Direct and pleiotropic effects of antimicrobial peptide transgene integration on reproductive, growth regulating, and non-coding loci in channel catfish (Ictalurus punctatus) Article Swipe
Jinhai Wang
,
Indira Medina Torres
,
Mei Shang
,
Jacob Al-Armanazi
,
Hamza Dilawar
,
Darshika Hettiarachchi
,
Abel Paladines-Parrales
,
Barrett Chambers
,
Kate Pottle
,
Misha Soman
,
Allison L. Wise
,
Rhoda Mae C. Simora
,
Timothy J. Bruce
,
Baofeng Su
,
Rex A. Dunham
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.agrcom.2024.100044
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.agrcom.2024.100044
Antimicrobial peptides (AMPs) show promise in enhancing resistance against pathogens. Previously, we integrated two AMP genes, cathelicidin (Cath) from alligator (Alligator mississippiensis or Alligator sinensis) and cecropin (Cec) from moth (Hyalophora cecropia), into the channel catfish (Ictalurus punctatus) genome. This study examines the efficacy of exogenous AMP gene integration in improving bacterial resistance in transgenic channel catfish and assesses the direct and pleiotropic effects of gene replacement/knockout on survival and growth based on insertion site. Transgenic Cath- and Cec-expressing fish exhibited similar or higher survival rates (P > 0.05) compared to controls during the initial culture. Integration of the Cec transgene doubled the survival rate when challenged with Edwardsiella ictaluri, with knock-in (KI) of Cath further increasing bacterial resistance. Coupling Cec KI with mstn knockout (KO) increased survival 3-fold after E. ictaluri infection and growth by 50% at 4 months post-fertilization (mpf). However, random integration of Cec had a minimal effect on disease resistance and did not enhance growth. Random integration of Cath increased survival 2.5-fold and 4-fold against E. ictaluri and Flavobacterium covae, respectively, without affecting growth. Cath KI at the lh locus increased survival 4-fold when challenged with F. covae and reduced growth by 10% (P > 0.05) at 24 mpf, whereas Cath KI coupled with mc4r KO resulted in a 2.5-fold increase in survival following F. covae infection compared with controls, and increased growth by 80% at 3 mpf. Simultaneous KI of Cath and Cec, along with KO of mc4r and mstn, increased survival 4-fold against E. ictaluri, while increasing growth by 50% at 3 mpf. Dual insertion of AMP genes yielded the greatest resistance to disease. These direct and pleiotropic effects may increase comprehension and societal acceptance of genetic engineering in aquaculture.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.agrcom.2024.100044
- OA Status
- diamond
- Cited By
- 13
- References
- 40
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4399294709
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4399294709Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.agrcom.2024.100044Digital Object Identifier
- Title
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Direct and pleiotropic effects of antimicrobial peptide transgene integration on reproductive, growth regulating, and non-coding loci in channel catfish (Ictalurus punctatus)Work title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-06-01Full publication date if available
- Authors
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Jinhai Wang, Indira Medina Torres, Mei Shang, Jacob Al-Armanazi, Hamza Dilawar, Darshika Hettiarachchi, Abel Paladines-Parrales, Barrett Chambers, Kate Pottle, Misha Soman, Allison L. Wise, Rhoda Mae C. Simora, Timothy J. Bruce, Baofeng Su, Rex A. DunhamList of authors in order
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https://doi.org/10.1016/j.agrcom.2024.100044Publisher landing page
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diamondOpen access status per OpenAlex
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https://doi.org/10.1016/j.agrcom.2024.100044Direct OA link when available
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Ictalurus, Catfish, Biology, Transgene, Genetics, Channel (broadcasting), Gene, Fishery, Telecommunications, Engineering, FishTop concepts (fields/topics) attached by OpenAlex
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13Total citation count in OpenAlex
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2025: 12, 2024: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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