Direct-Contact Cytotoxicity Evaluation of CoCrFeNi-Based Multi-Principal Element Alloys Article Swipe
Ryan Newell
,
Zi Wang
,
I. Ruiz Arias
,
Abhishek Mehta
,
Yongho Sohn
,
Stephen J. Florczyk
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.3390/jfb9040059
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.3390/jfb9040059
Transition metal multi-principal element alloys (MPEAs) are novel alloys that may offer enhanced surface and mechanical properties compared with commercial metallic alloys. However, their biocompatibility has not been investigated. In this study, three CoCrFeNi-based MPEAs were fabricated, and the in vitro cytotoxicity was evaluated in direct contact with fibroblasts for 168 h. The cell viability and cell number were assessed at 24, 96, and 168 h using LIVE/DEAD assay and alamarBlue assay, respectively. All MPEA sample wells had a high percentage of viable cells at each time point. The two quaternary MPEAs demonstrated a similar cell response to stainless steel control with the alamarBlue assay, while the quinary MPEA with Mn had a lower cell number after 168 h. Fibroblasts cultured with the MPEA samples demonstrated a consistent elongated morphology, while those cultured with the Ni control samples demonstrated changes in cell morphology after 24 h. No significant surface corrosion was observed on the MPEAs or stainless steel samples following the cell culture, while the Ni control samples had extensive corrosion. The cell growth and viability results demonstrate the cytocompatibility of the MPEAs. The biocompatibility of MPEAs should be investigated further to determine if MPEAs may be utilized in orthopedic implants and other biomedical applications.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/jfb9040059
- https://www.mdpi.com/2079-4983/9/4/59/pdf?version=1539942202
- OA Status
- gold
- Cited By
- 17
- References
- 41
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2896727161
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2896727161Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/jfb9040059Digital Object Identifier
- Title
-
Direct-Contact Cytotoxicity Evaluation of CoCrFeNi-Based Multi-Principal Element AlloysWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-10-19Full publication date if available
- Authors
-
Ryan Newell, Zi Wang, I. Ruiz Arias, Abhishek Mehta, Yongho Sohn, Stephen J. FlorczykList of authors in order
- Landing page
-
https://doi.org/10.3390/jfb9040059Publisher landing page
- PDF URL
-
https://www.mdpi.com/2079-4983/9/4/59/pdf?version=1539942202Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/2079-4983/9/4/59/pdf?version=1539942202Direct OA link when available
- Concepts
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Biocompatibility, Materials science, Viability assay, Cytotoxicity, Corrosion, Metal, Cell, Metallurgy, Biomedical engineering, In vitro, Biology, Medicine, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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17Total citation count in OpenAlex
- Citations by year (recent)
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2025: 5, 2024: 3, 2023: 2, 2022: 3, 2021: 1Per-year citation counts (last 5 years)
- References (count)
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41Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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