharti Kukreja
,
Andrei Turinski
,
Robert Siddaway
,
Michael Brudno
,
Arun Ramani
,
Sanja Pajovic
,
Brian T. Kalish
,
Cynthia Hawkins
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1093/neuonc/noae064.139
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1093/neuonc/noae064.139
BACKGROUND Diffuse Midline Glioma (DMG) is a incurable tumor affecting children. Recent genomic investigations have identified a recurrent H3K27M mutation which induces global alterations in histone methylation patterns and DNA methylation. These epigenetic modifications hint at pivotal roles in DMG pathogenesis, yet effective therapeutic strategies remain elusive, with median survival rates stagnant at approximately one year. This shortfall stems from two main factors: 1) Inadequate multiomics studies hindering our understanding of DMG evolution and tumor progression, and 2) Limited comprehension of the tumor microenvironment in DMG. METHODS To elucidate DMG’s clonal evolution, we adopted a comprehensive multi-region sampling approach, acquiring 33 specimens from seven patients. Whole-exome and transcriptome sequencing, alongside DNA methylation profiling, were performed. Additionally, we generated one of the most extensive single-cell multiomics datasets (>300,000 cells from 21 additional samples), with a focus on pre- and post-treatment, and dissemination effects in DMG. RESULTS Our analysis delineated a tumor-promoting microenvironment characterized by hypoxia and pro-inflammatory conditions, nurturing genomic alterations and specialized biological processes such as proliferation and epithelial-mesenchymal transition. Notably, a majority of immune cells exhibited M1-like polarization, bolstering pro-inflammatory programs within the tumor milieu. Subclones within the DMG cohort demonstrated dissemination potential, often exhibiting up-regulation of NOTCH, P53, and WNT beta-catenin signaling pathways. These findings suggest that DMG clones harboring dissemination capabilities outside the pons acquire additional phenotypic features, possibly mediated by epigenetic or transcriptional alterations, contributing to enhanced migratory and aggressive behaviors. CONCLUSIONS Our study unveils the parallel evolution of DMG at genetic, epigenetic, and transcriptional levels, unveiling novel subclonal phenotypes governing tumor behavior. Crucially, we identify critical environmental shifts such as hypoxia and inflammatory changes, coupled with specialized signaling programs, driving dissemination and resistance phenotypes. These insights may pave the way for generating accurate genetically mouse models and targeted therapeutic interventions to combat this challenging malignancy.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/neuonc/noae064.139
- https://academic.oup.com/neuro-oncology/article-pdf/26/Supplement_4/0/58252050/noae064.139.pdf
- OA Status
- hybrid
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4399787827
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4399787827Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1093/neuonc/noae064.139Digital Object Identifier
- Title
-
DIPG-86. INVESTIGATING THE TUMOR ENVIRONMENT AND SIGNALING DEPENDENCIES DRIVING DIFFUSE MIDLINE GLIOMA TUMOR INITIATION, PROGRESSION, AND RESISTANCE: A COMPREHENSIVE APPROACH LEVERAGING BULK MULTIOMICS DECONVOLUTION AND SINGLE-CELL OMICS VALIDATIONWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-06-18Full publication date if available
- Authors
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Palak Patel, Scott Ryall, Bharti Kukreja, Andrei Turinski, Robert Siddaway, Michael Brudno, Arun Ramani, Sanja Pajovic, Brian T. Kalish, Cynthia HawkinsList of authors in order
- Landing page
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https://doi.org/10.1093/neuonc/noae064.139Publisher landing page
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https://academic.oup.com/neuro-oncology/article-pdf/26/Supplement_4/0/58252050/noae064.139.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
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https://academic.oup.com/neuro-oncology/article-pdf/26/Supplement_4/0/58252050/noae064.139.pdfDirect OA link when available
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Deconvolution, Omics, Glioma, Cell, Computational biology, Cancer research, Medicine, Biology, Computer science, Bioinformatics, Genetics, AlgorithmTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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